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Research paves way for safer and more effective drugs to treat type 2 diabetes

Research led by the University of Adelaide is paving the way for safer and more effective drugs to treat type 2 diabetes, reducing side effects and the need for insulin injections.

18 May 2017

Spanish scientists develop promising gene therapy method to treat Wilson's disease

Scientists at the Center for Applied Medical Research at the University of Navarra have designed a promising gene therapy method to treat Wilson's disease, a rare pathology caused by the lack of or malfunction of a gene.

16 May 2017

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

A study published now on Nature Communications shows that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive.

16 May 2017

Prototype drug prevents lung cancer tumors in mice by using novel mechanism

Lung cancer tumors were prevented in mice by a novel small molecule that directly activates a tumor suppressor protein.

16 May 2017

WSU scientists develop new approach to deliver therapeutics to tumors

For the first time, WSU researchers have demonstrated a way to deliver a drug to a tumor by attaching it to a blood cell. The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues.

16 May 2017

Research could lead to development of new therapies that reduce pathological fear in PTSD

Research published by scientists at the University of California, Riverside on "fear memory" could lead to the development of therapies that reduce the effects of post-traumatic stress disorder (PTSD).

16 May 2017

COSMIC'S new 3D system can help identify and characterize cancer drug targets

COSMIC-3D, the most comprehensive system for exploring cancer mutations in three dimensions, is launched today by COSMIC, based at the Wellcome Trust Sanger Institute, in collaboration with Astex Pharmaceuticals, Cambridge, UK.

15 May 2017

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.

12 May 2017

Boosting clinical trial research in London

Richmond Pharmacology have opened their fourth clinical trial facility and the new site has been used for this type of work for more than 30 years. It's in an ideal location embedded in the University and teaching hospital campus.

11 May 2017

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced an exclusive, global collaboration and license agreement for the development and commercialization of gene therapy programs for Hemophilia A, including SB-525, one of Sangamo's four lead product candidates, which Sangamo expects will enter the clinic this quarter.

11 May 2017

Penn researcher searches for common factor linked to smell loss

Studies have shown that loss of the sense of smell can be among the first warning signs of diseases such as Alzheimer's and Parkinson's.

10 May 2017

UC researchers find stem cell vaccine to enhance immune responses against tumors in animal models

Researchers at the University of Cincinnati have found that a cancer stem cell vaccine, engineered to express a pro-inflammatory protein called interleukin-15 (IL-15) and its receptor (IL-15Ralpha), caused T cell production in animal models and enhanced immune responses against tumors.

10 May 2017

New findings pinpoint key feature of rare childhood disease that could help fast-track diagnosis

Australian scientists have shown, for the first time, that a family of untethered proteins builds up in the cells of children with a rare and serious genetic condition, known as mevalonate kinase deficiency (MKD).

10 May 2017

Researchers find many postmarket safety events after FDA approval of new drugs

How often are safety concerns raised about a drug after it's been approved by the FDA? Nicholas Downing, MD, of the Department of Medicine at Brigham and Women's Hospital, and colleagues have found that for drugs approved between 2001 and 2010, nearly 1 in 3 had a postmarket safety event.

9 May 2017

Stress management may be promising strategy to treat abdominal pain in IBD patients

When researchers analyzed published studies on how to treat recurrent abdominal pain among patients with inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis, stress management appeared to be a promising strategy.

9 May 2017

Machine learning algorithm can help predict progression of age-related macular degeneration

Scientists have demonstrated that a machine learning algorithm, using images of patients' retinas obtained over time, can predict the critical moment when early or intermediate age-related macular degeneration (AMD) will progress into severe AMD.

8 May 2017

Texas A&M researchers aim to develop one drug that treats pain, memory and nicotine addiction

Although pain, memory and nicotine addiction may not seem to be related, they actually share a common player: the nicotinic acetylcholine receptors.

5 May 2017

Researchers find new way to make influenza visible to the naked eye

Researchers at the University of Notre Dame have discovered a way to make influenza visible to the naked eye, according to a new study in the Journal of the American Chemical Society.

5 May 2017

Study reveals critical role of omega-3 fatty acids in preserving integrity of the blood-brain barrier

Already extolled for their health benefits as a food compound, omega-3 fatty acids now appear to also play a critical role in preserving the integrity of the blood-brain barrier, which protects the central nervous system from blood-borne bacteria, toxins and other pathogens, according to new research from Harvard Medical School.

5 May 2017

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Neuroscientists at Tufts University School of Medicine have discovered a new signaling pathway that directly connects two major receptors in the brain associated with learning and memory – the N-methyl-D-aspartate receptor (NMDAR) and the alpha 7 nicotinic acetylcholine receptor (a7nAChR) – which has significance for current efforts to develop drugs to treat schizophrenia.

4 May 2017

Therapeutics News and Research

Research paves way for safer and more effective drugs to treat type 2 diabetes

Spanish scientists develop promising gene therapy method to treat Wilson's disease

Breast cancer cells undergo stiffening state prior to becoming malignant, study shows

Prototype drug prevents lung cancer tumors in mice by using novel mechanism

WSU scientists develop new approach to deliver therapeutics to tumors

Research could lead to development of new therapies that reduce pathological fear in PTSD

COSMIC'S new 3D system can help identify and characterize cancer drug targets

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

Boosting clinical trial research in London

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Penn researcher searches for common factor linked to smell loss

UC researchers find stem cell vaccine to enhance immune responses against tumors in animal models

New findings pinpoint key feature of rare childhood disease that could help fast-track diagnosis

Researchers find many postmarket safety events after FDA approval of new drugs

Stress management may be promising strategy to treat abdominal pain in IBD patients

Machine learning algorithm can help predict progression of age-related macular degeneration

Texas A&M researchers aim to develop one drug that treats pain, memory and nicotine addiction

Researchers find new way to make influenza visible to the naked eye

Study reveals critical role of omega-3 fatty acids in preserving integrity of the blood-brain barrier

Discovery of signaling pathway offers new functional framework for treating schizophrenia

Understanding the DNA Damage Response in Innate Immunity eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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