Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Covidien supports FDA labeling changes for gadolinium-based contrast agents

Covidien, a leading global provider of healthcare products, today announced it supports the U.S. Food and Drug Administration's (FDA) labeling changes for gadolinium-based contrast agents for patients with acute kidney injury or chronic, severe kidney disease.

13 Sep 2010

Clinica of Virginia offers medical services to Medicare and Medicaid patients for $1.00

In an effort to promote wellness and help those who are struggling to make ends meet, Clinica of Virginia, LLC. is providing quality medical services to Medicare and Medicaid patients for only $1.00. The national economic downturn, combined with national bureaucracy, has created a shortage of physicians and clinics who accept Medicare and Medicaid. Chronic, multiple medical conditions plague those Americans who can financially afford it the least, and physicians' offices who accept Medicare or Medicaid are now far and few between. Clinica accepts both.

10 Sep 2010

Lantheus Medical Imaging supports FDA action to ensure appropriate use of gadolinium-based contrast agents

Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic medical imaging, supports the U.S. Food and Drug Administration's (FDA) announcement requiring safety-related label changes for all gadolinium-based contrast agents to highlight the rare and potentially fatal condition known as nephrogenic systemic fibrosis (NSF).

10 Sep 2010

GBCAs carry new warnings on their labels about risk of NSF: FDA

The U.S. Food and Drug Administration is requiring that gadolinium-based contrast agents (GBCAs) carry new warnings on their labels about the risk of a rare and potentially fatal condition known as nephrogenic systemic fibrosis, if the drug is administered to certain patients with kidney disease.

10 Sep 2010

Translational Research issue focuses field of stem cell research, therapy

The use of stem cells for research and their possible application in the treatment of disease are hotly debated topics. In a special issue of Translational Research published this month an international group of medical experts presents an in-depth and balanced view of the rapidly evolving field of stem cell research and considers the potential of harnessing stem cells for therapy of human diseases including cardiovascular diseases, renal failure, neurologic disorders, gastrointestinal diseases, pulmonary diseases, neoplastic diseases, and type 1 diabetes mellitus.

10 Sep 2010

Three quarters of British adults support removal of shop displays of tobacco: Survey

Three quarters of British adults support the removal of shop displays of tobacco (73 per cent) and a complete ban on cigarette vending machines (77 per cent) according to a new survey commissioned by Cancer Research UK this weekend.

10 Sep 2010

NIH launches two research studies to examine ways to curtail childhood obesity epidemic

The National Institutes of Health is launching two major research efforts, totaling $72.5 million, to examine ways to curtail the nation's childhood obesity epidemic. One will study long-term approaches to prevent or treat childhood obesity, and the other will examine community efforts to reduce childhood obesity rates.

10 Sep 2010

Researchers find risk prediction model for VTE in cancer patients

For cancer patients, who have an increased risk of developing venous thromboembolism (VTE) due to a hyperactive blood coagulation system, there is now an enhanced risk model to predict their chance of developing blood clots, according to a recent study published today in Blood, the journal of the American Society of Hematology.

10 Sep 2010

Quercetin and ferulic acid antioxidants aggravate kidney cancer in severely diabetic rats

Scientists are calling for more research on the possibility that some supposedly healthful plant-based antioxidants - including those renowned for their apparent ability to prevent cancer - may actually aggravate or even cause cancer in some individuals. Their recommendation follows a study in which two such antioxidants - quercetin and ferulic acid - appeared to aggravate kidney cancer in severely diabetic laboratory rats. The study appears in ACS' bi-weekly Journal of Agricultural and Food Chemistry.

9 Sep 2010

Johns Hopkins Children's Center urges new screening program to improve sickle cell trait

The Johns Hopkins Children's Center top pediatrician is urging a "rethink" of a new sickle cell screening program, calling it an enlightened but somewhat rushed step toward improving the health of young people who carry the sickle cell mutation.

9 Sep 2010

Researchers demonstrate how insulin prepares cells for glucose uptake

Using high-resolution microscopy, researchers at the National Institutes of Health have shown how insulin prompts fat cells to take in glucose in a rat model. The findings were reported in the Sept. 8 issue of the journal Cell Metabolism.

9 Sep 2010

Jennerex, Transgene enter partnership to develop JX-594 product for tumor treatment

Jennerex, Inc., a private clinical-stage biotherapeutics company focused on the development and commercialization of first-in-class targeted oncolytic products for cancer, and Transgene Euronext, a bio-pharmaceutical company specialized in the development of immunotherapeutic products, today announced that they have entered into an exclusive partnership to develop and commercialize JX-594 for the treatment of solid tumors in Europe, the Commonwealth of Independent States (CIS) and the Middle East.

