MicroRNA News and Research

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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.

EMD Serono announces recipients of company's inaugural Grant for Multiple Sclerosis Innovation

EMD Serono, Inc., a subsidiary of Merck KGaA, Darmstadt, Germany, announced today on the occasion of the 29th European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), the recipients of the company's inaugural Grant for Multiple Sclerosis Innovation (GMSI).

7 Oct 2013

New agreement to expand scope of research project to evaluate MCT-485 for primary liver cancer

MultiCell Technologies, Inc. is pleased to announce the signing of a new sponsored research agreement with Anand Ghanekar, M.D., Ph.D, of the University Health Network's Toronto General Hospital expanding the scope of the research project to evaluate MCT-485 in animal models for the treatment of primary liver cancer.

2 Oct 2013

miR-31 in primary tumor cells predicts lymph node metastasis in NSCLC patients

Determining whether a patient's lung cancer has spread to nearby lymph nodes is critical for identifying the most effective therapy, but it usually requires surgery. A new study suggests, however, that measuring levels of a particular molecule in a sample of tumor tissue might accurately answer the question.

25 Sep 2013

EpimiRNA Consortium concentrates on developing novel mRNA-based therapeutics to prevent epilepsy

Over 50 million people across the world suffer from epilepsy, making it the most common serious neurological disorder for which there is no cure. The causes for epilepsy are insufficiently understood with currently available treatments being sub-optimal and with a significant proportion of patients not responding

19 Sep 2013

University of Chicago researchers awarded NIH grant to develop novel multiple sclerosis treatment

Researchers from the University of Chicago have been awarded a five-year, $1.5 million grant from the National Institutes of Health to develop stimulated dendritic cell-derived exosomes that show remarkable promise as a treatment for multiple sclerosis and other neurological diseases involving loss of myelin, the insulation around nerve fibers.

18 Sep 2013

microRNA-486 found to be potent tumor-suppressor molecule in lung cancer

New research shows that microRNA-486 is a potent tumor-suppressor molecule in lung cancer, and that the it helps regulate the proliferation and migration of lung-cancer cells, and the induction of programmed cell death, or apoptosis, in those cells.

17 Sep 2013

Elevated miR-200 boosts survival of lung, ovarian, renal, triple-negative breast cancer patients

A family of microRNAs (miR-200) blocks cancer progression and metastasis by stifling a tumor's ability to weave new blood vessels to support itself, researchers at The University of Texas MD Anderson Cancer Center report today in Nature Communications.

12 Sep 2013

ddPCR technology can be used to reproducibly quantify microRNA in plasma

A study published online in Nature Methods today demonstrated that Droplet Digital PCR (ddPCR-) technology can be used to precisely and reproducibly quantify microRNA (miRNA) in plasma and serum across different days, paving the way for further development of miRNA and other nucleic acids as circulating biomarkers.

2 Sep 2013

Jia Shen receives 2013 Jess Hay Chancellor's Graduate Student Research Fellowship

Jia Shen, a student at The University of Texas Graduate School of Biomedical Sciences at Houston, is a recipient of a 2013 Jess Hay Chancellor's Graduate Student Research Fellowship. This award is given to two students per year across the entire University of Texas System, which is comprised of nine universities and six health institutions.

29 Aug 2013

UAB study points to protein pathway that could lead to new treatments for diabetes

The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham study published online today in the journal Nature Medicine.

27 Aug 2013

Scientists Shed New Light On Malignant Pancreatic Cancer

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23 Aug 2013

Shire extends existing partnership with Santaris Pharma in rare genetic disease space

Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, today announced that its long term partner, Shire has extended the existing partnership in the rare genetic disease space.

23 Aug 2013

Scientists identify molecular mechanism that contributes to pancreatic cancer

New research led by scientists at The University of Texas Health Science Center at Houston (UTHealth) and Baylor College of Medicine could aid efforts to diagnose and treat one of the most lethal and hard-to-treat types of cancer.

23 Aug 2013

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, announced today that the U.S. Food & Drug Administration (FDA) has granted an Orphan Drug Designation to ALN-AT3 as a therapeutic for the treatment of hemophilia B.

17 Aug 2013

BIDMC cardiovascular research team receives $4M grant to identify mRNA biomarkers in heart disease

A cardiovascular research team from Beth Israel Deaconess Medical Center (BIDMC) and Brigham and Women's Hospital (BWH), led by BIDMC Principal Investigator Saumya Das, MD, PhD, has been awarded a $4 million Common Fund grant from the National Institutes of Health (NIH) as part of a newly formed program on Extracellular RNA Communication.

17 Aug 2013

German researchers discover miRNAs, which determine malignancy of urinary bladder cancers

German researchers have identified four biomarkers that correctly determine malignancy of urinary bladder cancers and contribute to the accurate prediction of patient outcomes. Their results are published in the September issue of The Journal of Molecular Diagnostics.

16 Aug 2013

Strategy that dismantles flu viral genome in human lung cells ensures safe research

A new strategy that dismantles a viral genome in human lung cells will ensure safe research on deadly strains of influenza, say researchers from the Icahn School of Medicine at Mount Sinai.

13 Aug 2013

Study: Immune-regulating molecules can trigger lymphomas

A small group of immune-regulating molecules, when overproduced even moderately, can trigger the blood cancers known as lymphomas, according to a new study led by scientists from The Scripps Research Institute (TSRI).

9 Aug 2013

Researchers identify mechanism responsible for loss of tumor-suppressor gene in soft-tissue sarcomas

Researchers have discovered a novel mechanism responsible for the loss of a critical tumor-suppressor gene in rhabdomyosarcoma and other soft-tissue sarcomas, rare cancers that strike mainly children and often respond poorly to treatment. Their cause is largely unknown.

8 Aug 2013

Obese fathers may pass their obesity to children and grandchildren

New research from the University of Adelaide shows that the sperm of obese fathers could increase the risk of both their children and their grandchildren to inherit obesity.

16 Jul 2013

MicroRNA News and Research

Further Reading

EMD Serono announces recipients of company's inaugural Grant for Multiple Sclerosis Innovation

New agreement to expand scope of research project to evaluate MCT-485 for primary liver cancer

miR-31 in primary tumor cells predicts lymph node metastasis in NSCLC patients

EpimiRNA Consortium concentrates on developing novel mRNA-based therapeutics to prevent epilepsy

University of Chicago researchers awarded NIH grant to develop novel multiple sclerosis treatment

microRNA-486 found to be potent tumor-suppressor molecule in lung cancer

Elevated miR-200 boosts survival of lung, ovarian, renal, triple-negative breast cancer patients

ddPCR technology can be used to reproducibly quantify microRNA in plasma

Jia Shen receives 2013 Jess Hay Chancellor's Graduate Student Research Fellowship

UAB study points to protein pathway that could lead to new treatments for diabetes

Scientists Shed New Light On Malignant Pancreatic Cancer

Shire extends existing partnership with Santaris Pharma in rare genetic disease space

Scientists identify molecular mechanism that contributes to pancreatic cancer

FDA grants Orphan Drug Designation to Alnylam ALN-AT3 for treatment of hemophilia B

BIDMC cardiovascular research team receives $4M grant to identify mRNA biomarkers in heart disease

German researchers discover miRNAs, which determine malignancy of urinary bladder cancers

Strategy that dismantles flu viral genome in human lung cells ensures safe research

Study: Immune-regulating molecules can trigger lymphomas

Researchers identify mechanism responsible for loss of tumor-suppressor gene in soft-tissue sarcomas

Obese fathers may pass their obesity to children and grandchildren

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