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Biogen begins ISIS-SOD1 Rx Phase 1/2 clinical study in patients with amyotrophic lateral sclerosis

Isis Pharmaceuticals, Inc. today announced that its partner, Biogen, has initiated a Phase 1/2 clinical study of ISIS-SOD1 Rx (BIIB067) in patients with amyotrophic lateral sclerosis (ALS).

11 Dec 2015

FDA grants Fast Track status to Cardiorentis' Ularitide for treatment of ADHF

Cardiorentis AG, a privately held biopharmaceutical company, today announced that the U.S. Food and Drug Administration has granted Fast Track status to Ularitide, an investigational therapy for the treatment of acute decompensated heart failure (ADHF).

11 Dec 2015

Cancer drug can neutralize toxic RNA that causes myotonic dystrophy

A group of researchers has shown for the first time in cells and in a mouse model that a drug used to treat cancer can neutralize the toxic RNA that causes the prolonged muscle contractions and other symptoms of myotonic dystrophy type 1, the most common form of adult-onset muscular dystrophy.

11 Dec 2015

Human heart can fully recover after massive damage

The scientists report the case of a newborn that had suffered a massive heart attack in the first hours of life. It was caused by a blockage in a vital coronary vessel. "The baby's heart was severely damaged. Astonishingly, the baby recovered very quickly," said Bernhard Haubner, a cardiologist and researcher, and his colleague, Johanna Schneider, in an article just published in the journal "Circulation Research".

10 Dec 2015

New artificial muscle imitates macroscopic movement of human muscles

The macroscopic movement of our muscles is caused by the collective movement of “biomolecular motors”. Scientists and engineers have long been trying to imitate this process.

10 Dec 2015

Study reveals pathogenetic role of miR-125a in pulmonary hypertension

Pulmonary hypertension is an umbrella term used for many conditions that all result in elevation of the pulmonary arterial pressure. Of interest, many of these completely different clinical and pathophysiological entities result in a final common pathway of vasoconstriction, micro thrombosis and vascular remodelling.

10 Dec 2015

Research examines ketone esters to combat hyperbaric oxygen toxicity in Navy divers

For the first time, ketone esters-oral supplements useful in epilepsy treatment-are being studied to fight seizures caused by hyperbaric oxygen toxicity, a life-threatening byproduct of breathing too much oxygen that impacts deep-water divers.

9 Dec 2015

Existing compound offers hope for slowing Huntington's disease progression

Currently, there is no treatment to halt the progression of Huntington's disease (HD), a fatal genetic disorder that slowly robs sufferers of their physical and mental abilities. Now, researchers at University of California, San Diego School of Medicine have discovered that an existing compound, previously tested for diabetes, offers hope for slowing HD and its symptoms.

8 Dec 2015

Researchers discover unique muscle fibers of upper airways often present in sleep apnea patients

Researchers at Umeå University in Sweden have discovered unique muscle fibers in the soft palate of the mouth in both infants and adults. The fibers seem to be present in greater number in snorers and sleep apnea patients.

8 Dec 2015

TSRI scientists use new drug discovery technique to identify anti-diabetes compound

Scientists from The Scripps Research Institute have deployed a powerful new drug discovery technique to identify an anti-diabetes compound with a novel mechanism of action.

8 Dec 2015

XARELTO reduces rates of major bleeding, recurrent blood clots in people with deep vein thrombosis

Janssen Pharmaceuticals, Inc. and its development partner, Bayer HealthCare, today announced the results from their real-world study XALIA showing that, in people with deep vein thrombosis (DVT), the rates of major bleeding and recurrent blood clots for XARELTO (rivaroxaban) in routine clinical practice were generally consistent with those observed in Phase 3 research.

7 Dec 2015

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

New research adds to a growing body of evidence that gene therapy, an experimental technique that involves correcting or replacing a person's mutated or malfunctioning genes, may improve health outcomes for patients with inherited bleeding and immune disorders as well as some forms of blood cancer.