8 Sep 2010

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

Aurora-A kinase (AurA) is an enzyme that is hyperactive in many cancers and drives tumor cell proliferation. Several AurA inhibitors are currently being tested in clinical trials to see if they slow tumor growth. Now, researchers in the Developmental Therapeutics Program at Fox Chase Cancer Center have identified an activation signal for AurA. They report in the September 7 issue of Nature Communications that a quick increase in the calcium concentration in a cell rapidly triggers AurA kinase activity.

8 Sep 2010

Promedior initiates PRM-151 Phase 2a clinical study in prevention of scarring post glaucoma filtration surgery

Promedior, Inc., a clinical stage biotechnology company developing novel therapies to treat fibrotic and inflammatory diseases, announced today that it has initiated a Phase 2a clinical study of PRM-151 to evaluate the efficacy, safety, and tolerability of PRM-151 in preventing post-surgical scarring in glaucoma patients following glaucoma filtration surgery. There currently are no approved drugs for preventing post-surgical scarring in glaucoma, and there are no approved anti-fibrotic drug therapies in the U.S. or Europe for any fibrotic disease.

7 Sep 2010

Risk of late onset TRAS in living unrelated donor kidney recipients

Patients who have received a new kidney are significantly more likely to develop transplant renal artery stenosis (TRAS) if they are obese or over 50, according to research published in the September issue of the Journal of Renal Care.

7 Sep 2010

Genetic predisposition reduces breast, ovarian cancer risk with preventive surgeries: Study

A long-term study of women with a genetic predisposition for breast or ovarian cancer showed that those who elected major preventive surgeries had a significantly reduced risk of those cancers.

4 Sep 2010

Tibotec submits MAA for investigational HIV drug TMC278 to European Medicines Agency

Tibotec Pharmaceuticals today announced its submission of a Marketing Authorisation Application (MAA) to the European Medicines Agency (EMA) for TMC278 (rilpivirine, as hydrochloride), an investigational non-nucleoside reverse transcriptase inhibitor (NNRTI) for the treatment of HIV. The proposed indication would make TMC278 available for once-daily use with other antiretroviral agents in treatment-naive HIV-1-infected adults.

3 Sep 2010

Fibrosis with inflammation after one year predicts risk of long-term kidney transplant failure

Kidney transplants that show a combination of fibrosis (scarring) and inflammation after one year are at higher risk of long-term transplant failure, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

3 Sep 2010

Study establishes critical roles for cancer-causing Myc gene in stem cell biology

Stem cells might be thought of as trunks in the tree of life. All multi-cellular organisms have them, and they can turn into a dazzling variety other cells-kidney, brain, heart or skin, for example. One class, pluripotent stem cells, has the capacity to turn into virtually any cell type in the body, making them a focal point in the development of cell therapies, the conquering of age-old diseases or even regrowing defective body parts.

3 Sep 2010

Researchers identify two proteins in cellular response to mechanical stimulation

Scripps Research Institute scientists have identified two proteins with potential to be important targets for research into a wide range of health problems, including pain, deafness, and cardiac and kidney dysfunction.

3 Sep 2010

Nephrology News and Research

Further Reading

Covidien supports FDA labeling changes for gadolinium-based contrast agents

Clinica of Virginia offers medical services to Medicare and Medicaid patients for $1.00

Lantheus Medical Imaging supports FDA action to ensure appropriate use of gadolinium-based contrast agents

GBCAs carry new warnings on their labels about risk of NSF: FDA

Translational Research issue focuses field of stem cell research, therapy

Three quarters of British adults support removal of shop displays of tobacco: Survey

NIH launches two research studies to examine ways to curtail childhood obesity epidemic

Researchers find risk prediction model for VTE in cancer patients

Quercetin and ferulic acid antioxidants aggravate kidney cancer in severely diabetic rats

Johns Hopkins Children's Center urges new screening program to improve sickle cell trait

Researchers demonstrate how insulin prepares cells for glucose uptake

Jennerex, Transgene enter partnership to develop JX-594 product for tumor treatment

Quick increase of calcium concentration in cells rapidly trigger Aurora-A kinase enzyme activity

Promedior initiates PRM-151 Phase 2a clinical study in prevention of scarring post glaucoma filtration surgery

Risk of late onset TRAS in living unrelated donor kidney recipients

Genetic predisposition reduces breast, ovarian cancer risk with preventive surgeries: Study

Tibotec submits MAA for investigational HIV drug TMC278 to European Medicines Agency

Fibrosis with inflammation after one year predicts risk of long-term kidney transplant failure

Study establishes critical roles for cancer-causing Myc gene in stem cell biology

Researchers identify two proteins in cellular response to mechanical stimulation

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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