Therapeutics News and Research

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Immune response to parasite varies depending on what time infection occurs, study shows

Does the time of day matter when our body is infected by a parasite? According to new research from McGill University, it matters a great deal.

11 Sep 2017

Drugs used for treatment of high cholesterol may benefit patients with cirrhosis

Statins used for the treatment of high cholesterol may have other beneficial effects, but there has been reluctance to prescribe them to patients with liver disease because of concerns that they may cause abnormal liver enzyme levels in the blood.

11 Sep 2017

G:BOX Chemi XX6 imaging system used to analyze how bacteria react to stressors

Syngene, a world-leading manufacturer of image analysis solutions, is pleased to announce its G:BOX Chemi XX6 multi-application imager is being utilized by scientists at the University of Warwick to rapidly and accurately analyze how Gram positive bacteria react to stressors.

From Syngene 8 Sep 2017

Researchers define how cancer drug works in cells, mice and man

Science is very good at determining how drugs work in experimental models. New research out of Dartmouth's Norris Cotton Cancer Center led by Alan Eastman, PhD, helps to bridge the gap when it comes to ensuring that drugs work by the same mechanism in human patients.

7 Sep 2017

BUSM researchers show new way to reduce skin cancer risk in redheads

Red-haired people are known for pale skin, freckles, poor tanning ability and unfortunately, an increased risk for developing skin cancer.

6 Sep 2017

Fluorescent dye imaging tool lights up benign brain tumors during surgery

An experimental imaging tool that uses a targeted fluorescent dye successfully lit up the benign brain tumors of patients during removal surgery, allowing surgeons to identify tumor tissue, a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania shows.

6 Sep 2017

Researchers demystify interdomain communication pathway in Hsp70 protein

Using a combination of computational and experimental techniques, a research team at the University of Massachusetts Amherst led by molecular biologist Lila Gierasch has demystified the pathway of interdomain communication in a family of proteins known as Hsp70s - a top target of dozens of research laboratories trying to develop new anti-cancer drugs, antibiotics and treatments for Alzheimer's and Parkinson's diseases.

30 Aug 2017

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice.

28 Aug 2017

Astex celebrates as breast cancer drug gets European marketing approval

Astex Pharmaceuticals, a pharmaceutical company dedicated to the discovery and development of novel small molecule therapeutics for oncology and diseases of the central nervous system, announced today that its long-standing pharmaceutical collaborator, Novartis, has received marketing approval in Europe for Kisqali (ribociclib) plus an aromatase inhibitor as a first-line treatment in post-menopausal women with hormone receptor positive, human epidermal growth factor receptor-2 negative (HR+/HER2-) locally advanced or metastatic breast cancer.

26 Aug 2017

Researchers use zebrafish animal model to explore drug-seeking behavior

As the opioid crisis escalates, the science behind addiction remains poorly understood. To address this need, researchers at University of Utah Health devised a system that allowed zebrafish, a small tropical fish, to self-administer doses of hydrocodone, an opioid commonly prescribed to people for pain.

26 Aug 2017

NIH grant for CWRU professors could enable new directions for cancer immunotherapies

Nicole Steinmetz, PhD, Associate Professor of Biomedical Engineering, Radiology, member of the Case Comprehensive Cancer Center and the Center for RNA Science and Therapeutics in the Division of General Medical Sciences at Case Western Reserve University School of Medicine and the holder of the George J. Picha Designated Professor in Biomaterials, has received a major grant from the National Institutes of Health to help understand how a virus-like particle from plants stimulates potent anti-tumor responses.

26 Aug 2017

Use of antiseptic mouthwash could put patients at risk for CVD

Nathan Bryan, Ph.D., one of the world's leading experts on the critically important role of Nitric Oxide (NO) in the health of many of the body's organs and systems, said," understanding the vital effects of bacteria in the mouth is essential for health care providers, although it is not widely understood by the public."

26 Aug 2017

Researchers aim to develop dynamic therapeutics for combating antiviral drug resistance

Antiviral drug resistance has long been a problem in modern society. As viruses evolve, they develop resistance to antiviral drugs, which become less effective at treating diseases such as influenza.

24 Aug 2017

London Freemasons award grant to medical charity to support scientists looking to cure brain tumors

Pioneering charity Brain Tumour Research has been awarded a £150,000 grant over three years by London Freemasons.

24 Aug 2017

Benefits of charcoal-based dentifrices for oral hygiene still unproven

The growing visibility of charcoal and charcoal-based dentifrices, including many that are offered for sale on the Internet, raises questions about the re-emerging practice of brushing teeth with products containing charcoal.

24 Aug 2017

High level of heart disease pipeline innovation could bridge unmet need in treating CVD

With over 1,400 products in active development, the innovation pipeline for cardiovascular disease (CVD) is extensive, with four key CVD indications – hypertension, heart failure, dyslipidemia and thrombosis – now accounting for around half of all pipeline innovation, according to GBI Research, a recognized leader in providing business information and analytics.

24 Aug 2017

Researchers visually capture 'shapeshifter' that regulates blood clotting

We are normally born with a highly sophisticated array of molecules that act as "sentries," constantly scanning our bodies for injuries such as cuts and bruises.

23 Aug 2017

Exclusive enteral nutrition may be effective treatment for children with Crohn's disease

An analysis of published studies indicates that exclusive enteral nutrition (EEN)—when individuals receive only liquid nutrition—may be an effective treatment for children with Crohn's disease. The findings are published in Alimentary Pharmacology & Therapeutics.

23 Aug 2017

‘Breakthrough’ leukemia drug also portends ‘quantum leap’ in cost

When doctors talk about a new leukemia drug from Novartis, they ooze enthusiasm, using words like "breakthrough," "revolutionary" and "a watershed moment."

23 Aug 2017

Mayo Clinic study reveals link between senescent cells and bone loss in mice

Mayo Clinic researchers have reported a causal link between senescent cells - the cells associated with aging and age-related disease - and bone loss in mice.

21 Aug 2017

Therapeutics News and Research

Immune response to parasite varies depending on what time infection occurs, study shows

Drugs used for treatment of high cholesterol may benefit patients with cirrhosis

G:BOX Chemi XX6 imaging system used to analyze how bacteria react to stressors

Researchers define how cancer drug works in cells, mice and man

BUSM researchers show new way to reduce skin cancer risk in redheads

Fluorescent dye imaging tool lights up benign brain tumors during surgery

Researchers demystify interdomain communication pathway in Hsp70 protein

Simultaneous treatment with anti-PD1 and anti-OX40 cancer therapies may have detrimental effect

Astex celebrates as breast cancer drug gets European marketing approval

Researchers use zebrafish animal model to explore drug-seeking behavior

NIH grant for CWRU professors could enable new directions for cancer immunotherapies

Use of antiseptic mouthwash could put patients at risk for CVD

Researchers aim to develop dynamic therapeutics for combating antiviral drug resistance

London Freemasons award grant to medical charity to support scientists looking to cure brain tumors

Benefits of charcoal-based dentifrices for oral hygiene still unproven

High level of heart disease pipeline innovation could bridge unmet need in treating CVD

Researchers visually capture 'shapeshifter' that regulates blood clotting

Exclusive enteral nutrition may be effective treatment for children with Crohn's disease

‘Breakthrough’ leukemia drug also portends ‘quantum leap’ in cost

Mayo Clinic study reveals link between senescent cells and bone loss in mice

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