7 Dec 2015

Preventable comorbidities common in cerebral palsy patients

Medical comorbidities are common in patients with cerebral palsy and may impact on their mobility, report researchers.

2 Dec 2015

Bacteriophage therapy: an alternative to antibiotics? An interview Professor Clokie

A phage is a virus that infects a bacterium. People often get very confused about what the difference is between a virus and a bacterium. A virus, like a bacterium, is also a microorganism, but unlike bacteria, it needs to have a host to be able to replicate and propagate.

2 Dec 2015

Advances in leadless pacing: an interview with Dr. Reddy

Pacemakers have been around for a very long time, they're great devices, critical for many people who have slow heartbeats. While they're very effective, they have some issues. There are two main aspects relating to these issues.

1 Dec 2015

Philips’ new MRI guided user interface simplifies scanning of patients with MR Conditional implants

Royal Philips today introduced ScanWise Implant, the industry's first MRI guided user interface and automatic scan parameter selection to help simplify the scanning of patients with MR Conditional implants, such as knee and hip replacements, spine implants and pacemakers, at the 2015 Radiological Society of North America Annual Meeting.

1 Dec 2015

Philips launches IntelliSpace Portal 8.0 platform for diagnosis and treatment of cancer

Strengthening its leadership in connected healthcare informatics, Royal Philips (NYSE: PHG, AEX: PHIA) today announced IntelliSpace Portal 8.0 , the latest edition of its advanced data sharing, analytics and visualization platform that helps radiologists detect, diagnose and follow-up on treatment of diseases.

1 Dec 2015

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

Researchers at the Translational Genomics Research Institute and Barrow Neurological Institute have for the first time identified genetic risk factors that are linked to stress-induced cardiomyopathy (SIC), a rare type of heart disease.

1 Dec 2015

UofL researchers discover mechanism involved in skeletal muscle repair

Researchers at the University of Louisville have discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies for diseases such as muscular dystrophy.

1 Dec 2015

Johns Hopkins researchers develop method to turn stem cells into retinal ganglion cells

Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, the type of nerve cells located within the retina that transmit visual signals from the eye to the brain. Death and dysfunction of these cells cause vision loss in conditions like glaucoma and multiple sclerosis.

1 Dec 2015

Muscle News and Research

Biogen begins ISIS-SOD1 Rx Phase 1/2 clinical study in patients with amyotrophic lateral sclerosis

FDA grants Fast Track status to Cardiorentis' Ularitide for treatment of ADHF

Cancer drug can neutralize toxic RNA that causes myotonic dystrophy

Human heart can fully recover after massive damage

New artificial muscle imitates macroscopic movement of human muscles

Study reveals pathogenetic role of miR-125a in pulmonary hypertension

Research examines ketone esters to combat hyperbaric oxygen toxicity in Navy divers

Existing compound offers hope for slowing Huntington's disease progression

Researchers discover unique muscle fibers of upper airways often present in sleep apnea patients

TSRI scientists use new drug discovery technique to identify anti-diabetes compound

XARELTO reduces rates of major bleeding, recurrent blood clots in people with deep vein thrombosis

Experimental gene therapy may improve health outcomes for patients with some forms of blood disorders

Preventable comorbidities common in cerebral palsy patients

Bacteriophage therapy: an alternative to antibiotics? An interview Professor Clokie

Advances in leadless pacing: an interview with Dr. Reddy

Philips’ new MRI guided user interface simplifies scanning of patients with MR Conditional implants

Philips launches IntelliSpace Portal 8.0 platform for diagnosis and treatment of cancer

TGen, Barrow researchers identify genetic risk factors linked to stress-induced cardiomyopathy

UofL researchers discover mechanism involved in skeletal muscle repair

Johns Hopkins researchers develop method to turn stem cells into retinal ganglion cells

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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