Kidney News and Research

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NYU Langone Health begins first clinical trial of gene-edited pig kidney transplants

The first surgery in a clinical trial testing the safety and efficacy of gene-edited pig kidney transplants in patients with end-stage renal disease was recently performed at NYU Langone Health.

5 Nov 2025

Rituximab shows remarkable success in adults with relapsing nephrotic syndrome

One monoclonal antibody, rituximab, can work wonders for the treatment of children with frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome.

5 Nov 2025

GLP-1 drugs calm inflammation beyond diabetes and weight loss

This Journal of Clinical Investigation review describes how glucagon-like peptide-1 (GLP-1)–based medicines reduce systemic and tissue inflammation through both weight-dependent and weight-independent mechanisms. It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

4 Nov 2025

Three health tech innovators push boundaries to build a brighter future of cardiovascular care

As digital health technologies gain momentum, research is finding that more people are open to artificial intelligence (AI) supported health interventions when those are backed by clinical expertise and rooted in evidence-based guidelines.

4 Nov 2025

AI in Healthcare: How generative tools are transforming clinical practice

Discover how generative AI is reshaping clinical care with real-world examples, challenges, and expert advice for AI adoption in healthcare

3 Nov 2025

Combined analysis of three blood tests enhances heart attack risk prediction

A combined analysis of blood tests to measure three biomarkers linked to higher risk of cardiovascular disease-lipoprotein a (Lp(a)), remnant cholesterol and high-sensitivity C-reactive protein (hsCRP)-may help identify high-risk individuals earlier and guide more personalized prevention strategies, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2025.

3 Nov 2025

Healthy lifestyle habits plus GLP-1 RA drugs can improve heart health of people with Type 2 diabetes

People with Type 2 diabetes who combined healthy lifestyle habits with GLP-1 receptor agonist (GLP-1 RA) medications had a greater reduction in risk of major adverse cardiovascular events, including heart attack, stroke or cardiovascular disease death, compared to people only taking the medication, according to a preliminary study to be presented at the American Heart Association's Scientific Sessions 2025.

3 Nov 2025

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

Researchers at the University Hospital Bonn (UKB) and the University of Bonn have discovered how a small, naturally occurring RNA molecule in the kidney activates a mutated immune receptor, triggering a chain reaction.

31 Oct 2025

Pioneering technology enables scalable production of human kidney organoids

A research team led by the Institute for Bioengineering of Catalonia (IBEC) and collaborating with the Biomedical Research Institute of A Coruña (INIBIC), as well as other international research groups, has developed pioneering technology that enables human kidney organoids to be produced in a scalable manner.

31 Oct 2025

Better treatments buoy multiple-myeloma patients, bound by research cuts and racial disparities

For more than a year, Diane Hunter, now 72, had been experiencing vague symptoms — pain in her spine and hips, nausea, exhaustion, thirst, and frequent urination.

31 Oct 2025

How early diabetes management influences long-term outcomes

Could slightly elevated blood sugar levels lead to serious health problems in the future? A single patient's question sparked nearly a decade of research leading to the development of a landmark model that could shape how clinicians and researchers understand and manage diabetes across the US.

30 Oct 2025

TROP2 identified as a promising therapeutic target for renal medullary carcinoma

Researchers at The University of Texas MD Anderson Cancer Center, in collaboration with BostonGene, conducted the largest and most comprehensive molecular analysis of renal medullary carcinoma (RMC), a rare and aggressive form of kidney cancer, leading to the identification of TROP2 as a promising therapeutic target.

30 Oct 2025

Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

Stem cells show promise in preventing post-heart attack heart failure

Patients with weak heart function who receive stem cell therapy shortly after a heart attack are at lower risk of developing heart failure and related hospital stays compared with standard care, finds a clinical trial published by The BMJ today.

30 Oct 2025

WHO reviews highlight limited long-term data on GLP-1 drug safety

Three new Cochrane reviews find evidence that GLP-1 drugs result in clinically meaningful weight loss, but industry-funded studies raise questions. The reviews were commissioned by the World Health Organization (WHO) to inform upcoming guidelines on the use of these drugs to treat obesity.

30 Oct 2025

Diabetes remission possible with GLP-1 drugs, Italian study confirms

In a large real-world Italian cohort, GLP-1 receptor agonist therapy led to measurable rates of type 2 diabetes remission, depending on how remission was defined. The most pragmatic definition (Remission 3) was linked to improved glycemia, weight, and a lower risk of microvascular and cardiovascular events.

29 Oct 2025

Scripps Research professor wins $3.2 million grant to unravel the mysteries of type 1 diabetes

Luc Teyton, professor in the Department of Immunology and Microbiology at Scripps Research, has received a five-year, $3.2 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to help answer how type 1 diabetes manifests and develop potential therapeutics to reverse or prevent the disease.

29 Oct 2025

Kidney News and Research

NYU Langone Health begins first clinical trial of gene-edited pig kidney transplants

Rituximab shows remarkable success in adults with relapsing nephrotic syndrome

GLP-1 drugs calm inflammation beyond diabetes and weight loss

Three health tech innovators push boundaries to build a brighter future of cardiovascular care

AI in Healthcare: How generative tools are transforming clinical practice

Combined analysis of three blood tests enhances heart attack risk prediction

Healthy lifestyle habits plus GLP-1 RA drugs can improve heart health of people with Type 2 diabetes

Mutated RIG-I receptor causes kidney inflammation through Y-RNA activation

Pioneering technology enables scalable production of human kidney organoids

Better treatments buoy multiple-myeloma patients, bound by research cuts and racial disparities

How early diabetes management influences long-term outcomes

TROP2 identified as a promising therapeutic target for renal medullary carcinoma

Advances in diagnosis and management of systemic light chain amyloidosis

Stem cells show promise in preventing post-heart attack heart failure

WHO reviews highlight limited long-term data on GLP-1 drug safety

Diabetes remission possible with GLP-1 drugs, Italian study confirms

Scripps Research professor wins $3.2 million grant to unravel the mysteries of type 1 diabetes

Experimental compound reduces cell death, inflammation, and organ damage in diabetes

Research shows the potential of structural nanomedicine in cancer treatment

Innovative approach to enhancing laser lithotripsy for kidney stones

Free guide - Everything about renal proximal tubule cells eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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