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Gene therapy shows effect in heart patients

The first double-blind, placebo-controlled randomized trial of VEGF gene injections into the heart muscle of patients with coronary artery disease with the intention of spurring growth of new blood vessels showed significant effects on heart wall motion, although blood flow was not significantly better in treated patients, according to a new study in the April 5, 2005, issue of the Journal of the American College of Cardiology.

5 Apr 2005

Researchers have identified a new clinical syndrome

Researchers have identified a new clinical syndrome that produces serious and sometimes fatal symptoms in a variety of seemingly unrelated diseases. The syndrome, described in the April 6 issue of the Journal of the American Medical Association, is caused by hemolysis, the destruction of red blood cells.

5 Apr 2005

How heart is formed in the embryo helps explain congenital heart disease

Children's Hospital of Pittsburgh Cardiologist Bradley B. Keller, MD, and his research team are discovering details in the lab that explain how the heart is formed in the embryo. This knowledge improves the chances of doctors identifying fetuses who can benefit from intervention to treat congenital defects.

5 Apr 2005

Metabolic side effects of antipsychotics are known, but rarely monitored

Psychiatrists are doing a “modest” job of monitoring for weight gain, diabetes and other metabolic problems that may result from use of the newer antipsychotics for schizophrenia, researchers say.

5 Apr 2005

Dallas heart study researchers find no link between Lp(a), calcium

The latest findings from the historic Dallas Heart Study have ruled out one of the most prominent explanations of why elevated levels of a fat-carrying protein called "lipoprotein(a)" lead to increased risks for heart attacks among whites but not among African-Americans.

5 Apr 2005

Important trial in the fight against lung cancer

Two University of Kentucky researchers continue their work with a vaccine to prevent lung cancer recurrences in patients following primary treatment of the disease.

5 Apr 2005

Meningitis epidemics driven by the wind

A meningitis epidemic hits West Africa every year, affecting 25 000 to 200 000 people. It has long been known that the timing of this epidemic and its spatial distribution within the “Meningitis Belt”, situated between 10° and 15° North, are closely linked to climatic conditions. Involved in the AMMA programme, IRD and University of Paris-VII researcher produced the first quantified description of this relationship using statistical methods.

5 Apr 2005

Sildenafil prevents anti-cancer drug induced heart damage

Virginia Commonwealth University researchers have found that the popular impotence drug Viagra prevents damage to the heart from a potent chemotherapeutic agent frequently used in the treatment of breast cancer, leukemia and sarcomas.

5 Apr 2005

Method of gene therapy accurately corrects mutations in disease-causing genes

Harnessing the strength of a natural process that repairs damage to the human genome, a researcher from UT Southwestern Medical Center has helped establish a method of gene therapy that can accurately and permanently correct mutations in disease-causing genes.

5 Apr 2005

When treating malaria is a waste of money

Africa may fail to benefit from new and better drugs for malaria because of massive misdiagnosis of the disease by health workers and patients.

5 Apr 2005

DNA repair kit announced by scientists

A study by scientists at Sangamo BioSciences, Inc. has demonstrated the use of the Company's zinc finger DNA-binding protein (ZFP) technology to achieve highly efficient, permanent correction of a disease-causing gene in primary human cells.

5 Apr 2005

Canada spends more on stem cell research

Canadian Justice Minister Irwin Cotler gave Canadian stem cell research an extra boost with the announcement of $5.3 million in annual funding.

5 Apr 2005

International commitment to reduce maternal and child deaths by 2015 will not be met

An international commitment to reduce maternal and child deaths by 2015 will not be met at the current pace unless rapid and coordinated action is taken now, the World Health Organization (WHO) has warned.

5 Apr 2005

First evidence that preeclampsia can leave a persistent and potentially fatal imprint in the pulmonary circulation of the fetus

Children born of mothers who had preeclampsia during their pregnancy are more likely to have pulmonary hypertension than similar children born from normal pregnancies, according to a study conducted in Bolivia by Swiss and Bolivian researchers.

4 Apr 2005

Gene mutation protecting against malaria linked to prostate cancer incidence in African-American men

Research from the University of Cincinnati College of Medicine suggests that the 60 percent greater incidence of prostate cancer among African-American men is related to a gene mutation developed generations ago in West Africa as nature's way of providing protection from the malaria infection endemic in that part of the world.

4 Apr 2005

Zinc appears to help boys learn

Seventh graders given 20 mg zinc, five days per week, for 10 to 12 weeks showed improvement in mental performance, responding more quickly and accurately on memory tasks and with more sustained attention, than classmates who received no additional zinc.

4 Apr 2005

Natural killer cells could lead to new Hepatitis treatments

Researchers have discovered that natural killer T (NKT) cells, the immune system's sentinels, patrol the labyrinthine blood vessels of the liver for invaders or signs of tissue damage and demonstrate a dogged behavior not seen before in other T cells.

4 Apr 2005

Immune cells in the liver travel in the liver's blood vessels with surprising speed and agility

Scientists at New York University School of Medicine viewing the actual journey of immune cells in the liver have found that these cells travel in the liver's blood vessels with surprising speed and agility.

4 Apr 2005

Method of gene therapy that can accurately and permanently correct mutations in disease-causing genes

4 Apr 2005

Bionic eyes from Stanford

Stanford physicists and eye doctors have teamed up to design a "bionic eye," of sorts. On Feb. 22 in the Journal of Neural Engineering, Daniel Palanker, Alexander Vankov and Phil Huie from the Department of Ophthalmology and the Hansen Experimental Physics Laboratory and Stephen Baccus from the Department of Neurobiology published a design of an optoelectronic retinal prosthesis system that can stimulate the retina with resolution corresponding to a visual acuity of 20/80

4 Apr 2005