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Metformin’s blood sugar control starts in the brain, not just the liver, study finds

Low, clinically relevant doses of metformin lower blood glucose by inhibiting the Rap1 protein in specific neurons of the hypothalamus, revealing a brain-first mechanism. This action is essential for metformin’s effect at therapeutic doses and highlights new directions for diabetes treatment.

3 Aug 2025

AI spots hidden diabetes risk even when test results look normal

Researchers used continuous glucose monitoring and multimodal data from over 3,000 people to reveal hidden patterns in glucose spikes across normoglycemia, prediabetes, and type 2 diabetes. Their AI-driven model exposed high individual variability and offers a personalized path for early detection and prevention of diabetes.

3 Aug 2025

New study shows brain's role in diabetic ketoacidosis

More than a decade ago, researchers found that an acute complication of type 1 diabetes, diabetic ketoacidosis (DKA), can be resolved with the hormone leptin, even in the absence of insulin.

1 Aug 2025

The vicious circle of aging and metabolic dysfunction-associated steatotic liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: senescence of liver cells accelerates fat accumulation, inflammation and fibrosis, while chronic steatosis in turn hastens hepatic decline.

1 Aug 2025

New research reveals why fiber-rich diets fuel you better than refined foods

This study quantifies how much energy the human body harvests from gut microbial fermentation of dietary fiber, integrating bacterial physiology, diet, and metagenomic data. Results reveal that dietary fiber, not microbiome composition, mainly determines the amount of short-chain fatty acids absorbed, impacting daily energy and metabolic health.

31 Jul 2025

Saliva testing offers a non-invasive way to detect early metabolic risk

Measuring elevated levels of insulin in blood, called hyperinsulinemia, is a proven way to measure metabolic health and can show risk of developing future health concerns, including Type 2 diabetes, obesity and heart disease.

31 Jul 2025

Metformin lowers blood sugar by acting on brain pathways

Although metformin has been the go-to medication to manage type 2 diabetes for more than 60 years, researchers still do not have a complete picture of how it works.

31 Jul 2025

Brisk walking for just 15 minutes a day cuts death risk in low-income adults, study shows

Fast walking for as little as 15 minutes per day was linked to a nearly 20% reduction in mortality among predominantly Black and low-income American adults. Slow walking showed minimal benefit, but prolonged slow walking reduced the risk of death from ischemic heart disease.

30 Jul 2025

New high-selectivity nanozyme enables rapid and visible disease diagnostics

To enable early diagnosis of acute illnesses and effective management of chronic conditions, point-of-care testing (POCT) technology—diagnostics conducted near the patient—is drawing global attention.

30 Jul 2025

Intratumoral microbial metabolites shape the tumor microenvironment and impact immunotherapy

The tumor microenvironment (TME) represents a highly complex system that encompasses cellular components (such as cancer cells, stromal cells, and immune cells) and non-cellular components (such as blood vessels and signaling molecules).

30 Jul 2025

Canadian scientists trap gut microbe fuel to improve blood sugar and liver health

A team of Canadian scientists has discovered a surprising new way to improve blood sugar levels and reduce liver damage: by trapping a little-known fuel made by gut bacteria before they wreak havoc on the body.

30 Jul 2025

Analysis shows low pre-pregnancy glucose increases risk of preterm birth

An analysis of data from more than 4.7 million Chinese women showed that those who had low blood sugar levels prior to conception were more likely to have certain adverse pregnancy outcomes-such as their baby being born preterm or with low birth weight.

30 Jul 2025

Vanderbilt team explores functional β-cell enhancement for diabetes

If it has seemed like more people you know are developing diabetes, you are right. The diabetes epidemic is not called that for nothing: According to the American Diabetes Association, over 10 percent of the U.S. population-approximately 38.4 million people-had diabetes in 2021, and 1.2 million more people get diagnosed each year.

30 Jul 2025

Gut microbial metabolites restore hormone-producing cells in obesity

New research from scientists at the Marshall University Joan C. Edwards School of Medicine reveals that certain gut microbial byproducts may hold promise as a novel therapy for obesity-associated metabolic complications by restoring critical hormone-producing cells in the intestine.

29 Jul 2025

American Heart Association expands Cardiovascular-Kidney-Metabolic Health Initiative to 15 regions

People in 15 regions across the U.S. will soon benefit from the American Heart Association's Cardiovascular-Kidney-Metabolic Health Initiative™, designed to improve treatment of the interconnected conditions that lead to heart disease and stroke.

28 Jul 2025

UK self-tests overstate accuracy and pose usability risks

Analysis of UK self-tests reveals critical flaws in accuracy claims, highlighting risks and the need for enhanced regulatory standards for consumer safety.

28 Jul 2025

Which GLP-1 meds have the most side effects? Study of 60,000 Facebook posts gives answers

Researchers analyzed nearly 60,000 public Facebook posts to identify real-world adverse events linked to GLP-1 receptor agonist (GLP-1 RA) medications. Gastrointestinal symptoms were most common, while mental health concerns and tirzepatide-specific side effects were also flagged.

28 Jul 2025

New study shows potent effects of desert berry extract (NRK-C)

The global diabetes epidemic continues its relentless march, with projections suggesting 750 million sufferers by 2045. While current medications help control symptoms, they often come with undesirable side effects and don't address the root causes of metabolic dysfunction. The search for better solutions has turned scientists toward natural drugs, where traditional remedies may hold untapped potential.

26 Jul 2025

Creatine may enhance neuroprotection through energy pathways

Creatine supplementation may improve cognitive performance and mood, offering insights into its role in muscle-brain interactions and overall health.

25 Jul 2025

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

AMP-activated protein kinase (AMPK) plays a central role in maintaining energy balance in cells, especially under energy stress.

24 Jul 2025

Glucose News and Research

Metformin’s blood sugar control starts in the brain, not just the liver, study finds

AI spots hidden diabetes risk even when test results look normal

New study shows brain's role in diabetic ketoacidosis

The vicious circle of aging and metabolic dysfunction-associated steatotic liver disease

New research reveals why fiber-rich diets fuel you better than refined foods

Saliva testing offers a non-invasive way to detect early metabolic risk

Metformin lowers blood sugar by acting on brain pathways

Brisk walking for just 15 minutes a day cuts death risk in low-income adults, study shows

New high-selectivity nanozyme enables rapid and visible disease diagnostics

Intratumoral microbial metabolites shape the tumor microenvironment and impact immunotherapy

Canadian scientists trap gut microbe fuel to improve blood sugar and liver health

Analysis shows low pre-pregnancy glucose increases risk of preterm birth

Vanderbilt team explores functional β-cell enhancement for diabetes

Gut microbial metabolites restore hormone-producing cells in obesity

American Heart Association expands Cardiovascular-Kidney-Metabolic Health Initiative to 15 regions

UK self-tests overstate accuracy and pose usability risks

Which GLP-1 meds have the most side effects? Study of 60,000 Facebook posts gives answers

New study shows potent effects of desert berry extract (NRK-C)

Creatine may enhance neuroprotection through energy pathways

New redox-sensitive pathway reveals how cells activate AMPK in response to metabolic stress

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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