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Discovery of gene that controls sugar production, implications for diabetes

Scientists in Sydney and Boston believe they may have identified a gene that controls abnormal production of sugar in the liver, a very troublesome problem for people with diabetes.

22 May 2009

Getting more from whole-transcript microarrays

The widely-used Affymetrix Whole-Transcript Gene 1.0 ST (sense target) microarray platform, normally used to assay gene expression, can also be utilized to interrogate exon-specific splicing. Research published today in the open access journal BMC Bioinformatics shows scientists how to monitor alternative splicing activity on a genome-wide scale, without investing in new exon microarray technologies.

22 May 2009

NIH to develop therapeutics for rare and neglected diseases

The National Institutes of Health is launching the first integrated, drug development pipeline to produce new treatments for rare and neglected diseases. The $24 million program jumpstarts a trans-NIH initiative called the Therapeutics for Rare and Neglected Diseases program, or TRND.

20 May 2009

New hope for warding off diabetes nerve loss

A common blood test for triglycerides - a well-known cardiovascular disease risk factor - may also for the first time allow doctors to predict which patients with diabetes are more likely to develop the serious, common complication of neuropathy.

18 May 2009

Snoring and sleep apnoea damage the brain

Australian researchers have found that the effects of sleep apnoea on the brain of a sleeping patient are far worse than previously thought.

17 May 2009

The end of the line for existing stem cell research?

Time is short for scientists to respond to the call for comments on the National Institutes of Health (NIH) proposed guidelines for the use of human embryonic stem (ES) cell lines and their eligibility for federal funds. On May 26, the window to provide feedback will close, and the drafted rules leave the possibility that funding for almost all existing cell lines will disappear.

15 May 2009

University of Liverpool awarded £2.2 million for genomics hub

The University of Liverpool has been awarded £2.2 million to establish a high-throughput genomic analysis hub for the North of England.

13 May 2009

Simple interventions could contain flu spread – focus on children

Although many have touted strategies from travel avoidance to Tamiflu to halt the spread of H1N1 flu or swine flu, a large body of evidence from the Cochrane Library suggests that concentrating on children's hygiene might be the best way to reduce the spread of respiratory illnesses.

12 May 2009

New guidelines on when to repeat bone mineral density tests for their patients

International clinical guidelines on the matter are hazy, with different practices followed in different countries. For a serious condition like osteoporosis, affecting millions, it is important to establish clear protocols.

12 May 2009

In retinal disease, sight may depend on second sites

If two people have the same genetic disease, why would one person go blind in childhood but the other later in life or not at all? For a group of genetic diseases - so-called ciliary diseases that include Bardet-Biedl syndrome, Meckel-Gruber syndrome, and Joubert syndrome - the answer lies in one gene that is already linked to two of these diseases and also seems to increase the risk of progressive blindness in patients with other ciliary diseases. The findings are published online this week at Nature Genetics.

12 May 2009

Nearly one-third of cancer studies report conflicts of interest

Nearly one-third of cancer research published in high-impact journals disclosed a conflict of interest, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.

12 May 2009

Probiotics may help fight obesity post pregnancy

One year after giving birth, women were less likely to have the most dangerous kind of obesity if they had been given probiotics from the first trimester of pregnancy, found new research that suggests manipulating the balance of bacteria in the gut may help fight obesity.

7 May 2009

IBM and University of Texas Medical Branch launch effort to find flu drug treatments

IBM and the University of Texas Medical Branch (UTMB) launched an effort using IBM's World Community Grid "virtual supercomputer" to allow laboratory tests on drug candidates for drug-resistant influenza strains and new strains, such as H1N1, in less than a month.

6 May 2009

New antidepressants might be no more effective than the best existing drugs

The reviews suggest that sertraline - sold under the brand name Zoloft since 1991- could be the best initial choice of antidepressant in people with acute major depression. The generic formulation produced the best balance of effectiveness, tolerability and purchase price, the authors say.

5 May 2009

Zinc supplementation can be ineffective in the treatment of diarrhea

Zinc supplementation can be ineffective in the treatment of diarrhea. A randomised controlled trial published in the open access journal BMC Medicine has shown that supplementation with either zinc or zinc and copper is no more effective than placebo.

5 May 2009

Social isolation the way to stop flu spreading

Australian researchers say isolation would slow down the spread of outbreaks of influenza.

3 May 2009

Many patients in intensive care are deficient in vitamin D

Australian researchers have discovered that many critically ill patients in intensive care are deficient in vitamin D.

30 Apr 2009

USA Today examines Specter's voting history, impact of moving to Democratic party

Health reform advocates believe Sen. Arlen Specter's (Pa.) recent switch to the Democratic Party improves the chances of passing a health care overhaul this year, USA Today reports.

30 Apr 2009

Breakthrough in understanding of how blood cells develop and divide

A West Australian research team has made the world-first discovery a 'pied piper' molecule within blood cells, called Liar, that leads other molecules into the nucleus of the cell, and could offer a key in treating prostate, breast and colon cancers as well as leukemia.

30 Apr 2009

Stem cell focus for inflammatory bowel disease wound healing

Scientists at The University of Nottingham are investigating whether stem cell markers could have a role to play in speeding up wound healing in patients suffering from inflammatory bowel disease (IBD).

30 Apr 2009