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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Clinical trial launched to investigate safety and efficacy of antiviral drug for COVID-19

Physician-scientists at four University of California Health medical centers -- UC San Diego Health, UC San Francisco, UC Irvine Health and UC Davis Health -- have begun recruiting participants for a Phase II clinical trial to investigate the safety and efficacy of treating adult patients with COVID-19 with remdesivir, an antiviral drug that has shown activity in animal models and human clinical trials of SARS-CoV, MERS-CoV, Ebola, Marburg and other viruses.

24 Mar 2020

Researchers rejuvenate aged human cells with stem cell technology

Scientists have used stem cell technology to force old human cells to rejuvenate, reversing the impact that aging has on cells.

24 Mar 2020

Crumpled graphene can be used to make ultra-sensitive cancer DNA detector

Crumpled graphene can enhance graphene-based biosensors, increasing sensitivity to DNA for accurate detection of cancer.

24 Mar 2020

Old human cells regain youthful strength after rejuvenating protein treatment, study finds

Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

24 Mar 2020

Crumpled grapheme can be more sensitive in detecting DNA cancer markers

Graphene-based biosensors could usher in an era of liquid biopsy, detecting DNA cancer markers circulating in a patient's blood or serum. But current designs need a lot of DNA.

24 Mar 2020

Huge WHO trial of COVID-19 therapies begins

As the world reels from the devastating impact and the looming threat of the novel coronavirus COVID-19, researchers around the globe are racing to find a cure that will reduce symptom severity and reverse the course of the disease, freeing up more hospital space and making it possible to treat more of the severely affected cases.

24 Mar 2020

The COVID-19 vaccine pipeline

Major nations are in a race to make an effective vaccine that could help treat the novel coronavirus infection COVID-19. As hundreds of thousands are infected across the world and over sixteen thousand killed, the pandemic shows no signs of relenting.

23 Mar 2020

3D chromatin landscapes in T cell acute lymphoblastic leukemia important beyond DNA code changes

Children with aggressive blood cancers have differences -- not just in the DNA code of their blood cells -- but also in the heavily twisted protein superstructure that controls access to genes.

23 Mar 2020

Scientists discover new genetic editing powers in squid

Revealing yet another super-power in the skillful squid, scientists have discovered that squid massively edit their own genetic instructions not only within the nucleus of their neurons, but also within the axon -- the long, slender neural projections that transmit electrical impulses to other neurons.

23 Mar 2020

Fatty acid-binding protein 4 plays an important role in kidney stone formation

Kidney stone disease has a high prevalence worldwide, ranging up to 13% in North America, 9% in Europe, and 5% in Asia. They are painful for patients, often lead to surgery, and impart a significant economic impact.

23 Mar 2020

Changes in 3D genetic structure equally important as DNA code mutations in childhood leukemia

A study found that children with aggressive blood cancers have different superstructures of the proteins that control gene access.

23 Mar 2020

Study sheds light on myelin's role in 'chemobrain' and multiple sclerosis

Scientists have discovered that myelin is not as metabolically inert as has previously been thought.

23 Mar 2020

Researcher working to measure gene expression in blood of patients treated for opioid use disorder

MingKuan Lin, Research Assistant Professor, INOVA Neuroscience, School of Systems Biology, is working to measure gene expression levels in blood from patients undergoing treatment with buprenorphine for opioid use disorder.

22 Mar 2020

DFG underlines the need for long-term, knowledge-driven basic research

In view of the coronavirus pandemic, the Deutsche Forschungsgemeinschaft has underlined the need for long-term, knowledge-driven basic research.

21 Mar 2020

New UCI-led study reveals how skin cells prepare to heal wounds

Scientists have revealed how skin cells prepare to heal, potentially leading to better understanding of healing within diabetes.

20 Mar 2020

Study reveals major changes that occur in mammalian skin cells during wound healing

A team of University of California, Irvine researchers have published the first comprehensive overview of the major changes that occur in mammalian skin cells as they prepare to heal wounds.

19 Mar 2020

Was the novel coronavirus really sneaky in its spread to the U.S.? Experts say no

Unveiling a series of policies meant to mitigate the threat of COVID-19, President Donald Trump also sought to respond to criticism that his administration has been slow to deal with what is now a worldwide pandemic.

19 Mar 2020

Targeting PI3Kβ alone and with combination therapy in PTEN-deficient tumors

The cover for issue 11 of Oncotarget features Figure 6, "Effects of AZD8186 in combination with anti-PD1 on syngeneic models," by Owusu-Brackett, et al.

18 Mar 2020

Researchers study how changing seasons will affect coronavirus spread

One of the biggest unknowns about the coronavirus is how changing seasons will affect its spread. Physicists from the University of Utah have received the university's first COVID-19-related grant to tackle the question.

18 Mar 2020

Bacterial extracellular vesicles could combat antibiotic resistance

Children's National Hospital researchers for the first time have isolated bacterial extracellular vesicles from the blood of healthy donors, a critical step to better understanding the way gut bacteria communicate with the rest of the body via the bloodstream.

18 Mar 2020