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Study uncovers protein that acts as a brake for DNA replication

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers.

24 Jan 2023

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

It's a good news, bad news story. Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation.

24 Jan 2023

Researchers review the association between endogenous retrovirus reactivation and aging

Researchers explored the role of endogenous retrovirus (ERV) reactivation in the aging process.

24 Jan 2023

Study compares early restrictive and liberal fluid management for sepsis-induced low pressure

Vanderbilt University Medical Center had a leading role in a large national study designed to compare two early interventions in the treatment of patients with sepsis, the body's severe response to an uncontrolled infection.

24 Jan 2023

Researchers identify a key host-cell player in COVID-19 infections

Researchers at University of California San Diego and UC Riverside have further elucidated the molecular pathway used by the SARS-CoV-2 virus to infect human lung cells, identifying a key host-cell player that may prove a new and enduring therapeutic target for treating COVID-19.

24 Jan 2023

Epidemiological evidence that Alzheimer's and Parkinson's could be caused by viral infections

A recent study published in the journal Neuron has focussed on assessing the putative associations between viral exposures and neurodegenerative disease (NDD) onset, using real-world biobank scale data.

23 Jan 2023

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Many life-saving drugs directly interact with DNA to treat diseases such as cancer, but scientists have struggled to detect how and why they work – until now.

23 Jan 2023

Aston University scientists team up with Isterian Biotech to develop novel drugs to treat fibrotic diseases

Aston University scientists are working with start-up company, Isterian Biotech, part of Cambrian BioPharma, to develop novel drugs to treat fibrotic diseases such as lung disease.

23 Jan 2023

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Immunotherapies have improved outcomes of many patients with cancer, including melanoma. But these therapies work for only a subset of patients.

23 Jan 2023

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

Hypertension drug can extend lifespan and slow aging

Researchers have found that the drug rilmenidine can extend lifespan and slow aging.

23 Jan 2023

Study reviews mechanistic data on new methods of allergy prevention and treatment

In a recent article published in Science Translational Medicine, researchers reviewed the cause and the underlying pathophysiology of allergic diseases.

23 Jan 2023

Mindfulness-type meditation intervention benefits adolescents with traumatic experiences

In 2021 alone, it is estimated that one billion children around the world experienced some kind of violence or neglect, ranging from sexual to physical or emotional abuse.

23 Jan 2023

Abortion debate ramps up in states as Congress deadlocks

Anti-abortion advocates are pressing for expanded abortion bans and tighter restrictions since the Supreme Court overturned the national right to abortion.

23 Jan 2023

Using motion capture technology and AI to monitor the progression of movement disorders

A multi-disciplinary team of researchers has developed a way to monitor the progression of movement disorders using motion capture technology and AI.

23 Jan 2023

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Scientists have worked out why common anti-depressants cause around a half of users to feel emotionally 'blunted'.

23 Jan 2023

Senolytics could be a beneficial therapeutic for COVID neuropathology

Researchers assess the effectiveness of multiple senolytic interventions in removing senescent cells in aged human brain organoids.

22 Jan 2023

New resource of digital microbes created with focus on drug metabolism

Researchers at University of Galway associated with APC Microbiome Ireland, a world-leading SFI Research Centre, have created a resource of over 7,000 digital microbes – enabling computer simulations of how drug treatments work and how patients may respond.

20 Jan 2023

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

A four-drug chemotherapy regimen provided longer overall survival than a two-drug combination in a Phase 3 clinical trial for metastatic pancreatic ductal adenocarcinoma.

20 Jan 2023

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Adding nab-paclitaxel to a standard treatment of gemcitabine plus cisplatin does not significantly extend median overall survival (OS) time for patients with advanced biliary tract cancers, although it may provide a benefit for subsets of patients with locally advanced disease or gallbladder adenocarcinoma.

20 Jan 2023

Drugs News and Research

Study uncovers protein that acts as a brake for DNA replication

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

Researchers review the association between endogenous retrovirus reactivation and aging

Study compares early restrictive and liberal fluid management for sepsis-induced low pressure

Researchers identify a key host-cell player in COVID-19 infections

Epidemiological evidence that Alzheimer's and Parkinson's could be caused by viral infections

DNA sequencing method detects where and how small molecule drugs interact with the targeted genome

Aston University scientists team up with Isterian Biotech to develop novel drugs to treat fibrotic diseases

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

Hypertension drug can extend lifespan and slow aging

Study reviews mechanistic data on new methods of allergy prevention and treatment

Mindfulness-type meditation intervention benefits adolescents with traumatic experiences

Abortion debate ramps up in states as Congress deadlocks

Using motion capture technology and AI to monitor the progression of movement disorders

Scientists reveal why common anti-depressants cause emotional ‘blunting’ in users

Senolytics could be a beneficial therapeutic for COVID neuropathology

New resource of digital microbes created with focus on drug metabolism

Four-drug chemotherapy regimen provides longer overall survival for metastatic pancreatic ductal adenocarcinoma

Addition of nab-paclitaxel to gemcitabine/cisplatin does not improve overall survival of patients with advanced biliary tract cancers

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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