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New compounds identified as inhibitors of DNA topoisomerase 1

Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at the University of Seville in CABIMER) and with PharmaMAR, has identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA.

29 Apr 2025

Noninvasive decoder could help restore movement after spinal cord injury

When a person sustains an injury to the spinal cord, the normal communication between the brain and the spinal circuits below the injury are interrupted, resulting in paralysis.

29 Apr 2025

Intimate relationships may shield against cognitive decline during chemo

A satisfying intimate relationship may help diminish chemotherapy-related cognitive problems experienced by patients with breast cancer, a new study suggests.

29 Apr 2025

Researchers uncover how substance use accelerates brain aging

In a comprehensive Genomic Press Interview, researchers from UTHealth Houston have uncovered crucial evidence that substance use disorders (SUDs) accelerate biological aging in the brain through distinct molecular mechanisms.

29 Apr 2025

Researchers discover new biomarker to predict multiple sclerosis progression

Researchers at the University of Turku, Finland, have discovered a new biomarker that can predict the progression of multiple sclerosis (MS).

29 Apr 2025

Perceived stress linked to worsened symptoms in COPD patients

Increased perceived stress may cause worsened respiratory symptoms and decreased quality of life in people with chronic obstructive pulmonary disease (COPD), according to a new study.

29 Apr 2025

Phthalates linked to hundreds of thousands of global heart disease deaths

Daily exposure to certain chemicals used to make plastic household items could be linked to the more than 356,000 global deaths from heart disease that occurred in 2018 alone, a new analysis of population surveys shows.

29 Apr 2025

PET scans reveal early signs of Parkinson’s and Lewy body disorders

In a comprehensive Genomic Press perspective article published today, researchers from Fudan University and Shanghai University of Traditional Chinese Medicine have highlighted remarkable advances in the development of positron emission tomography (PET) tracers capable of visualizing α-synuclein aggregates in the brains of patients with Parkinson's disease and related disorders.

29 Apr 2025

Global analysis ties plastic ingredient to soaring heart disease deaths

Daily exposure to certain chemicals used to make plastic household items could be linked to more than 356,000 global deaths from heart disease in 2018 alone, a new analysis of population surveys shows.

29 Apr 2025

Largest study to date reveals high blood sugar accelerates heart damage in healthy youth

In the present study, 1,595 adolescents drawn from the University of Bristol's Children of the 90s cohort were followed up from age 17 until 24 years. To assess the prevalence of prediabetes, which refers to high fasting blood glucose levels, two alternative cutpoints were used, a stricter cutpoint of ≥5.6 mmol/L recommended by the American Diabetes Association, and ≥6.1 mmol/L , which is the present recommendation in many countries.

29 Apr 2025

Global Virus Network urges action to prevent H5N1 pandemic

Today, the Global Virus Network (GVN), representing eminent human and animal virologists from 80+ Centers of Excellence and Affiliates in 40+ countries, published a comprehensive analysis and call-to-action in The Lancet Regional Health-Americas on the North American avian influenza virus, or H5N1, outbreak. The GVN calls on world governments to address the threat of H5N1 avian influenza by enhancing surveillance, implementing biosecurity measures, and preparing for potential human-to-human transmission.

29 Apr 2025

Uncovering non-clinical risk factors through mendelian randomization

A new study identifying 56 non-clinical risk factors associated with sudden cardiac arrest (SCA), spanning lifestyle, physical measures, psychosocial factors, socioeconomic status, and the local environment, offers compelling evidence that improving these unfavorable profiles could prevent up to 63% of SCA cases.

29 Apr 2025

New program connects breast cancer patients to exercise and rehab services

A recent randomized controlled trial reveals the potential of a program designed to connect patients who have breast cancer to needed exercise and rehabilitation services starting at diagnosis and throughout care.

28 Apr 2025

New $224 million proton therapy center coming to Penn Presbyterian

Today, Penn Medicine celebrated the groundbreaking of the Roberts Proton Therapy Center at Penn Presbyterian Medical Center in University City, which is expected to open for patient care in late 2027.

28 Apr 2025

Anti-inflammatory drug can prevent and alleviate periodontal tissue damage

A recent study reveals that dimethyl fumarate (DMF), a compound already approved for other inflammatory diseases, can prevent and alleviate periodontal tissue damage.

28 Apr 2025

Immunotherapy replaces surgery for early-stage dMMR cancers in landmark study

Neoadjuvant PD-1 blockade with dostarlimab achieved high rates of organ preservation in patients with early-stage mismatch repair-deficient (dMMR) solid tumors across multiple types. Most patients avoided surgery with durable disease control, reshaping potential cancer treatment pathways.

28 Apr 2025

Trump administration retreats from 100% withholding on Social Security clawbacks

The Social Security Administration is backing off a plan it announced in March to withhold 100% of many beneficiaries' monthly payments to claw back money the government had allegedly overpaid them.

28 Apr 2025

Largest study identifies new genetic targets for osteoarthritis treatment

Researchers have uncovered multiple new genes and genetic pathways that could lead to repurposing hundreds of existing drugs for osteoarthritis, the most common form of arthritis.

28 Apr 2025

Health care providers working together as ACOs save Medicare billions over long term

Teams of health care providers called Accountable Care Organizations participating in the Medicare Shared Savings Program have saved Medicare between $4.1 billion and $8.1 billion from 2012 through 2019, according to a new study from Weill Cornell Medicine investigators.

28 Apr 2025

CommunityRx program reduces ER visits for food insecure children

In a new clinical study published in JAMA Pediatrics, researchers at the University of Chicago Medicine found that a low-intensity program that "prescribes" community resources to every parent or other primary caregiver of a hospitalized child reduced the use of acute care for children of food-insecure families in the following year, saving potentially thousands of dollars in healthcare expenditures while demanding little more than minutes of staff time per family.

28 Apr 2025