Respiratory News and Research

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Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

By applying a systems biology approach, a recent bioRxiv* preprint research paper by scientists from the Icahn School of Medicine at Mount Sinai in New York unveils interactions between the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) and p38 mitogen-activated protein kinase (MAPK) pathway responsible for regulating the expression of crucial inflammatory mediators in human lung epithelial cells.

23 Aug 2021

COVID booster shots might be needed in subgroup of HIV-positive individuals

The coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a global pandemic destroying lives and economies. COVID-19 is not curable, so vaccines are the only safeguard during this pandemic.

23 Aug 2021

Study: Awake prone positioning can reduce the need for mechanical ventilation in COVID-19 patients

A six country clinical study of more than 1,100 hospitalized COVID-19 patients who required high-flow nasal cannula oxygen therapy suggests that prone positioning (rotating patients with severe breathing issues so they are face down) soon after admission can significantly reduce the need for mechanical ventilation.

23 Aug 2021

Lipid-lowering drug TriCor dramatically cuts treatment time for severe COVID-19 patients

The SARS-CoV-2 virus has infected over 165 million people worldwide causing nearly 3.5 million deaths. Recent vaccination efforts have been hindered by multiple coronavirus variants that challenge current vaccines.

23 Aug 2021

SARS-CoV-2 alpha variant exhibits enhanced household transmission

In a recent study, the transmission rate of wildtype and the Alpha variant of SARS-CoV-2 through households is tracked.

23 Aug 2021

Broad-spectrum coronavirus neutralization amongst vaccinated SARS-CoV-1 survivors

The potency of neutralizing antibodies in individuals who have recovered from SARS-CoV and received the SARS-CoV-2 vaccine is evaluated.

23 Aug 2021

Exposure to wildfire smoke during pregnancy raises risk for preterm birth

Exposure to wildfire smoke during pregnancy increases the risk that a baby will be born too early, a new Stanford University study suggests.

23 Aug 2021

Expansion of seasonal betacoronavirus antibodies post-vaccination is associated with reduction in neutralization of the SARS-CoV-2 variants of concern

A new study determined the antibody response to SARS-CoV-2 and seasonal viruses induced by BNT162b2-Comirnaty vaccination in healthcare workers.

23 Aug 2021

How have SARS-CoV-2 variants of concern impacted national case fatality rates?

A new study aims to analyze the degree to which the new VoCs cause fluctuations in daily case fatality rates (CFR) across several countries.

23 Aug 2021

Does SARS-CoV-2 affect male fertility?

A recently published review describes the state of current knowledge regarding the impact of SARS-CoV-2 on the male reproductive system.

23 Aug 2021

The emergence and spread of the SARS-CoV-2 Lambda (B.1.621) variant

A new study details the genomic characteristics and descent of a SARS-CoV-2 variant of interest.

23 Aug 2021

New study identifies novel compound as promising pan-coronavirus drug candidate

A recent study describes a novel compound with frameshifting capability against MERS-CoV, inhibiting viral propagation within infected cells.

23 Aug 2021

New study reveals unique immune responses to SARS-CoV-2, Ebola and respiratory syncytial virus using B cell repertoire analysis

A new study has been published on the bioRxiv* preprint server, which takes a long-read repertoire amplification approach to better understand, compare and contrast B cell responses to emerging or endemic viruses.

23 Aug 2021

Study uses computational modeling of coronavirus spike proteins to examine dynamics responsible for immunogenicity and immune escape

A new study published on the bioRxiv* preprint server focused on the development of dynamic computational models for a large subset of S proteins of SARS-CoV, MERS-CoV, and SARS-CoV-2.

23 Aug 2021

Nanotechnology provides novel solutions against zoonotic viruses

Therefore, scientists functionalize nanoparticles to act against these pathogenic viruses in a clinical strategy. In a recent review published in the journal Microbial Pathogenesis, researchers look at the novel solutions against zoonotic viruses provided by nanotechnology.

23 Aug 2021

DeepSARS simultaneously detects and conducts genomic surveillance of SARS-CoV-2

A new study discusses the development of DeepSARS, a high-throughput platform for diagnostic detection and genomic surveillance of SARS-CoV-2.

23 Aug 2021

Study examines COVID vaccination in California state prisons

In a new retrospective cohort study, researchers determined the efficacy of mRNA vaccines against COVID-19 among incarcerated people in California.

22 Aug 2021

Therapeutic-dose anticoagulation benefits moderately ill COVID-19 patients

Moderately ill patients hospitalized with COVID-19 have better chances of survival if treated with therapeutic-dose anticoagulation, according to an international study involving 121 sites, including UT Southwestern Medical Center.

20 Aug 2021

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

New drugs are intended to help stop viral zoonoses - infections that jump from animals to humans. To study suitable inhibitors, Prof. Dr Christian Klein from the Institute of Pharmacy and Molecular Biotechnology of Heidelberg University is receiving funding in the amount of 450,000 euros from the Volkswagen Foundation.

20 Aug 2021

New antibody found to be highly protective against wide range of COVID-19 virus variants

The virus that causes COVID-19 today is not the same as the one that first sickened people way back in December 2019.

20 Aug 2021

Respiratory News and Research

Study pinpoints an enzyme with a significant impact on SARS-CoV-2 replication

COVID booster shots might be needed in subgroup of HIV-positive individuals

Study: Awake prone positioning can reduce the need for mechanical ventilation in COVID-19 patients

Lipid-lowering drug TriCor dramatically cuts treatment time for severe COVID-19 patients

SARS-CoV-2 alpha variant exhibits enhanced household transmission

Broad-spectrum coronavirus neutralization amongst vaccinated SARS-CoV-1 survivors

Exposure to wildfire smoke during pregnancy raises risk for preterm birth

Expansion of seasonal betacoronavirus antibodies post-vaccination is associated with reduction in neutralization of the SARS-CoV-2 variants of concern

How have SARS-CoV-2 variants of concern impacted national case fatality rates?

Does SARS-CoV-2 affect male fertility?

The emergence and spread of the SARS-CoV-2 Lambda (B.1.621) variant

New study identifies novel compound as promising pan-coronavirus drug candidate

New study reveals unique immune responses to SARS-CoV-2, Ebola and respiratory syncytial virus using B cell repertoire analysis

Study uses computational modeling of coronavirus spike proteins to examine dynamics responsible for immunogenicity and immune escape

Nanotechnology provides novel solutions against zoonotic viruses

DeepSARS simultaneously detects and conducts genomic surveillance of SARS-CoV-2

Study examines COVID vaccination in California state prisons

Therapeutic-dose anticoagulation benefits moderately ill COVID-19 patients

Heidelberg researchers focus on developing drugs against flavi- and coronaviruses

New antibody found to be highly protective against wide range of COVID-19 virus variants

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