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Researchers design armored immune cells to attack recurring cancer in liver transplant patients

Duke-NUS Medical School researchers, together with collaborators in Singapore, have designed armored immune cells that can attack recurring cancer in liver transplant patients, while temporarily evading immunosuppressant drugs patients take to avoid organ rejection.

19 Jan 2021

Memory B cell response to SARS-CoV-2 evolves up to 6 months after infection, study finds

A new study shows that the memory B cell response to SARS-Cov-2 evolves between 1.3 and 6.2 months after infection in a manner that is consistent with antigen persistence.

19 Jan 2021

Which SARS-CoV-2 mutations can potentially evade antibody recognition?

A team of US-based researchers has systematically identified SARS-CoV-2 mutations that could potentially evade neutralizing antibodies produced by the current vaccine candidates.

19 Jan 2021

Study explores how choice of foods influences aging and lifespan in fruit flies

Having a choice of foods may accelerate aging and shorten the lifespan of fruit flies, according to a study published today in the open-access eLife journal.

19 Jan 2021

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

A new study by US-based researchers describes the results of a study on the immune response among healthcare workers, in particular, their T cell responses predating the pandemic.

19 Jan 2021

Large study finds SARS-CoV-2 viral load is lowest in children

A new study by researchers in the Netherlands confirms the hypothesis that for SARS-CoV-2 infection, higher age is associated with increased viral loads.

19 Jan 2021

N501Y mutation may be associated with higher viral load, says preliminary study

A new preprint research paper posted to the medRxiv server deals with the preliminary results of a study on the so-called British variant, UI-202012/01, also known as lineage B.1.1.7 or 20B/501Y.V1.

19 Jan 2021

Genomics reveals distinct patterns of emergence of SARS‐CoV‐2 spike variants in Columbus, Ohio

Recently researchers from the United States reported the results of a SARS‐CoV‐2 genomic surveillance conducted between April 2020 and January 2021 in Columbus, Ohio. Their work is released as a preprint on the bioRxiv server.

18 Jan 2021

About 60 percent of SARS-CoV-2 cases in England tied to new variant by the end of December

One new SARS-CoV-2 variant of concern, called 202012/01, started to spread in England in late October. A new study published on the pre-print server medRxiv found that 60 percent of daily COVID-19 cases screened by the Alderley Park Lighthouse Labs were tied to 202012/01, also known as lineage B.1.1.7 or 20B/501Y.V1. This suggests a rapid spread of the new variant across the country.

18 Jan 2021

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines

Now, researchers at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom, reveal that engineered closed S constructs may be valuable immunogens that can induce neutralizing antibodies against a different pattern of epitopes. This allows for the flexibility of vaccines at both the individual and population levels.

18 Jan 2021

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Researchers in China have conducted a study showing that a carbohydrate found in the seaweed Ecklonia kurome blocks the activity of an enzyme that is essential for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

18 Jan 2021

Two common blood pressure drugs are not tied to increased risk of COVID-19

Research published in the peer-reviewed journal The Lancet Digital Health and co-led by a UCLA Fielding School of Public Health faculty member has found that two widely used types of blood pressure drugs are not tied to an increased risk of COVID-19 infection or complications.

18 Jan 2021

Study finds new evidence about the positive role of androgens in breast cancer treatment

Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease.

18 Jan 2021

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

A new study suggests that modified natural killer cells, which express a chimeric antigen receptor using S309 antibody, can bind to and inactivate SARS-CoV-2 spike protein in vitro.

18 Jan 2021

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

The potentially deadly COVID-19 has not affected animals with corresponding severity. To understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new study indicates that this may not be a faithful model of human lethal infection with SARS-CoV-2.

18 Jan 2021

Treating post-infectious smell loss in COVID-19 patients

News-Medical catches up with Professor Carl Philpott about the latest findings regarding COVID-19 and smell loss.

18 Jan 2021

NK and T cell subsets show distinctive lung-homing receptor profiles in COVID-19 patients

A new study reveals in detail the changes that occur in peripheral blood natural killer (NK) and T cells in COVID-19.

18 Jan 2021

Study: Fibroblast hormone promotes movement of hematopoietic stem cells

Discovery expected to contribute towards more effective methods of harvesting stem cells from bone marrow donors.

17 Jan 2021

Study sheds light on the causes of debilitating gut pain

A new study, published in the journal Nature, reports evidence from mice and humans that a novel mechanism contributes to chronic gut pain.

17 Jan 2021

A high-temperature tolerant SARS-CoV-2 derived immunogen as a potential vaccine candidate

There have been significant efforts worldwide to combat COVID-19, the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One prominent strategy has been to develop vaccines against the virus. Numerous vaccine candidates are under development, and a handful have now been approved for use by several countries.

17 Jan 2021

Receptor News and Research

Researchers design armored immune cells to attack recurring cancer in liver transplant patients

Memory B cell response to SARS-CoV-2 evolves up to 6 months after infection, study finds

Which SARS-CoV-2 mutations can potentially evade antibody recognition?

Study explores how choice of foods influences aging and lifespan in fruit flies

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

Large study finds SARS-CoV-2 viral load is lowest in children

N501Y mutation may be associated with higher viral load, says preliminary study

Genomics reveals distinct patterns of emergence of SARS‐CoV‐2 spike variants in Columbus, Ohio

About 60 percent of SARS-CoV-2 cases in England tied to new variant by the end of December

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Two common blood pressure drugs are not tied to increased risk of COVID-19

Study finds new evidence about the positive role of androgens in breast cancer treatment

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

Treating post-infectious smell loss in COVID-19 patients

NK and T cell subsets show distinctive lung-homing receptor profiles in COVID-19 patients

Study: Fibroblast hormone promotes movement of hematopoietic stem cells

Study sheds light on the causes of debilitating gut pain

A high-temperature tolerant SARS-CoV-2 derived immunogen as a potential vaccine candidate

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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