Clinical Trial News and Research

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New analysis reveals fundamental flaws in widely used measures of biological aging

A landmark review published today in Genomic Psychiatry challenges researchers to fundamentally reconsider how the field measures and conceptualizes biological aging.

3 Dec 2025

Prehabilitation helps reduce disability after surgery in frail older adults

A large clinical trial published in JAMA Surgery shows that prehabilitation (also called prehab) can reduce disability after surgery in older adults with frailty, provided they are able to fully take part in the prehab program.

3 Dec 2025

Tai chi proves as effective as CBT for long-term insomnia relief

Researchers compare the efficacy of Tai chi with cognitive behavioral therapy for the treatment of chronic insomnia.

3 Dec 2025

SCAI and CRT launch partnership to expand innovation and training in interventional cardiology

The Society for Cardiovascular Angiography & Interventions (SCAI) and Cardiovascular Research Technologies (CRT) today announce a new collaboration to elevate the field of interventional cardiology through shared education programming, legislative activities, and future research initiatives.

2 Dec 2025

Shingles vaccine may benefit individuals already diagnosed with dementia, new study finds

An unusual public health policy in Wales may have produced the strongest evidence yet that a vaccine can reduce the risk of dementia.

2 Dec 2025

Expert guidelines for fungal endophthalmitis in the Asia-Pacific region

Fungal eye infections affect millions globally, with an especially high incidence in South and Southeast Asia.

1 Dec 2025

Blocking a ‘gerozyme’ reverses cartilage loss in mice

An injection that blocks the activity of a protein involved in aging reverses naturally occurring cartilage loss in the knee joints of old mice, a Stanford Medicine-led study has found.

28 Nov 2025

Breakthrough immunotherapy approved for treatment of adults with aggressive blood cancer

Adult patients with an aggressive form of leukemia will be able to receive a breakthrough immunotherapy, which was invented by UCL researchers, on the NHS within weeks following approval for use by the National Institute for Health and Care Excellence (NICE).

27 Nov 2025

Eli Lilly’s Adverum move: The future of ocular gene therapy at the 4th Ophthalmic Drug Delivery Summit

The race to develop safer, longer lasting, and less invasive treatments is accelerating, and at the heart of that challenge lies drug delivery.

From Hanson Wade Group - 4th Ophthalmic Drug Delivery Summit 26 Nov 2025

Experimental drug engasertib shows promise for treating inherited bleeding disorder

Hereditary hemorrhagic telangiectasia (HHT) is the second most common inherited bleeding disorder worldwide, affecting 1 in 3,800 persons.

26 Nov 2025

Missing cancer gene may boost response to immunotherapy

For some patients with the most common type of lung cancer, known as lung adenocarcinoma, there's new hope.

26 Nov 2025

New 10-minute scan shows hidden cause of high blood pressure

A speedy new scan could improve how millions of people with high blood pressure are treated, suggests a new study led by UCL (University College London) researchers.

26 Nov 2025

Monthly biologic injection improves severe asthma control and reduces steroid use

A monthly injection has helped 90% of severe asthma patients reduce daily steroid tablets, which are associated with long-term side effects.

26 Nov 2025

AI tools can ease documentation burden and reduce physician burnout

Artificial intelligence (AI) tools designed to automatically document patient visits show promise in reducing the time physicians spend on paperwork and may improve their work experience, according to a new randomized clinical trial conducted at UCLA Health.

26 Nov 2025

SISAQOL-IMI provides guidance for implementing patient-reported outcomes in cancer clinical trials

The SISAQOL-IMI consortium, co-led by the European Organisation for Research and Treatment of Cancer (EORTC) and Boehringer Ingelheim (BI), just announced the publication of its pivotal paper in The Lancet Oncology outlining how its recommendations for patient-reported outcomes (PROs) in cancer clinical trials were developed.

26 Nov 2025

Metformin fails to improve insulin resistance in type 1 diabetes

Metformin treatment in type 1 diabetes lowers insulin dosage but does not improve insulin resistance, highlighting its complex role in diabetes management.

26 Nov 2025

Blocking immune cell signals reduces scar tissue formation in wounds

Researchers at the University of Arizona uncovered a previously unknown population of circulating immune cells that play a critical role in fibrosis, the buildup of scar tissue that can lead to organ failure and disfigurement.

25 Nov 2025

Zanidatamab shows durable and meaningful responses in HER2-positive biliary tract cancer

Zanidatamab, a bispecific HER2-targeted antibody, delivered clinically meaningful and durable responses for patients with HER2-positive biliary tract cancer (BTC), according to final results from the HERIZON-BTC-01 clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

25 Nov 2025

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Patients with the deadliest form of brain cancer, glioblastoma, who received MRI-guided focused ultrasound with standard-of-care chemotherapy had a nearly 40 percent increase in overall survival in a landmark trial of 34 patients led by University of Maryland School of Medicine (UMSOM) researchers.

24 Nov 2025

Study reveals metabolic benefits of reducing ultra-processed foods in older adults

A controlled feeding study out of South Dakota State University shows that older adults who ate fewer ultra-processed foods naturally consumed fewer calories, lost weight and abdominal fat, and showed improvements in insulin, nutrient-sensing hormones, and inflammation.

24 Nov 2025

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Clinical Trial News and Research

New analysis reveals fundamental flaws in widely used measures of biological aging

Prehabilitation helps reduce disability after surgery in frail older adults

Tai chi proves as effective as CBT for long-term insomnia relief

SCAI and CRT launch partnership to expand innovation and training in interventional cardiology

Shingles vaccine may benefit individuals already diagnosed with dementia, new study finds

Expert guidelines for fungal endophthalmitis in the Asia-Pacific region

Blocking a ‘gerozyme’ reverses cartilage loss in mice

Breakthrough immunotherapy approved for treatment of adults with aggressive blood cancer

Eli Lilly’s Adverum move: The future of ocular gene therapy at the 4th Ophthalmic Drug Delivery Summit

Experimental drug engasertib shows promise for treating inherited bleeding disorder

Missing cancer gene may boost response to immunotherapy

New 10-minute scan shows hidden cause of high blood pressure

Monthly biologic injection improves severe asthma control and reduces steroid use

AI tools can ease documentation burden and reduce physician burnout

SISAQOL-IMI provides guidance for implementing patient-reported outcomes in cancer clinical trials

Metformin fails to improve insulin resistance in type 1 diabetes

Blocking immune cell signals reduces scar tissue formation in wounds

Zanidatamab shows durable and meaningful responses in HER2-positive biliary tract cancer

Focused ultrasound combined with chemotherapy improves survival in glioblastoma patients

Study reveals metabolic benefits of reducing ultra-processed foods in older adults

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