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Computational study identifies key areas of the SARS-CoV-2 genome prone to mutation

By retrieving 329,942 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) records from the GISAID database, researchers from a software company in Cambridge described genetic variability of SARS-CoV-2 in order to inform further studies. Their findings are currently available on the bioRxiv* preprint server while it undergoes peer review.

9 Aug 2021

Surfactant-coated nanoparticle applications in nanomedicine and food

A group of researchers critically review the use of surfactant-coated nanoparticles in the fields of nanomedicine and food nanotechnology.

8 Aug 2021

Long COVID may be due to persistent immune disturbances

A new study discusses abnormalities in the immune response following COVID-19 in samples collected from patients who have recovered from COVID-19.

8 Aug 2021

Study uncovers link between corticosteroid receptors and ciliary, neuroplasticity genes in the brain

Chronic stress is a well-known cause for mental health disorders. New research has moved a step forward in understanding how glucocorticoid hormones ('stress hormones') act upon the brain and what their function is.

6 Aug 2021

Education and employment experiences in early adulthood play a role in later life cardiovascular health

New research published today in the Journal of Epidemiology and Community Health has found that education and employment experiences in early adulthood contribute to cardiovascular health inequalities in later life, independent of occupation and family income in mid-adulthood.

6 Aug 2021

Research reveals a microRNA network as putative mediators of myocardial reductive stress

Last year, University of Alabama at Birmingham researchers reported that reductive stress - an imbalance in the normal oxidation/reduction homeostasis - caused pathological changes associated with heart failure in a mouse model.

6 Aug 2021

Researchers uncover new mitochondrial recycling pathway that may be linked to Parkinson’s disease

Scientists have long known that living cells are master recyclers, constantly breaking down old parts and building them back up into new molecular machines.

6 Aug 2021

Affinity maturation of SARS-CoV-2 antibodies make them more powerful and resistant to escape mutations

A new study in the journal Immunity shows in fascinating detail how antibodies elicited by this virus show affinity maturation, a process occurring by somatic hypermutation (SHM) in the lymphoid germinal centers, to become more specific in their recognition of antigens.

6 Aug 2021

Researchers identify genetic markers linked to COVID-19 severity and susceptibility

In collaboration with Northwestern Medicine investigators, an international multi-center study has identified genetic factors associated with SARS-CoV-2 infection and COVID-19 severity, according to findings published in Nature.

6 Aug 2021

New method for producing pseudotyped virus particles bearing spike protein of SARS-CoV-2

A new study discusses the development of an improved protocol based on cell lines that can consistently express S proteins.

5 Aug 2021

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Immunohistochemistry staining showing PD1 expression on tumor cells in a skin biopsy from a cutaneous T-cell lymphoma patient.

5 Aug 2021

Mutation in a single gene may be responsible for non-obstructive azoospermia in men

Mutation in a single gene appears to account for a form of male infertility in which men fail to produce sperm, according to an international study funded in part by the National Institutes of Health.

5 Aug 2021

UAB researchers identify potential therapeutic target for ovarian cancer

A gene called DOT1L appears to play a role in progression and severity of ovarian cancer, and inhibitors of the DOT1L enzyme may offer a new therapeutic approach for the disease, University of Alabama at Birmingham researchers say in a study published in the journal Oncogenesis.

5 Aug 2021

Postpartum sleep deprivation associated with accelerated biological aging

When new mothers complain that all those sleepless nights caring for their newborns are taking years off their life, they just might be right, UCLA research published this summer in the journal Sleep Health suggests.

5 Aug 2021

New DNA writing technique can precisely and efficiently edit bacterial genomes

Biological engineers at MIT have devised a new way to efficiently edit bacterial genomes and program memories into bacterial cells by rewriting their DNA.

5 Aug 2021

Vaccinia-based COVID-19 vaccines confer immunity in hamster model

In a paper recently uploaded to the preprint server bioRxiv* by Kulkarni et al. (August 3, 2021), the potential of vaccinia virus-based vaccines expressing the full-length SARS-CoV-2 spike protein is examined in mice and Syrian hamsters. The findings report that the vaccine generates high titers of neutralizing antibodies with good activity towards SARS-CoV-2 variants of concern.

5 Aug 2021

The role of natural killer cells in the fight against coronavirus infection

This study proposes a mathematical framework to analyze the effect of the viruses on type I interferon (IFN-I) signaling, which is part of the innate immune response. IFN-I brings about natural killer cell activation, which in turn causes the activation of macrophages.

4 Aug 2021

Study investigates the role of eIF4A3 protein in the growth of cancer cells

For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. In a new study published today in Science Advances, researchers at Karolinska Institutet in Sweden have investigated the protein eIF4A3 and its role in the growth of cancer cells.

4 Aug 2021

Researchers make a breakthrough in understanding the genesis of uterine leiomyomas

Scientists at the University of Helsinki and Helsinki University Hospital have made a breakthrough in understanding the genesis of uterine leiomyomas, also called fibroids.

4 Aug 2021

Study offers genetic insights into the underlying biology of reproductive aging

The age at which women go through menopause is critical for fertility and impacts healthy ageing in women, but reproductive ageing has been difficult for scientists to study and insights into the underlying biology are limited.

4 Aug 2021

Genes News and Research

Computational study identifies key areas of the SARS-CoV-2 genome prone to mutation

Surfactant-coated nanoparticle applications in nanomedicine and food

Long COVID may be due to persistent immune disturbances

Study uncovers link between corticosteroid receptors and ciliary, neuroplasticity genes in the brain

Education and employment experiences in early adulthood play a role in later life cardiovascular health

Research reveals a microRNA network as putative mediators of myocardial reductive stress

Researchers uncover new mitochondrial recycling pathway that may be linked to Parkinson’s disease

Affinity maturation of SARS-CoV-2 antibodies make them more powerful and resistant to escape mutations

Researchers identify genetic markers linked to COVID-19 severity and susceptibility

New method for producing pseudotyped virus particles bearing spike protein of SARS-CoV-2

PD1 gene deletions associated with worse prognoses of cutaneous T-cell lymphomas

Mutation in a single gene may be responsible for non-obstructive azoospermia in men

UAB researchers identify potential therapeutic target for ovarian cancer

Postpartum sleep deprivation associated with accelerated biological aging

New DNA writing technique can precisely and efficiently edit bacterial genomes

Vaccinia-based COVID-19 vaccines confer immunity in hamster model

The role of natural killer cells in the fight against coronavirus infection

Study investigates the role of eIF4A3 protein in the growth of cancer cells

Researchers make a breakthrough in understanding the genesis of uterine leiomyomas

Study offers genetic insights into the underlying biology of reproductive aging

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