Ligand News and Research

RSS

$Biomimetic platform enhances CAR T therapy for relapsed and refractory leukemia$

Biomimetic platform enhances CAR T therapy for relapsed and refractory leukemia

Chimeric antigen receptor T (CAR T) cell therapy represents a milestone in leukemia treatment. CAR T works by genetically engineering a chimeric antigen receptor on the surface of the patient's T cells to target specific antigens on leukemia cells, with the goal of identifying and eliminating them.

9 Mar 2026

Wnt signaling in fibroblasts drives gastric cancer metastasis to the liver

Researchers at the Cancer Research Institute and the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have uncovered a critical mechanism that enables gastric cancer to spread to distant organs.

6 Mar 2026

Single injection may help the heart heal after heart attack

For people who have survived a heart attack, the notion of one shot in the arm to help the heart heal, for weeks after, may seem far‑fetched. But thanks to a team of researchers, including a Texas A&M University professor, that's exactly what could happen.

5 Mar 2026

Investigating microglia’s role in Alzheimer’s pathology

Announcing a new article publication for BIO Integration journal. Alzheimer's disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark.

1 Mar 2026

Promega unveils cellular target engagement technology aimed at expanding the druggable proteome at SLAS 2026

Promega Corporation is launching a new live-cell target engagement platform that could close a long-standing gap between biochemical and cellular assays for understudied or difficult-to-interrogate proteins.

From Promega Corporation 27 Feb 2026

Chronic inflammation shapes cancer progression and immunotherapy response

Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs, MDSCs, and Tregs-orchestrate a tumor-permissive microenvironment.

16 Feb 2026

Study explores whether a bidirectional causal link exists between MASLD and sarcopenia

Metabolic dysfunction-associated steatotic liver disease (MASLD) and sarcopenia frequently coexist, yet their causal relationship and underlying mechanisms remain poorly defined.

13 Feb 2026

Thermodynamic insights into histamine H1 receptor ligand binding

G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs.

13 Feb 2026

New strategy harnesses pre-existing antiviral immunity to boost anti-tumor responses

Because many different types of cancer cells overexpress programmed death-ligand 1 (PD-L1), this cell surface protein is a major target of cancer immunotherapy.

11 Feb 2026

Chronic alcohol use profoundly alters gene expression in the brain's reward system

Chronic alcohol consumption profoundly alters gene expression in key brain regions involved in reward, impulse control, and decision-making, according to a study led by researchers at the Institute for Neurosciences, a joint center of Miguel Hernández University of Elche (UMH) and the Spanish National Research Council (CSIC).

9 Feb 2026

RNA micelles enable targeted chemotherapy without immune toxicity

A new study in mice hints at the potential to use tiny particles made with RNA molecules to deliver chemotherapy drugs and other therapies directly to tumors, killing cancer cells without generating an immune response or toxicity-related side effects.

7 Feb 2026

Single-cell study uncovers cardiomyocyte-fibroblast signaling in ischemia-reperfusion injury

Announcing a new article publication for BIO Integration journal. Cardiac cell death and myocardial fibrosis after ischemia-reperfusion (I/R) injury are the primary causes of impaired cardiac function.

6 Feb 2026

Sapio Sciences announces partner ecosystem for ELaiN, its third-generation AI lab notebook

Sapio Sciences, the science-aware™ AI lab informatics platform, today announced the availability of trusted, third-party scientific applications and platforms now integrated directly into Sapio ELaiN, its third-generation AI lab notebook.

From Sapio Sciences 16 Jan 2026

New chemistry revives neurokinin-1 receptor as depression treatment target

For decades, scientists have investigated the neurokinin-1 receptor (NK1R) as a potential target for treating major depressive disorder.

14 Jan 2026

FairJourney Bio launches cryo-EM services with advanced laboratories in San Diego, USA

FairJourney Bio (FJBio), a leading global provider of antibody discovery and development services, today announced the expansion of its portfolio with the launch of state-of-the-art cryo-electron microscopy (cryo-EM) services, supported through the Company's advanced laboratories in San Diego, CA.

12 Jan 2026

Ligand News and Research

Biomimetic platform enhances CAR T therapy for relapsed and refractory leukemia

Wnt signaling in fibroblasts drives gastric cancer metastasis to the liver

Single injection may help the heart heal after heart attack

Investigating microglia’s role in Alzheimer’s pathology

Promega unveils cellular target engagement technology aimed at expanding the druggable proteome at SLAS 2026

Chronic inflammation shapes cancer progression and immunotherapy response

Study explores whether a bidirectional causal link exists between MASLD and sarcopenia

Thermodynamic insights into histamine H1 receptor ligand binding

New strategy harnesses pre-existing antiviral immunity to boost anti-tumor responses

Chronic alcohol use profoundly alters gene expression in the brain's reward system

RNA micelles enable targeted chemotherapy without immune toxicity

Single-cell study uncovers cardiomyocyte-fibroblast signaling in ischemia-reperfusion injury

Sapio Sciences announces partner ecosystem for ELaiN, its third-generation AI lab notebook

New chemistry revives neurokinin-1 receptor as depression treatment target

FairJourney Bio launches cryo-EM services with advanced laboratories in San Diego, USA

Researchers develop enhanced antibodies to unleash the immune system against cancer

New antibody mechanisms disrupt bacterial adhesion in urinary tract infections

Breakthrough treatment for advanced prostate cancer could eliminate severe side effects

TAAR1 mutation impairs brain signaling in schizophrenia

Repurposed drug combination shows strong promise against liver fibrosis

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

Latest News