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Tirzepatide activates brown fat, boosting metabolism beyond appetite control

Tirzepatide is one of the drugs that has revolutionized the treatment of obesity and other conditions such as diabetes in recent years.

24 Feb 2026

Gut microbiome may shape response to GLP-1 drugs, new review suggests

This review examines how GLP-1 receptor agonists and the gut microbiome influence one another through bile acid signaling, short-chain fatty acids, and inflammatory pathways. It explores how microbial composition may shape treatment response and highlights the need for controlled human studies to enable microbiome-informed precision therapy.

19 Feb 2026

Chronic inflammation shapes cancer progression and immunotherapy response

Chronic inflammation is both a driver and suppressor of cancer depending on context. Key players-NF-κB, IL-6, STAT3, TAMs, MDSCs, and Tregs-orchestrate a tumor-permissive microenvironment.

16 Feb 2026

Northwestern scientists develop advanced organoid model for human spinal cord injury

Northwestern University scientists have developed the most advanced organoid model for human spinal cord injury to date.

11 Feb 2026

New guidance for the diagnosis and management of inherited hyperbilirubinemia

Inherited hyperbilirubinemia, encompassing Gilbert syndrome, Crigler-Najjar syndrome, Dubin-Johnson syndrome, and Rotor syndrome, represents a spectrum of disorders rooted in genetic defects affecting bilirubin metabolism and transport.

10 Feb 2026

Ride Cincinnati grant funds research on immune activating wafer for glioblastoma treatment

A multidisciplinary team of University of Cincinnati Cancer Center researchers has received a $40,000 Ride Cincinnati grant to study a delayed release preparation, or wafer, of an immunostimulatory molecule to stimulate the central nervous system (CNS) immune system after surgery to remove glioblastoma, a form of primary brain cancer.

3 Feb 2026

New mode of communication inside cells helps bacterial pathogens to evade drugs

Biologists have uncovered a new mode of communication inside cells that helps bacterial pathogens learn how to evade drugs.

30 Jan 2026

AI-driven model enhances treatment decisions for cancer patients after heart attack

Cancer patients who suffer a heart attack face a dangerous mix of risks, which makes their clinical treatment particularly challenging.

30 Jan 2026

Aptamer-based wearables revolutionize continuous health tracking

Continuous monitoring of biomarkers is essential for early disease detection, treatment evaluation, and personalized health management, yet most clinical tests rely on invasive, single-point blood sampling. Recent advances in aptamer-based wearable electrochemical sensors offer a promising alternative by enabling real-time, continuous tracking of physiological signals directly in or on the body.

30 Jan 2026

How DNA and life experiences leave distinct marks on the human immune system

Using single-cell epigenomic profiling of immune cells from 110 individuals, researchers show that genetic variation and environmental exposures shape the human immune system through distinct DNA methylation mechanisms. Genetic effects concentrate within gene bodies of memory cells, while environmental exposures primarily remodel regulatory regions in naive immune cells.

28 Jan 2026

Why promising microbiome therapies rarely work in patients

Addressing the microbiome's translational gap involves understanding biological complexity and developing function-driven, patient-specific interventions.

8 Jan 2026

Brazilian study shows liquid biopsies can expedite lung cancer care

In Brazil, the early detection of genetic alterations in lung cancer through liquid biopsies could be a valuable tool for expediting diagnoses and guiding patient treatment.

7 Jan 2026

TAAR1 mutation impairs brain signaling in schizophrenia

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely silence a brain receptor that pharmaceutical companies are racing to target with new drugs.

6 Jan 2026

Unveiling Hidden Potential: Organoids for Disease Modeling in Neuroscience Research

In our latest interview, News-Medical speaks with Rosanna Zhang from ACROBiosystems about utilizing organoids for disease modeling in the field of neuroscience research.

From ACROBiosystems 6 Jan 2026

First human 'lung-on-chip' model developed using stem cells from a single donor

Researchers at the Francis Crick Institute and AlveoliX have developed the first human 'lung-on-chip' model using stem cells taken from only one person.

2 Jan 2026

Study validates OVCAR3 as a model for high-grade serous ovarian cancer

A new research paper was published in Volume 12 of Oncoscience on October 14, 2025, titled "Bridging clinical insight and laboratory model in high-grade serous ovarian carcinoma (HGSOC) using DNA sequencing-based profiling of TP53."

23 Dec 2025

How diabetes medications may influence cancer risk and progression

Diabetes, particularly Type 2 Diabetes (T2DM), has been linked to an increased risk of various cancers, including liver, colorectal, and breast cancer.

18 Dec 2025

New framework tracks response to anti-amyloid therapies in Alzheimer's

In the last few years, progress has been made in the fight against Alzheimer's disease with a class of therapies called anti-amyloid antibodies (anti-Aβ).

15 Dec 2025

Novel AI tool not only identifies genetic mutations but also predicts the type of disease

Scientists at the Icahn School of Medicine at Mount Sinai have developed a novel artificial intelligence tool that not only identifies disease-causing genetic mutations but also predicts the type of disease those mutations may trigger.

15 Dec 2025

Mass General Brigham launches AI company to enhance clinical trial matching

Mass General Brigham is announcing the spinout of AIwithCare, a company founded by researchers from the health system who developed an artificial intelligence (AI) screening tool that significantly outperformed manual screening for determining a patient's eligibility and enrolling them in a clinical trial.

12 Dec 2025