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Insilico Medicine reaches preclinical milestone in MASH drug discovery

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, recently achieved preclinical milestone in its collaboration with Therasid Bioscience, a South Korean based biotechnology company focuses on developing innovative first-in-class drugs for treatment for metabolic dysfunction-associated steatohepatitis (MASH).

25 Feb 2025

Vitamin E significantly improves liver health in MASH patients, new study finds

A 96-week clinical trial found that 300 mg of Vitamin E significantly improved liver histology and reduced inflammation in patients with MASH, with no major safety concerns reported.

19 Feb 2025

Natural supplement shows promise in treating heart disease

Heart transplant is a scary and serious surgery with high cost, but for patients with heart failure it can be the only option for cure.

13 Feb 2025

Could a common sugar in processed foods be fueling childhood liver disease?

Researchers found that high fructose intake, especially from processed foods, is linked to metabolic dysfunction-associated steatotic liver disease (MASLD) in children with obesity, with potential misreporting of sugary food sources.

12 Feb 2025

Single heat stroke exposure triggers long-term health risks and metabolic vulnerabilities

The study links exertional heat stroke to chronic disorders, revealing impacts on body mass regulation and heart health, especially in high-fat diet scenarios.

3 Feb 2025

Traffic-related air pollution may raise the risk of metabolic-associated fatty liver disease

Long-term exposure to low levels of traffic-related air pollution harms the liver and may raise the risk of metabolic-associated fatty liver disease, a new study in mice suggests.

31 Jan 2025

GLP-1RA initiation linked to new thyroid cancer diagnoses

Researchers investigate the risk of incident thyroid cancer among patients treated with glucagon-like peptide-1 receptor agonists.

28 Jan 2025

Understanding the mechanisms behind alcohol-associated liver disease

A newly published review in eGastroenterology compiles recent research on alcohol-associated liver disease (ALD), offering an overview of its pathogenesis and efforts to better understand this condition.

19 Dec 2024

The role of phytochemicals in combating metabolic diseases

This editorial reviews the impact of phytochemicals on metabolic diseases, emphasizing their potential in reducing inflammation and improving health outcomes.

19 Dec 2024

Dual screening for liver fibrosis and retinopathy in type 2 diabetes

Retina scanning with vibration-controlled transient elastography could predict metabolic dysfunction-associated steatotic liver disease.

17 Dec 2024

Revolutionizing MASLD treatment with GLP-1 receptor agonists

Researchers explore the therapeutic potential and clinical insights of GP1-RAs in the management of metabolic dysfunction-associated steatotic liver disease.

16 Dec 2024

Tea, apples, and chocolate proven to support liver health

A flavonoid-rich diet, including apples, tea, and dark chocolate, significantly lowers the risk of non-alcoholic fatty liver disease (NAFLD) and improves liver health biomarkers. These findings highlight the potential of dietary flavonoids in combating liver fat accumulation and inflammation.

9 Dec 2024

Two new subtypes of MASH revealed with different risks and outcomes

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), impacts roughly 30% of the global adult population.

9 Dec 2024

Can fasting improve diabetes outcomes? Ramadan offers insights

A study during Ramadan shows intermittent fasting improves liver health, gut microbiota richness, and metabolic markers in T2DM patients. However, benefits fade quickly after fasting ends, highlighting the need for sustained interventions.

27 Nov 2024

How alcohol impacts male health

This research explores how alcohol consumption disrupts metabolism, damages the liver, and impairs male reproductive health, emphasizing the complex mechanisms and public health implications.

18 Nov 2024

HMGB1 as a key mediator in liver disease pathogenesis

Liver diseases, both acute and chronic, continue to pose significant clinical challenges due to high morbidity and mortality rates.

8 Nov 2024

Exploring the protective effects of HSD17B13 in hepatic steatosis

Chronic liver disease (CLD) is a growing global health challenge, accounting for millions of deaths each year. Its major contributors include metabolic dysfunction-associated steatohepatitis (MASH), alcoholic liver disease (ALD), and hepatitis C virus infection.

8 Nov 2024