Immunoglobulin News and Research

RSS

Advances in diagnosis and management of systemic light chain amyloidosis

Systemic light chain (AL) amyloidosis is a rare and life-threatening disorder characterized by the deposition of misfolded immunoglobulin light chains as insoluble amyloid fibrils in various tissues and organs, leading to progressive structural and functional impairment.

30 Oct 2025

Researchers uncover and inhibit a key cell death pathway in severe cutaneous adverse reactions

A collaborative research group led by Haruna Kimura (graduate student), Dr. Akito Hasegawa (Assistant Professor), and Prof. Riichiro Abe from the Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, together with Prof. Takemasa Ozawa from the Department of Chemistry, School of Science, The University of Tokyo, and Dr. Yoichi Ogawa (Lecturer) from the Department of Dermatology, Faculty of Medicine, University of Yamanashi, has developed a novel therapeutic candidate that may improve the prognosis of severe cutaneous adverse reactions such as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

24 Oct 2025

GemPharmatech collaborates with MSK Cancer Center to accelerate discovery of therapeutic antibodies

GemPharmatech, a global leader in preclinical research solutions and genetically-engineered mouse models, today announced a collaboration with Memorial Sloan Kettering Cancer Center (MSK) to accelerate the discovery of new therapeutic antibodies.

23 Oct 2025

Can introducing peanuts early prevent allergies? Real-world data confirms it helps

Using data from over 120,000 U.S. children, this Pediatrics study found that the prevalence and risk of peanut and other IgE-mediated food allergies declined significantly after the 2015 and 2017 guidelines promoting early allergen introduction. The findings support these policies as effective public health measures to prevent food allergies in real-world settings.

22 Oct 2025

Food allergy diagnoses plummet after guideline implementation

Peanuts represent one of the most common causes of immunoglobulin E (IgE)-mediated, or anaphylactic, food allergies in children, yet a landmark study found that early introduction of peanut to infants may lower their risk of developing this allergy.

21 Oct 2025

Gene therapy shows long-term success in children with rare immune disorder

Results from the largest cohort of children who received a gene therapy for a rare immunodeficiency condition have shown the long-term safety and efficacy of the curative treatment, in a study led by a UCL researcher.

15 Oct 2025

How shifting antibodies fuel aging and the new therapies aiming to slow it

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, glycosylation changes, and Fc receptor pathways, it reveals immunoglobulins as both biomarkers and potential therapeutic targets in aging.

14 Oct 2025

Multimodal nanocarriers offer targeted solutions for tumor treatment

Cancer remains a leading cause of global morbidity and mortality. Traditional therapies like chemotherapy and radiotherapy are often limited by their lack of specificity, leading to systemic toxicity and the emergence of drug resistance.

10 Oct 2025

Asthma and multiple allergies raise the risk of failed oral food challenges

Research shows asthma and multi-food allergies elevate the odds of reactions in oral food challenges, emphasizing the importance of careful patient selection.

8 Oct 2025

Common food additives may trigger childhood asthma

Researchers utilize metabolomics to investigate the mechanisms underlying the association between food additives and childhood asthma.

6 Oct 2025

Elderberry juice boosts key genes for metabolic flexibility in overweight adults

Elderberry juice intake triggers metabolic gene expression changes, enhancing glucose control and fat oxidation in overweight adults during meal challenges.

3 Oct 2025

How maternal microbes shape babies’ gut health and disease risk

Early microbial exposures from maternal microbes, milk components, and the environment shape infant gut development and long-term disease risk. The review highlights mechanisms, preventive levers, and research gaps in supporting healthy microbiome inheritance across generations.

29 Sep 2025

Scientists outline how future therapies could change type 1 diabetes care

Researchers writing in The Lancet review breakthroughs in type 1 diabetes treatment, from immunotherapies that delay onset to stem-cell β-cell replacement and automated insulin delivery. They stress that equitable access, validated surrogate endpoints, and scalable technologies are crucial for lasting impact.

24 Sep 2025

Far-UV at 222 nm disrupts common allergens and could ease asthma triggers

Far-UV radiation demonstrates a 25% reduction in airborne allergens, highlighting its promise for enhancing indoor air quality for asthma patients.

24 Sep 2025

Mediterranean diet during pregnancy cuts babies’ food allergy risk

Researchers found that mothers who closely followed a Mediterranean diet during pregnancy and breastfeeding had infants with lower odds of developing food allergies. High fruit, vegetable, and full-fat dairy intake appeared protective, while higher poultry, red meat, and fish intake during pregnancy increased risk.

15 Sep 2025