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SARS-CoV-2 escape mutations identified against monoclonal antibodies and polyclonal immune sera

A recent study describes the experimental selection of SARS-CoV-2 mutants associated with resistance to antibodies, with important implications for vaccine development and therapeutic antibody use.

8 Feb 2021

Experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients

A clinical study led by Dr. Jordan Feld, a liver specialist at Toronto Centre for Liver Disease, University Health Network (UHN), showed an experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients – patients who do not need to be hospitalized.

8 Feb 2021

SARS-CoV-2 delays interferon signaling in host cells

A team of scientists from Sweden and India has recently conducted a study to evaluate type I interferon (IFN-I) responses in cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The findings reveal that SARS-CoV-2 infection is associated with a delayed and dysregulated IFN-I response and that pretreatment with IFN-I can reduce the risk of SARS-CoV-2 infection.

7 Feb 2021

Molecular surveillance of SARS-CoV-2 spike protein mutations using CovRadar

In a recent bioRxiv preprint research paper, scientists from Germany discuss how they made sequence information more easily accessible for epidemiologists and virologists.

7 Feb 2021

New SARS-Cov-2 mutations could arise during chronic infection, say scientists

SARS-CoV-2 mutations similar to those in the B1.1.7 UK variant could arise in cases of chronic infection, where treatment over an extended period can provide the virus multiple opportunities to evolve, say scientists.

7 Feb 2021

Subdominant SARS-CoV-2 epitopes key to understanding emerging variants

Researchers in the UK have conducted a study showing the importance of considering subdominant epitopes within severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) when investigating neutralizing antibodies that target the virus.

7 Feb 2021

Novel immunotherapy approach to revert the main hallmarks of cat allergy

Researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) brought forward the potential of high doses of a specific adjuvant molecule, namely CpG oligonucleotide, in successfully modulating the immune system's allergic response to the main cat allergen Fel d 1, thereby inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy.

5 Feb 2021

$FDA approves cell-based gene therapy to treat adults with relapsed or refractory large-B-cell lymphoma$

FDA approves cell-based gene therapy to treat adults with relapsed or refractory large-B-cell lymphoma

Today, the U.S. Food and Drug Administration approved Breyanzi (lisocabtagene maraleucel), a cell-based gene therapy to treat adult patients with certain types of large B-cell lymphoma who have not responded to, or who have relapsed after, at least two other types of systemic treatment.

5 Feb 2021

Researchers unlock mysteries of protein that plays key regulatory role in cancer therapies

Researchers from the University of Virginia, Lehigh University, and the Massachusetts Institute of Technology are pooling their respective labs' expertise to unlock the mysteries of a protein that plays a critical regulatory role in human health and disease. Knowing how the protein works could lead to improved therapies for cancers and other diseases.

5 Feb 2021

Alpaca nanobodies neutralize SARS-CoV-2 in vitro

A new preprint research paper posted to the bioRxiv server reports the development of highly effective neutralizing nanobodies targeting the viral receptor-binding domain (RBD), thus disrupting its engagement with the host cell angiotensin-converting enzyme 2 (ACE2) receptor.

4 Feb 2021

SARS-CoV-2 N501Y mutation adversely affects cellular immune response

Among these is the B.1.1.7 SARS-CoV-2 variant, with its characteristic N501Y mutation. A new preprint on the bioRxiv server reports the impact of this mutation on CD4 T cell responses, including antigen presentation on cells expressing Major Histocompatibility Complex (MHC) class II molecules.

4 Feb 2021

POSTECH researchers discover mechanism behind intestinal epithelial lymphocyte differentiation

The intestine harbors the largest number of immune cells in our body. Since the intestine is constantly exposed to various antigens like bacteria and food, appropriate induction of gut immune cells plays a pivotal role in gut homeostasis.

4 Feb 2021

South African SARS-CoV-2 variant neutralized by two Chinese vaccines in case study

A new study offers some reassuring findings, reporting the successful neutralization of the South African SARS-CoV-2 variant of concern (VOC) 501Y.V2 by two vaccines developed in China.

4 Feb 2021

Pfizer vaccine and Eli Lilly monoclonal antibodies successfully neutralize SARS-CoV-2 UK variant, finds study

A new study reports the underlying basis of increased transmissibility in the N501Y UK variant and provides reassuring data on the efficacy of the Pfizer vaccine and Eli Lilly monoclonal antibodies in neutralizing it.

4 Feb 2021

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

A new study server reports highly protective neutralizing monoclonal antibodies against the SARS-CoV-2.

4 Feb 2021

New study reviews effect of coffee on people's sleep and wake cycles

The Institute for Scientific Information on Coffee (ISIC) published a new report today, titled 'Coffee and sleep in everyday lives', authored by Professor Renata Riha, from the Department of Sleep Medicine at the University of Edinburgh.

4 Feb 2021

Sulforaphane prolongs lifespan and healthspan of C. elegans through insulin/IGF-1 signaling

Aging-US published "Sulforaphane promotes C. elegans longevity and healthspan via DAF- 16/DAF-2 insulin/IGF-1 signaling" which reported that the broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear.

4 Feb 2021

Predicting future mamalian hosts of SARS-CoV-2

Researchers at the Beijing Computational Science Research Center and Peking University analyzed sequences of the angiotensin-converting enzyme 2 (ACE2) proteins from 16 mammals and predicted the structures of ACE2- receptor-binding domain (RBD) complexes.

4 Feb 2021

Preclinical study uncovers how Zika virus passes from mother to fetus during pregnancy

A preclinical study by a University of South Florida Health Morsani College of Medicine research team has discovered a new mechanism for how Zika virus can pass from mothers to their children during pregnancy - a process known as vertical transmission.

3 Feb 2021

Phase 1 clinical trial of novel HIV vaccine approach shows promising results

A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today.

3 Feb 2021

Receptor News and Research

SARS-CoV-2 escape mutations identified against monoclonal antibodies and polyclonal immune sera

Experimental antiviral drug can significantly speed up recovery for COVID-19 outpatients

SARS-CoV-2 delays interferon signaling in host cells

Molecular surveillance of SARS-CoV-2 spike protein mutations using CovRadar

New SARS-Cov-2 mutations could arise during chronic infection, say scientists

Subdominant SARS-CoV-2 epitopes key to understanding emerging variants

Novel immunotherapy approach to revert the main hallmarks of cat allergy

FDA approves cell-based gene therapy to treat adults with relapsed or refractory large-B-cell lymphoma

Researchers unlock mysteries of protein that plays key regulatory role in cancer therapies

Alpaca nanobodies neutralize SARS-CoV-2 in vitro

SARS-CoV-2 N501Y mutation adversely affects cellular immune response

POSTECH researchers discover mechanism behind intestinal epithelial lymphocyte differentiation

South African SARS-CoV-2 variant neutralized by two Chinese vaccines in case study

Pfizer vaccine and Eli Lilly monoclonal antibodies successfully neutralize SARS-CoV-2 UK variant, finds study

Monoclonal antibodies against SARS-CoV-2 spike's N-terminal prove highly protective in vivo

New study reviews effect of coffee on people's sleep and wake cycles

Sulforaphane prolongs lifespan and healthspan of C. elegans through insulin/IGF-1 signaling

Predicting future mamalian hosts of SARS-CoV-2

Preclinical study uncovers how Zika virus passes from mother to fetus during pregnancy

Phase 1 clinical trial of novel HIV vaccine approach shows promising results

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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