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Improving gene therapy safety with human kidney organoids

Ryuji Morizane, MD, PhD, of the Department of Medicine at Massachusetts General Hospital, is the senior/corresponding author of a new paper published in Signal Transduction and Targeted Therapy, "AAV for gene therapy drives a nephrotoxic response via NFκB in kidney organoids."

19 Aug 2025

Aggressive blood pressure management offers greater health benefits

Research led by investigators at Mass General Brigham suggests that the health benefits of more aggressive blood pressure control outweigh concerns about overtreating people with high blood pressure readings. Results of the simulation study are published in Annals of Internal Medicine.

19 Aug 2025

New nanoparticle drug delivery system targets the spleen for precise lupus treatment

With a $1 million Impact Award from the U.S. Department of Defense, Tianfu Wu, a University of Houston biomedical engineer, is developing a method to send medication directly to the spleen where certain immune cells cause the disease known as lupus, or Systemic Lupus Erythematosus.

18 Aug 2025

New nanoparticle system uses ultrasound to precisely deliver drugs

The trouble with many drugs is that they go where they shouldn't, producing unwanted side effects. Psychiatric drugs might cause dissociation, painkillers can induce nausea and chemotherapy often damages healthy cells.

18 Aug 2025

Targeting mitochondrial biogenesis to improve outcomes in acute kidney injury

Acute kidney injury (AKI) remains a significant global health challenge, with high mortality rates and the potential for progression to chronic kidney disease.

18 Aug 2025

Scientists urge shift in medicine to target the biology of aging

The most recent issue of Journal of the American Medical Association includes a landmark review highlighting innovative strategies to slow the biological aging process, an emerging approach with significant potential to prevent or delay multiple chronic diseases at once, one of the most pressing challenges in modern medicine today.

18 Aug 2025

New therapies for acute kidney injury show promise

Acute kidney injury (AKI) is a severe renal disorder affecting approximately 10%-15% of hospitalized patients and up to 50% in intensive care units (ICUs). Its pathogenesis involves complex inflammatory regulatory mechanisms. As core components of the cytokine network, interleukins (ILs) exert pleiotropic effects in AKI development, extensively participating in inflammation, fibrosis, tissue injury repair, and remote organ damage.

18 Aug 2025

Genetically-engineered immune cells show promise for preventing organ rejection

A Medical University of South Carolina team reports in Frontiers in Immunology that it has engineered a new type of genetically modified immune cell that can precisely target and neutralize antibody-producing cells complicit in organ rejection.

17 Aug 2025

Trial finds no cardiovascular benefit and higher safety risks with spironolactone in dialysis patients

A large international study has found that spironolactone, a medication for high blood pressure and heart failure, does not reduce the risk of heart-related death or hospitalizations in people with kidney failure receiving dialysis, despite earlier smaller studies suggesting benefit.

17 Aug 2025

International experts recommend broader use of cardioprotective diabetes drugs

SGLT-2 inhibitor and GLP-1 receptor agonist drugs should be used in all or almost all adults with type 2 diabetes at higher risk of cardiovascular and kidney complications, and in the majority of adults at moderate risk of complications, say a panel of international experts in The BMJ today.

17 Aug 2025

New 2025 guidelines focus on early intervention and lifestyle to manage high blood pressure

Preventing and managing high blood pressure with healthy lifestyle behaviors, such as following a heart-healthy diet including reducing salt intake, staying physically active, maintaining a healthy weight and managing stress—combined with early treatment with medication to lower blood pressure if necessary—are recommended to reduce the risk of heart attack, stroke, heart failure, kidney disease, cognitive decline and dementia, according to a new clinical guideline published today in the American Heart Association's peer-reviewed journals Circulation and Hypertension, and in JACC, the flagship journal of the American College of Cardiology.

14 Aug 2025

PFAS exposure increases risk of weight regain after adolescent bariatric surgery

Adolescents who undergo bariatric surgery face a higher risk of weight regain, which can undermine treatment success and long-term health, if they have elevated blood levels of per- and polyfluoroalkyl substances (PFAS) prior to the procedure, according to new USC research.

14 Aug 2025

New drug discovery platform aims to deliver first-in-class therapies

65LAB has awarded US$1.5 million (approx. S$1.9 million) to Professor Enrico Petretto to advance a breakthrough drug discovery platform developed at Duke-NUS Medical School. The project aims to deliver first-in-class antifibrotic therapies for lung and kidney diseases-conditions that currently have no effective treatment.

14 Aug 2025

NYU Langone Hospital—Suffolk performs first robotic cancer surgeries

Continuing its transformation since joining NYU Langone Health, the operative team at NYU Langone Hospital—Suffolk recently performed four complex robotic surgeries that had never been offered at the facility before, three of which successfully removed cancerous tumors from patients.

13 Aug 2025

New research explores foot positioning to treat knee osteoarthritis

Gait analysis and pain measures show that subtly adjusting the angle of the foot during walking may reduce knee pain caused by osteoarthritis. This approach may also slow progression of the condition, an uncurable disease in which the cartilage cushion inside a joint breaks down.

13 Aug 2025

Long COVID linked to lasting financial hardship and work disruption

While the economic impact of the COVID-19 pandemic continues to be widely studied and debated, the financial toll of the COVID-19 pandemic for individual patients is less understood.

12 Aug 2025

Study identifies biomarkers that could help predict and manage chronic kidney disease

Biomarkers that could help predict and manage chronic kidney disease (CKD) have been identified in a new study led by the University of Surrey.

12 Aug 2025

3D-printed kidney tumors offer a new tool in the fight against renal cancer

Scientists at Tsinghua University have developed a method to grow kidney tumors in the lab using cells from real patients, offering a potential new tool in the fight against renal cancer.

12 Aug 2025

New research highlights combined impact of genes and lifestyle on dilated cardiomyopathy

An international team, led by scientists from the Victor Chang Cardiac Research Institute has studied around 3000 people affected by the heart disease dilated cardiomyopathy (DCM) – a driver of heart failure and sudden cardiac arrest.

12 Aug 2025

Fifteen-year study shows major gains in diabetes technology use and patient outcomes

A new study led by researchers at the Johns Hopkins Bloomberg School of Public Health found big increases in the use of continuous glucose monitoring and insulin delivery devices by children and adults with type 1 diabetes over a 15-year period, with corresponding jumps in optimal blood-sugar control.

11 Aug 2025