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Evidence suggests bypass surgery free of long-term brain effects

A broad retrospective review of the effects of coronary artery bypass grafting (CABG) on memory and other brain functions concludes that, while there may be transient short-term effects, the procedure itself probably does not cause late or permanent neurological effects.

25 Apr 2005

Pattern of gene expression predicts multiple drug resistance, treatment failure in pediatric leukemia

The discovery of a specific pattern of gene expression linked to multiple-drug resistance of leukemic cells is giving researchers crucial information into why standard therapies fail to cure some children with acute lymphoblastic leukemia (ALL). This finding, from investigators at St. Jude Children’s Research Hospital, could lead to development of drugs that would overcome that resistance.

24 Apr 2005

Increasing benefit seen in novel drug AMN107, that treats Gleevec resistance

An investigational drug is producing powerful responses in patients resistant to Gleevec, the targeted therapy that helps most people diagnosed with chronic myeloid leukemia (CML), an international research team headed by investigators at The University of Texas M. D. Anderson Cancer Center is reporting.

23 Apr 2005

Fatness, despite fitness, is linked with cardiovascular risk factors

Body fatness was associated with more cardiovascular disease risk factors even among healthy, aerobically fit men, according to a report today in an obesity-themed issue of Circulation: Journal of the American Heart Association.

23 Apr 2005

Obesity and insulin resistance fuels cardiovascular risk factors in teens

Obesity and insulin resistance are a menacing tag team that fuels cardiovascular risk factors in teens, according to a study reported in an obesity-themed issue of Circulation: Journal of the American Heart Association.

23 Apr 2005

Drinking wine or beer has same result: higher blood pressure

Whether the drink of choice is a frosty beer or a full-bodied red wine, the effect is the same – higher blood pressure, according to research reported in Hypertension: Journal of the American Heart Association.

23 Apr 2005

Enlarged waist + elevated triglycerides = heart, stroke risks for women

A tape measure and a simple blood test may be the best way to gauge cardiovascular risk for postmenopausal women, according to a report published today in an obesity-themed issue of Circulation: Journal of the American Heart Association.

23 Apr 2005

When flying this summer, beware of blood clots and leg ulcers

Although recent news coverage has linked long-distance air travel with the dangers of blood clots, few people have realized the increased risk for leg ulcers, as well.

23 Apr 2005

Scientists have, for the first time, induced a state of reversible metabolic hibernation in mice

Scientists at Fred Hutchinson Cancer Research Center have, for the first time, induced a state of reversible metabolic hibernation in mice. This achievement, the first demonstration of "hibernation on demand" in a mammal, ultimately could lead to new ways to treat cancer and prevent injury and death from insufficient blood supply to organs and tissues.

23 Apr 2005

Using light under your skin

You have a tiny wound on your hand that doesn’t heal, a bad burn on your chest – or an injured retina. Your doctor cannot tell how serious the injuries are below the surface. He needs tissue samples. That means using a scalpel, which again equals pain, perhaps even a risk. Soon there may be hope for an improved and totally harmless method to peer under the surface of the skin: light.

23 Apr 2005

Nanoparticles reveal tiny cancerous tumors

Specially designed nanoparticles can reveal tiny cancerous tumors that are invisible by ordinary means of detection, according to a study by researchers at Washington University School of Medicine in St. Louis.

22 Apr 2005

Exposure to air pollutants increases the risk of fatal myocardial infarction

Cardiovascular diseases are the most common cause of death in Sweden and other Western European countries. Known risk factors include age, gender, hereditariness, smoking, hypertension and high blood lipid levels.

22 Apr 2005

High levels of immunosuppressant may lead to tumor recurrence

A new study on the incidence of liver cancer after transplant found that high levels of the immunosuppressant cyclosporine favored tumor recurrence and identified blood levels of the drug that should not be exceeded. Lower levels of cyclosporine levels did not affect rejection rates.

22 Apr 2005

Mice put into "suspended animation" in U.S.

Researchers from the University of Washington and the Fred Hutchinson Cancer Research Centre in Seattle have placed mice in a state of near suspended animation, raising the possibility that in future hibernation could be induced in humans.

22 Apr 2005

Genetic variation linked to alcohol dependence

The same gene that accounts for part of a genetic risk for developing alcoholism in a U.S. population is found in a Russian population, according to a published study by a Yale School of Medicine researcher.

22 Apr 2005

Brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism

A new mouse study suggests that a brain system that controls the sleep/wake cycle might also play a role in regulating appetite and metabolism. Mice with a mutation in a gene called "Clock," which helps drive circadian rhythm, ate significantly more and gained more weight.

22 Apr 2005

Enzyme that helps trigger the development of leukemia

Scientists at the University of North Carolina at Chapel Hill have identified an enzyme that helps trigger the development of leukemia, a cancer of blood cells.

21 Apr 2005

Body's 24-hour internal clock linked to obesity and diabetes

Obesity and diabetes in both adults and children are rising at alarming rates and a wide range of culprits -- super-sized food portions, lack of exercise due to television, computers, suburban sprawl and loss of gym classes, high-fat and fast foods, sugar-laden drinks and psychological trauma -- have been blamed.

21 Apr 2005

Strongest evidence yet that infectious misformed proteins cause mad cow disease

Researchers at the University of Texas Medical Branch at Galveston (UTMB) have produced the strongest proof yet that the mysterious and devastating brain diseases known as "transmissible spongiform encephalopathies" (TSEs) are transmitted by an infectious agent composed only of a malformed protein, and not a virus.

21 Apr 2005

Anti-malarial drug combo could help address malaria crisis in Africa

Using a combination of two drugs—artemether and lumefantrine—is the most effective way to treat malaria in the areas of Africa where resistance to commonly used malaria drugs is high, concludes a randomised trial published in this week’s issue of The Lancet.

21 Apr 2005