Human physiology is the science of the mechanical, physical, and biochemical functions of humans in good health, their organs, and the cells of which they are composed. The principal level of focus of physiology is at the level of organs and systems. Most aspects of human physiology are closely homologous to corresponding aspects of animal physiology, and animal experimentation has provided much of the foundation of physiological knowledge. Anatomy and physiology are closely related fields of study: anatomy, the study of form, and physiology, the study of function, are intrinsically tied and are studied in tandem as part of a medical curriculum.
Late-life semaglutide treatment slowed age-related physiological decline, attenuated multiple molecular hallmarks of aging, and extended median lifespan from 742 to 834 days in aged female mice. The drug reproduced many effects of calorie restriction while providing additional benefits in exploratory behavior, spatial memory, and glucose control, suggesting that some effects extend beyond reduced calorie intake alone.
Scientists have found that targeting a particular group of proteins in the uterus muscle (myometrium) can suppress human uterine contractions in laboratory studies and delay preterm birth in a preclinical model.
By teaching an AI system to connect raw heart signals with the clinical insights contained in cardiologists’ reports, researchers tested whether routine ECGs could reveal more with far fewer labeled examples.
Columbia University will award the 2026 Louisa Gross Horwitz Prize to Adrian Bird and Huda Zoghbi for their pioneering work on epigenetic regulation in the nervous system and its role in human neurological disease, particularly Rett syndrome.
Clinicians often use a medical test called a 12-lead electrocardiogram (ECG) to diagnose heart problems, which uses electrodes placed on the chest and limbs to record the heart's electrical activity.
Jessica Thaxton, PhD, MsCR, associate professor in the Department of Cell Biology and Physiology at the UNC School of Medicine and co-leader of the Cancer Cell Biology Research Program at UNC Lineberger Comprehensive Cancer Center, has been awarded a prestigious $700,000 grant from the Mathers Foundation to support research into the role of the endoplasmic reticulum in T-cell metabolism and cancer development.
Functional coronary angiography significantly reduced cardiovascular events and improved safety compared with conventional angiography in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease.
A University of Maryland School of Medicine (UMSOM) stroke rehabilitation specialist helped develop new recommendations for studying molecular biomarkers associated with recovery from stroke.
In their quest to understand how cancers take root, grow and spread, scientists have for the past half-century explored the genetic aberrations and microenvironmental peculiarities of tumors and their constituent cells.
Researchers have discovered that SGLT2 inhibitors, a class of drugs originally developed to treat diabetes and now widely used for heart failure, work by activating a key enzyme that helps heart cells produce and use energy more efficiently.
A diet that severely limits carbohydrates but is high in fat has the greatest health benefits for people with obesity compared to a Mediterranean diet or a low-fat diet, according to a clinical trial publishing August 27 in the Cell Press journal Cell Metabolism.
Chronic kidney disease (CKD) is a major health burden affecting approximately one in ten adults globally. Even with improved treatments, many patients continue to have worsening loss of kidney function, resulting in the need for dialysis or transplantation.
A new study has identified why many men struggle with weight loss, finding that traditional diet programmes are often perceived as too restrictive and primarily aimed at women.
Do you ever feel like sometimes you can master a new dance step almost immediately, while other times you struggle to nail it despite repeated practice? This might be due to skill or effort, but also to something less obvious: whether the brain is in a state that allows learning to take hold.
Natural wild-derived microbiota protected mice against diet-induced obesity across sexes, genetic backgrounds, and age by increasing energy expenditure and promoting a thermogenic program in brown adipose tissue. The effect depended on the immune system’s initial encounter with the microbiota and required CCR2-associated myeloid activity, revealing a long-lasting microbiota-immune-brown fat pathway.
Approximately 3 million people in the United States are living with a condition called heart failure with preserved ejection fraction, or HFpEF.
COVID-19 can leave behind fatigue, breathing difficulties and neurological symptoms that persist long after the initial infection.
All living things have a fleet of tiny copy machines that turn instructions from DNA into RNA, the molecules responsible for helping build proteins that keep organisms alive.
Liver disease often progresses silently until it has become a serious condition. Researchers at The University of Toledo may have found a way to identify one of its earliest warning signs before symptoms appear.
Scientists have discovered that a key molecule released during exercise strengthens muscles, improves exercise performance and could be a therapeutic treatment for muscle damage caused by type 2 diabetes.
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