Transcription Factors News and Research

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PTGES3 emerges as key regulator of androgen receptor in prostate cancer

A poorly characterized protein, historically thought to be a chaperone or enzyme, may actually be a key player in prostate cancer.

5 Nov 2025

Thiostrepton suppresses rhabdomyosarcoma progression by targeting the PI3K–AKT pathway

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

30 Oct 2025

Study finds evidence for repurposing thiostrepton as an anti-rhabdomyosarcoma drug

Rhabdomyosarcoma (RMS) accounts for up to 10% of childhood cancers and nearly half of pediatric soft tissue sarcomas.

27 Oct 2025

Multidimensional regulation of stem cell fate by the cohesin complex

Conventional studies on stem cell fates are primarily focused on transcription factors, with the limited consideration for 3D genome architecture.

10 Oct 2025

Study shows how early-life epigenetic 'memory' can influence adult brain inflammation

Why do some people remain healthy through childhood yet become more vulnerable to brain disorders such as dementia later in life? A KAIST (President Kwang Hyung Lee) -led team has uncovered a key part of the answer: a developmental 'switch' in astrocytes—the brain's most abundant support cells that shapes how strongly the brain's immune system reacts in adulthood.

25 Sep 2025

Loss of key Y chromosome gene causes infertility in male mice

In a new study conducted at the University of Hawaiʻi at Mānoa, researchers from the John A. Burns School of Medicine (JABSOM) have shown that the loss of a key male fertility gene leads to infertility and changes expression of hundreds of other important genes.

17 Sep 2025

Study reveals how centenarians preserve youthful immune defenses

Researchers mapped immune cells from centenarians, their offspring, and younger controls across three cohorts using multi-omics single-cell profiling. They found that centenarians retain leaner helper pools but have enhanced cytotoxic and NK cell programs, along with reinforced NK–T communication networks.

15 Sep 2025

Researchers reveal why no level of air pollution is safe for respiratory health

A review in the Journal of Clinical Investigation shows how particulate matter damages the lungs through oxidative stress, inflammation, and immune disruption. It links air pollution to asthma, COPD, lung cancer, infections, and millions of premature deaths, with no safe exposure threshold.

9 Sep 2025

Unlocking the secrets of oral bacteria to fight tooth decay

If Wenjun Zhang has her way, no one will ever have to brush or floss again.

5 Sep 2025

New insights into pathogenic T cells offer hope for Crohn's disease treatment

The research group led by Drs. Mitsuru Arase, Mari Murakami, and Prof. Kiyoshi Takeda (Graduate School of Medicine/ Immunology Frontier Research Center at The University of Osaka) revealed that transcription factors RUNX2 and BHLHE40 play crucial roles in inducing T cells involved in Crohn's disease.

4 Sep 2025

Transcription factors SP5 and SP8 regulate primary cilia formation in embryos

Some might say it looks like a finger. Others might see a worm. Scientists in the field often liken it to an antenna.

29 Aug 2025

Researchers identify genetic toolkit to reprogram cells into immune sentinels

An international team led by researchers at Lund University in Sweden has identified the molecular tools needed to reprogram ordinary cells into specialized immune cells.

29 Aug 2025

SOX2 drives progression and therapy resistance in advanced prostate cancer

Prostate cancer remains a global health challenge, ranking as the second most common malignancy among men.

22 Aug 2025

Can turmeric/curcumin help with weight control in diabetes?

Curcumin/turmeric supplements modestly reduced body weight, waist size, fat mass, and hip circumference in people with type 2 diabetes. Benefits were also seen in prediabetic individuals, especially with longer use and high-absorption formulations.

18 Aug 2025

Systems biology identifies sentinel biomarkers bridging ankylosing spondylitis and myocardial infarction

Ankylosing spondylitis (AS) is increasingly recognized as an independent risk factor for premature myocardial infarction (MI), yet the molecular bridge linking chronic axial inflammation to acute coronary events remains poorly mapped.

14 Aug 2025

How circadian biology shapes intestinal regeneration and health

The interplay between the circadian clock, intestinal stem cell niche, and epithelial cell fate is shaping our understanding of how gut homeostasis and cellular regeneration are regulated.

14 Aug 2025

RSPO2 gene identified as key driver in metastatic prostate cancer

A new research paper was published in Volume 16 of Oncotarget on July 25, 2025, titled "Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer."

11 Aug 2025

New insights into how MYOD controls muscle repair and regeneration

For more than 30 years, scientists have studied how the myogenic determination gene number 1 (MYOD) protein binds DNA to modify the gene expression of muscle stem cells.

8 Aug 2025

NR2F1 drives fibrotic cataract formation through activation of STAT3

Cataracts remain one of the most prevalent and debilitating eye conditions, often requiring surgical intervention to restore sight. Yet even after surgery, many patients develop anterior subcapsular cataracts (ASC), characterized by fibrotic tissue growth beneath the lens capsule.

29 Jul 2025

Targeting tumor cell stemness may hold the key to treating colon cancer more effectively

Colon cancer remains a major global health concern, ranking third among the most diagnosed cancers and leading causes of cancer-related death worldwide.

22 Jul 2025