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Fondazione Telethon achieves milestone with Waskyra approval for Wiskott-Aldrich Syndrome

Fondazione Telethon announces the positive opinion issued by the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommending marketing authorization in the European Union for Waskyra, an ex vivo gene therapy for Wiskott-Aldrich Syndrome (WAS), a rare and life-threatening primary immunodeficiency.

14 Nov 2025

Enhancing the cancer-immunity cycle through innovative vaccines

Therapeutic cancer vaccines have experienced a remarkable resurgence over the past decade, representing a paradigm shift in oncology toward harnessing the immune system's intrinsic ability to combat malignancies.

14 Nov 2025

Alzheimer’s breakthrough reveals how tweaking one gene shields brain connections

Lowering the transcription factor PU.1 reprograms microglia into a neuroprotective, lymphoid-like state that compacts amyloid, blocks tau spread, and preserves synapses in Alzheimer’s disease. Microglial CD28 signaling helps restrain inflammation, revealing a regulatory switch that may inform future immunotherapies targeting microglia rather than neurons.

6 Nov 2025

Urolithin A recharges aging immune cells and boosts mitochondrial fitness in midlife adults

Urolithin A, a natural postbiotic known to trigger mitophagy, rejuvenated key immune cell functions in healthy middle-aged adults after 28 days. The trial showed a shift toward a youthful, energy-efficient CD8⁺ T-cell profile and enhanced bacterial clearance without inflammatory side effects.

3 Nov 2025

Pioneering technology enables scalable production of human kidney organoids

A research team led by the Institute for Bioengineering of Catalonia (IBEC) and collaborating with the Biomedical Research Institute of A Coruña (INIBIC), as well as other international research groups, has developed pioneering technology that enables human kidney organoids to be produced in a scalable manner.

31 Oct 2025

Gene therapy shows long-term success in children with rare immune disorder

Results from the largest cohort of children who received a gene therapy for a rare immunodeficiency condition have shown the long-term safety and efficacy of the curative treatment, in a study led by a UCL researcher.

15 Oct 2025

Scientists revive diabetic beta cells, revealing a new path to restore insulin function

Researchers demonstrated that pancreatic β cells from type 2 diabetes donors can partially regain glucose responsiveness when cultured outside the diabetic environment. This recovery, driven by specific gene expression changes, identifies JAK inhibitors as potential therapeutic candidates to restore β-cell function.

14 Oct 2025

Study offers new models for understanding the causes of chemo brain

Cancer is a challenging enough diagnosis, but many patients are dealt a second blow, even as they heal: "chemo brain."

13 Oct 2025

Microplastics can alter the human gut microbiome, research shows

New research presented today at UEG Week 2025 shows that microplastics – plastic particles smaller than 5mm commonly found in the environment – can alter the human gut microbiome, with some changes resembling patterns linked to depression and colorectal cancer.

6 Oct 2025

Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

The mechanical properties of tissue matrix are crucial for maintaining cell health and function. With aging, tissue matrix loses its mechanical integrity and exhibits altered biophysical properties, which are closely associated with various diseases including neurodegenerative diseases and cancers.

30 Sep 2025

Calcium-induced release identified as key driver of dangerous muscle disorders

Researchers engineered mice with a mutation (E3896A) in the RyR1 calcium-binding site, eliminating calcium-induced calcium release (CICR) without affecting depolarization-induced calcium release.

25 Sep 2025

SynGenSys introduces NK.SET synthetic promoter library to advance natural killer cell therapies

SynGenSys, a biotechnology company designing synthetic gene promoter systems to address critical bottlenecks in biopharma manufacturing and enhance cell and gene therapy development, today announced the launch of NK.SET™.

23 Sep 2025

Carrot fiber supplement boosts gut bacteria and immune defenses

This trial reveals that carrot-derived rhamnogalacturonan-I boosts Bifidobacteria and supports immune function, highlighting its potential for gut health.

18 Sep 2025

Imaging breakthrough shows how spinal cord injuries affect the whole central nervous system

A new PET tracer can provide insights into how spinal cord injuries affect not only the spinal cord, but also the brain, according to new research published in The Journal of Nuclear Medicine.

13 Sep 2025

Europa Biosite announces exclusive UK & Ireland partnership between Bio X Cell and Cambridge Bioscience

Europa Biosite is pleased to announce that Bio X Cell has appointed Cambridge Bioscience, a proud member of Europa Biosite, as its exclusive distributor for the United Kingdom and Ireland.

3 Sep 2025

Single-cell transcriptomics reveals new players in liver regeneration

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes.

2 Sep 2025

New technique succeeds in studying embryo implantation outside the body

The use of assisted reproductive technologies like in vitro fertilization is becoming more common worldwide. However, while these technologies successfully create viable embryos, a little over half of all embryos are lost because they fail to implant into the uterus.

2 Sep 2025

Probiotics limit the spread of drug-resistant genes in preemies

Study reveals probiotics help preterm infants develop healthier gut microbiomes, reducing multidrug-resistant bacteria and enhancing neonatal care outcomes.

26 Aug 2025

Electromechanical reshaping could be a gentler alternative to LASIK

Millions of Americans have altered vision, ranging from blurriness to blindness. But not everyone wants to wear prescription glasses or contact lenses.

18 Aug 2025

Study shows probiotics help preterm babies fight antibiotic-resistant bacteria

Researchers found that probiotics help reduce antibiotic-resistant bacteria in the guts of very-low-birth-weight preterm infants, but cannot fully prevent resistance genes from spreading. Antibiotic use still promotes gene swapping, highlighting the limits of probiotics alone in neonatal care.

17 Aug 2025