Cell Line News and Research

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What happens when microplastics reach the testes? Study shows autophagy and cell loss

Researchers found that microplastics from everyday plastic tableware accumulate in human semen and, although not linked to semen quality in the full cohort, were associated with altered sperm parameters in specific subgroups. Experimental models confirmed that 50 nm polystyrene particles trigger autophagy and apoptosis via the FOXA1/MAP3K1/p38 pathway, impairing sperm structure and function.

15 Oct 2025

Discovery reveals hidden differences in herpes virus cultures

Matthew Taylor likened his recently published work alongside doctoral student Gary Dunn to kicking over a rock. Once the discovery was made, it was time to see what lay beneath.

3 Oct 2025

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Ferroptosis, a regulated cell death mechanism, is emerging as a promising target for cancer therapy. The process is mediated by the activity of acyl-CoA synthetase family member 4 (ACSL4) protein.

22 Sep 2025

Digital twin of lung cancer cell offers new insights into tumor growth and treatment

An enhanced computer model is now helping to provide fresh insights into cancer-cell growth and how it can be stopped. The digital cell model represents another step towards individualized cancer treatment.

18 Sep 2025

HIIT boosts anti-cancer proteins and slows breast cancer growth

Both resistance training and HIIT enhance myokine levels and suppress breast cancer cell growth, supporting exercise as a therapeutic strategy for survivors.

15 Sep 2025

Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer

Urothelial carcinoma (UC) is the second most common genitourinary cancer, leading to over 16,000 deaths a year in the United States. Despite recent advances, the 5-year survival rate for metastatic UC remains around five to ten percent.

12 Sep 2025

Axxam and B'SYS partner to expand access to validated ion channel cell lines for high-throughput electrophysiology

Axxam S.p.A., a premier provider of integrated early drug discovery services, and B'SYS GmbH, a specialist in ion channel biology, are pleased to announce a strategic collaboration focused on enabling access to validated ion channel cell lines for hit and lead identification through high-throughput electrophysiological screening.

From Axxam S.p.A 8 Sep 2025

New technology embeds unique genetic identifiers in engineered cells

Genetically engineered cell lines used in biomedical research have long been prone to misidentification and unauthorized use, wasting billions of dollars each year and jeopardizing critical scientific discoveries.

5 Sep 2025

BioDlink expands ecosystem alliance to empower biotech innovators worldwide

As BioDlink, a leading global CDMO, affirms its commitment to strategic alliances to support biotech innovation worldwide as it marks 15 years of operations.

From BioDlink 5 Sep 2025

Fluidic Sciences acquires business and assets of Sphere Bio to accelerate single-cell and protein interaction discovery

Fluidic Sciences Ltd, a leader in in‑solution protein interaction analysis, today announced it has purchased the business and assets of Sphere Bio Ltd.

5 Sep 2025

HER2 and CD24 emerge as promising radiotheranostic targets in endometrial cancer

Two molecular targets-human epidermal growth factor 2 (HER2) and cluster of differentiation 24 (CD24)-are highly promising candidates for new nuclear diagnostics and therapeutics for endometrial cancer, according to new research published in The Journal of Nuclear Medicine.

5 Sep 2025

New method uncovers how extracellular vesicles impact immune response in cancer

Certain types of biochemical processes can impair the immune system's ability to recognize and kill cancer cells. Purdue University's W. Andy Tao and his associates have developed a new way to study these processes.

26 Aug 2025

Epstein-Barr virus protein enhances cancer gene activity in HPV-positive cervical cells

A new research paper was published in Volume 16 of Genes & Cancer on August 6, 2025, titled "Epstein-Barr virus nuclear antigen 1 upregulates Derlin1 and PSMD10 expression in HeLa cells."

22 Aug 2025

Nanodroplet array revolutionizes search for new drugs

Until now, the early phase of drug discovery for the development of new therapeutics has been both cost- and time-intensive.

21 Aug 2025

Curcumin activates SIRT3 to protect bone structure in diabetic mice

In a new Scientific Reports study, curcumin protected bone-forming cells from high-glucose damage by activating the SIRT3/FoxO3a/NRF2 antioxidant pathway and restoring mitochondrial health. In diabetic mice, curcumin improved bone density and oxidative balance, highlighting its potential in osteoporosis prevention.

13 Aug 2025

mRNA vaccine shows potent efficacy in gastric cancer

Gastric cancer is one of the leading causes of cancer-related mortality worldwide, and peritoneal metastasis, wherein the cancer spreads to the peritoneum or the lining of the abdominal cavity, represents the most common form of recurrence after gastric cancer surgery.

13 Aug 2025

Nudibranchs (sea slugs) emerge as a promising source of cancer drugs

Researchers reviewed the antitumor potential of bioactive compounds from nudibranchs, marine mollusks that acquire or synthesize potent chemical defenses. These compounds, often sourced from their diet, show promising cancer-fighting activity through mechanisms like DNA damage, oxidative stress, and apoptosis.

12 Aug 2025

Brain’s energy control map offers blueprint for next-gen weight loss therapies

Scientists map how the brain integrates hormonal and neural signals from the body to control appetite, energy use, and reward pathways, revealing targets for next-generation anti-obesity drugs. This review highlights the interplay between neuroendocrine circuits, neuroplasticity, and pharmacotherapy for durable, non-aversive weight loss.

11 Aug 2025

Starfish compound overcomes drug resistance in prostate cancer models

Researchers identified that triterpene glycosides from the starfish Solaster pacificus can kill drug-resistant prostate cancer cells in vitro by bypassing common resistance pathways. CuC1 showed synergy with existing chemotherapies, though with only moderate selectivity for cancer cells.

5 Aug 2025

Lipid droplet protein perilipin 2 linked to poor prognosis in lung cancer

New research has revealed that perilipin 2 protein modulates aggressive cancer progression in advanced lung adenocarcinoma, the most common type of lung cancer, by regulating lipid droplet accumulation, which plays an important role in lipid metabolism by making cancer cells store more fat, acting as a fuel source.

5 Aug 2025

Cell Line News and Research

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Discovery reveals hidden differences in herpes virus cultures

PRMT5 inhibition induces ferroptosis and enhances immunotherapy efficacy in renal cell carcinoma

Digital twin of lung cancer cell offers new insights into tumor growth and treatment

HIIT boosts anti-cancer proteins and slows breast cancer growth

Repurposed diabetes drugs boost CAR T therapy effectiveness in bladder cancer

Axxam and B'SYS partner to expand access to validated ion channel cell lines for high-throughput electrophysiology

New technology embeds unique genetic identifiers in engineered cells

BioDlink expands ecosystem alliance to empower biotech innovators worldwide

Fluidic Sciences acquires business and assets of Sphere Bio to accelerate single-cell and protein interaction discovery

HER2 and CD24 emerge as promising radiotheranostic targets in endometrial cancer

New method uncovers how extracellular vesicles impact immune response in cancer

Epstein-Barr virus protein enhances cancer gene activity in HPV-positive cervical cells

Nanodroplet array revolutionizes search for new drugs

Curcumin activates SIRT3 to protect bone structure in diabetic mice

mRNA vaccine shows potent efficacy in gastric cancer

Nudibranchs (sea slugs) emerge as a promising source of cancer drugs

Brain’s energy control map offers blueprint for next-gen weight loss therapies

Starfish compound overcomes drug resistance in prostate cancer models

Lipid droplet protein perilipin 2 linked to poor prognosis in lung cancer

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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