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New study discovers key brain circuit implicated in social behavior

A new study by researchers at Roche in Basel, Switzerland has identified a key brain region of the neural circuit that controls social behavior. Increasing the activity of this region, called the habenula, led to social problems in rodents, whereas decreasing activity of the region prevented social problems.

11 Jan 2018

Researchers create ‘protocells’ for delivering drugs to deepest tumor regions

Despite herculean efforts, cancer remains a formidable disease, with each malignant subtype responding differently to therapeutics.

11 Jan 2018

Company-sponsored CRISPR clinical studies to begin in 2018

This year could be a defining one for CRISPR, the gene editing technique, which has been hailed as an important breakthrough in laboratory research.

10 Jan 2018

Researchers awarded grant to repurpose FDA-approved drugs for treating Alzheimer's patients

Researchers from Case Western Reserve University School of Medicine and collaborators have received a five-year, $2.8 million grant from the National Institute on Aging to identify FDA-approved medications that could be repurposed to treat Alzheimer's disease.

9 Jan 2018

Regeneron forms consortium to accelerate largest widely-available human sequencing resource

By the end of 2019, Regeneron plans to sequence the exomes of all 500,000 people within the UK Biobank resource, all with associated health records, creating an unprecedented resource linking human genetic variations to human biology and disease.

9 Jan 2018

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.

8 Jan 2018

Researchers describe key cellular receptor involved in ovarian cancer metastasis

Researchers of the Molecular Signaling in Cancer group of the Oncobell program - proCURE Program have described a key cellular receptor in the processes of metastasis in ovarian cancer.

4 Jan 2018

Rutgers researcher receives $1 million grant for international prostate cancer study

A $1 million grant from Gateway for Cancer Research will help Rutgers Cancer Institute of New Jersey Urologic Oncology Chief Isaac Yi Kim, MD, PhD, MBA evaluate the impact of surgically removing the prostate in men with metastatic prostate cancer in the United States and Asia.

2 Jan 2018

Japanese researchers propose new diagnostic criteria and treatment guidelines for thyroid storm

With a mortality rate estimated at 10%, the life-threatening condition known as thyroid storm (TS) demands rapid diagnosis and treatment and can benefit from new evidence-based guidelines for TS developed by researchers in Japan.

2 Jan 2018

Experimental diabetes drugs can make cancer cells vulnerable to chemotherapy agents

Scientists at Dana-Farber Cancer Institute have shown that experimental diabetes drugs can make cancer cells more vulnerable to traditional chemotherapy agents, and they say such combinations should be explored to potentially improve outcomes for cancer patients.

2 Jan 2018

Novel drug shows promise in treating metastatic kidney cancer

Metastatic kidney cancer remains largely incurable. Despite a dozen treatments and several immunotherapies, survival rates beyond 5 years remain around 10 percent.

21 Dec 2017

Findings provide better understanding of thyroid hormones' role in mammalian seasonal changes

Researchers now have a better understanding of the role that thyroid hormones, the tissues that produce them, and the biochemical pathways on which they act have in driving seasonal reproduction in some mammals, and how this new information may help explain seasonal changes in metabolism and mood that affect humans.

21 Dec 2017

Smartphone app can detect worsening symptoms during cancer treatments

Cancer patients receiving chemotherapy can be remotely monitored using their smartphone sensors and an algorithm that detects worsening symptoms based on objective changes in patient behavior, according to a new study from the University of Pittsburgh and UPMC Hillman Cancer Center.

20 Dec 2017

Two studies show how cells adapt to stressors by reprogramming internal signaling networks

In a pair of publications, researchers have shown how cells adapt to stressors--like water loss--by reprogramming their internal signaling networks.

20 Dec 2017

Antidepressant may also alleviate multiple sclerosis symptoms

The antidepressant clomipramine may also alleviate symptoms of multiple sclerosis (MS), specifically in its progressive form, i.e. when it occurs without relapses or remissions.

20 Dec 2017

Scientists develop test to predict treatment outcomes in patients with childhood leukemia

UC San Francisco physician-scientists have developed a test that can predict how patients with juvenile myelomonocytic leukemia (JMML) will respond to treatment, and may also be able to identify patients who are likely to recover spontaneously with little to no treatment.

19 Dec 2017

FDA approves new gene therapy targeting rare form of inherited vision loss

The U.S. Food and Drug Administration today approved Luxturna (voretigene neparvovec-rzyl), a new gene therapy, to treat children and adult patients with an inherited form of vision loss that may result in blindness.

19 Dec 2017

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers at The Wistar Institute have found that combining PARP inhibitors, recently approved for the treatment of BRCA-mutant ovarian cancer, with another small molecule inhibitor was effective to treat ovarian cancers without BRCA1 and BRCA2 gene mutations.

19 Dec 2017

Researchers identify novel mechanism that protects from brain tumor

A group of researchers at the Spanish National Cancer Research Centre have identified a protein called RanBP6 as a new regulator of EGFR. In a paper published in Nature Communications they show how silencing of RanBP6 promoted glioma growth, by upregulating EGFR expression.

18 Dec 2017

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Understanding how cancer cells are able to metastasize -- migrate from the primary tumor to distant sites in the body -- and developing therapies to inhibit this process are the focus of many laboratories around the country.

18 Dec 2017

Therapeutics News and Research

New study discovers key brain circuit implicated in social behavior

Researchers create ‘protocells’ for delivering drugs to deepest tumor regions

Company-sponsored CRISPR clinical studies to begin in 2018

Researchers awarded grant to repurpose FDA-approved drugs for treating Alzheimer's patients

Regeneron forms consortium to accelerate largest widely-available human sequencing resource

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Researchers describe key cellular receptor involved in ovarian cancer metastasis

Rutgers researcher receives $1 million grant for international prostate cancer study

Japanese researchers propose new diagnostic criteria and treatment guidelines for thyroid storm

Experimental diabetes drugs can make cancer cells vulnerable to chemotherapy agents

Novel drug shows promise in treating metastatic kidney cancer

Findings provide better understanding of thyroid hormones' role in mammalian seasonal changes

Smartphone app can detect worsening symptoms during cancer treatments

Two studies show how cells adapt to stressors by reprogramming internal signaling networks

Antidepressant may also alleviate multiple sclerosis symptoms

Scientists develop test to predict treatment outcomes in patients with childhood leukemia

FDA approves new gene therapy targeting rare form of inherited vision loss

Study finds combination therapy as effective strategy to treat ovarian cancers

Researchers identify novel mechanism that protects from brain tumor

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Next-generation therapeutics eBook eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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