Preclinical News and Research

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Potential breakthrough in treating acute kidney injury with ceramide-targeting drugs

Serious damage to short-term kidney function-known as acute kidney injury, or AKI-can be fatal and also increase the risk of irreversible chronic kidney disease. It can be triggered by stressors ranging from sepsis to heart surgery, and it affects more than half of ICU patients.

12 Nov 2025

Breakthrough in bone regeneration using nanoparticle-stem cell hybrid

A research team in South Korea has successfully developed a novel technology that combines nanoparticles with stem cells to significantly improve 3D bone tissue regeneration.

12 Nov 2025

Common antibiotic can improve survival and neurological outcomes in CNS-TB

Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have demonstrated that doxycycline, a commonly available and inexpensive antibiotic, can improve survival rates and neurological outcomes in Central Nervous System Tuberculosis (CNS-TB) in a preclinical non-human study.

12 Nov 2025

Plant-based oat protein hybrid doubles iron absorption in women

Research on oat protein nanofibril-iron hybrids highlights their potential to significantly improve iron absorption, tackling global nutritional deficiencies.

12 Nov 2025

What makes truffles more than a delicacy? They’re packed with bioactive compounds

Italian researchers reviewed the chemical composition and biological potential of truffles, identifying them as rich sources of antioxidants, polysaccharides, sterols, and vitamins. The review highlights their promise as functional foods and natural therapeutics, while emphasizing the need for sustainable cultivation and clinical validation.

11 Nov 2025

New discovery reveals crucial link between cholesterol and breast cancer progression

Cancer Center at Illinois (CCIL) Program Leader Erik Nelson's lab made an important discovery about the relationship between cholesterol and breast cancer progression with crucial implications for breast cancer therapeutics.

11 Nov 2025

Long non-coding RNA MALAT1 linked to progression and spread of triple-negative breast cancer

When researchers look for potential cancer therapy targets, they typically go after protein-coding genes that participate in disease progression. Disrupt them and negate whatever role they play in cancer's development or spread.

11 Nov 2025

Preclinical study reveals dampened neuronal activity in alcohol-exposed mice

A psychedelic found in mushrooms is emerging as a potential treatment for alcohol use disorders. This possibility is due to a compound the body converts the psychedelic into called psilocin, but psilocin's mechanisms remain unclear.

11 Nov 2025

Study advances the possibility of age-based pancreatic cancer treatment

While some risk factors for cancer can be mitigated through lifestyle choices such as diet or exercise, aging is not one of them. In the case of pancreatic cancer, it also can limit treatment options if a patient is too frail to be safely treated with surgery or other alternatives.

10 Nov 2025

Groundbreaking vaccination approach could transform respiratory disease prevention

A research team from Trinity College Dublin has unveiled a groundbreaking new approach to vaccination that could redefine how we protect against respiratory infections.

10 Nov 2025

New diagnostic approach identifies dementia stages based on neurovascular and metabolic changes

Researchers from the Indiana University School of Medicine have developed a highly sensitive diagnostic that predicts a person's stage of dementia based on neurovascular and metabolic changes.

10 Nov 2025

Genetic and cellular mechanisms underlying steatotic liver disease

Steatotic liver disease (SLD), mainly encompassing metabolic dysfunction-associated steatotic liver disease (MASLD), alcohol-related liver disease (ALD), and metabolic dysfunction and ALD (MetALD), has emerged as the dominant cause of chronic liver disease worldwide, displacing viral hepatitis as the primary aetiology.

10 Nov 2025

Preclinical evidence supports sotagliflozin's superior efficacy in attenuating salt-induced kidney damage

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed to treat type 2 diabetes, have significant heart- and kidney- protective effects. In the kidney, SGLT2 reabsorbs approximately 97% offiltered glucose in the S1 and S2 segments of the proximal tubule, while SGLT1reabsorbs the remainder in the S3 segment.

8 Nov 2025

Machine learning advances human-centric drug toxicity prediction

In the UK, there was a case where TGN1412, an immunotherapy under development, triggered a cytokine storm within hours of administration to humans, leading to multiple organ failure.

7 Nov 2025

BIOVECTRA and Revolution Biomanufacturing partner to deliver integrated mRNA Design and GMP production services

BIOVECTRA, a part of Agilent Technologies Inc., and Revolution Biomanufacturing Inc. today announced a collaboration that grants BIOVECTRA access to Revolution Biomanufacturing's proprietary platforms for optimizing untranslated regions (UTRs) and codon usage to enhance mRNA stability and translational efficiency.

6 Nov 2025

Engineered biomaterial promotes formation of cancer-fighting immune cell clusters

Researchers at Moffitt Cancer Center have developed a novel biomaterial-based system that induces the formation of tertiary lymphoid-like structures, or TLSs.

6 Nov 2025

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

Long-term, low doses of THC mitigate many harmful side effects and inflammation caused by HIV and antiretroviral therapy (ART), according to new research from Texas Biomedical Research Institute.

6 Nov 2025

5,000 steps a day may slow Alzheimer’s-related brain changes

Regular walking is linked to slower cognitive decline in older adults, emphasizing its role in delaying Alzheimer’s disease and enhancing memory retention.

6 Nov 2025

Combination therapy offers hope for ending lifelong chronic lymphocytic leukemia treatment

Ianalumab targets the B-cell activating factor receptor (BAFR) and ibrutinib belongs to a class of therapeutics called Bruton's tyrosine kinase inhibitors (BTKi).

6 Nov 2025

New combination treatment overcomes resistance in ER positive breast cancer

In preclinical studies, researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have tested a new combination therapy for hormone-resistant, estrogen receptor-positive (ER+) breast cancer and were able to shrink tumors, reduce the number of cancer stem cells and reprogram the immune environment to be less supportive of cancer growth.

6 Nov 2025

Preclinical News and Research

Potential breakthrough in treating acute kidney injury with ceramide-targeting drugs

Breakthrough in bone regeneration using nanoparticle-stem cell hybrid

Common antibiotic can improve survival and neurological outcomes in CNS-TB

Plant-based oat protein hybrid doubles iron absorption in women

What makes truffles more than a delicacy? They’re packed with bioactive compounds

New discovery reveals crucial link between cholesterol and breast cancer progression

Long non-coding RNA MALAT1 linked to progression and spread of triple-negative breast cancer

Preclinical study reveals dampened neuronal activity in alcohol-exposed mice

Study advances the possibility of age-based pancreatic cancer treatment

Groundbreaking vaccination approach could transform respiratory disease prevention

New diagnostic approach identifies dementia stages based on neurovascular and metabolic changes

Genetic and cellular mechanisms underlying steatotic liver disease

Preclinical evidence supports sotagliflozin's superior efficacy in attenuating salt-induced kidney damage

Machine learning advances human-centric drug toxicity prediction

BIOVECTRA and Revolution Biomanufacturing partner to deliver integrated mRNA Design and GMP production services

Engineered biomaterial promotes formation of cancer-fighting immune cell clusters

Low-dose THC mitigates harmful side effects and inflammation caused by HIV treatment

5,000 steps a day may slow Alzheimer’s-related brain changes

Combination therapy offers hope for ending lifelong chronic lymphocytic leukemia treatment

New combination treatment overcomes resistance in ER positive breast cancer

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