Alzheimer's Disease News and Research

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Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.

Heptares exercises exclusive option to license new A2A antagonist for CNS disorders

Heptares Therapeutics, the leading GPCR drug discovery company, announces that an operating company of Shire PLC, the global specialty biopharmaceutical company, has exercised its exclusive option to license a novel adenosine A2A antagonist discovered by Heptares that is currently in preclinical development.

20 Mar 2012

Health must be taken into account in climate change mitigation strategies

Health must be taken into account in climate change mitigation strategies. It is not widely appreciated that there are many benefits to health that are likely to accrue from a low carbon economy, say experts in a special supplement published on bmj.com today.

20 Mar 2012

Technique developed to identify rogue clustering proteins in brain diseases

Australian researchers have developed a novel technique that tracks proteins “behaving badly” and may have found a way that leads to new treatments for brain disease. The team believes the discovery could help in the development of drugs to treat diseases such as Alzheimer's, Parkinson's and Huntington's.

19 Mar 2012

Novel technique rapidly identifies and tracks location of diseased proteins inside cells

A research team led by the University of Melbourne, Australia, has developed a novel technique that tracks diseased proteins behaving badly by forming clusters in brain diseases such as Huntington's and Alzheimer's.

19 Mar 2012

Merz launches new, once daily Mederma Advanced Scar Gel

Mederma, the #1 doctor-and pharmacist-recommended brand for scars for over a decade, announced today the introduction of Mederma Advanced Scar Gel, which reduces the overall appearance of scars caused by injury, acne, surgery or burns with just one daily application. Mederma Advanced Scar Gel contains Cepalin, the same proprietary botanical extract derived from onions used in all Mederma® scar products and stretch marks therapy.

19 Mar 2012

Klf4 protein an important regulator of inflammation: HNK study

Microglia are the first line defence of the brain and are constantly looking for infections to fight off. Overactive microglia can cause uncontrolled inflammation within the brain, which can in turn lead to neuronal damage. New research published in BioMed Central's open access journal Journal of Neuroinflammation shows that, honokiol (HNK) is able to down-regulate the production of pro-inflammatory cytokines and inflammatory enzymes in activated microglia via Klf4, a protein known to regulate DNA.

19 Mar 2012

Pfizer supports First World Congress on Healthy and Active Ageing

As an official partner of the First World Congress on Healthy Ageing, Pfizer reaffirms the company's commitment to promote healthy and active ageing at all stages of life as a basis for enhanced productivity in the Asia Pacific. Pfizer will lead a luncheon symposium today focused on the relationship between health and economic sustainability and the resulting challenges and opportunities of shifting demographics across the region.

19 Mar 2012

SBMT announces 2012 recipients of Pioneers in Medicine, Technology and Healthcare Policy Awards

Today, the Society for Brain Mapping & Therapeutics announced the 2012 recipients of the organization's prestigious Pioneers in Medicine, Technology, and Healthcare Policy Awards.

17 Mar 2012

ApoE4 gene could cause early loss of synapses in Alzheimer's disease

Today, researchers at the Blanchette Rockefeller Neurosciences Institute (BRNI) at West Virginia University in Morgantown, West Virginia reported a significant advance in understanding how different forms of the ApoE gene raise the risk for Alzheimer's disease.

17 Mar 2012

SK Biopharmaceuticals initiates YKP10811 phase 2 trial in chronic constipation

SK Biopharmaceuticals, a South Korean pharmaceutical company, announced today that the first patient was dosed in a phase 2 clinical trial in the US for patients suffering with chronic constipation using their new chemical entity YKP10811.

17 Mar 2012

Older women with mild retinopathy more likely to have cognitive decline and related vascular changes

Women 65 or older who have even mild retinopathy, a disease of blood vessels in the retina, are more likely to have cognitive decline and related vascular changes in the brain, according to a multi-institutional study led by scientists at the University of California, San Francisco (UCSF).

16 Mar 2012

Eight European research institutes partner to provide training on systemic neuroscience

Eight European research institutes, including Johannes Gutenberg University Mainz (JGU), and three commercial partners have joined forces in an EU project to provide young academics with an outstanding research environment in the field of systemic neuroscience.

16 Mar 2012

Viewpoints: Health costs crushing Detroit; Military care still faces funding issues; Romneycare scores

Legacy costs are bankrupting Detroit just as they crushed its automakers. Firefighters can retire at 55 and earn 70% of their highest salary plus a 2.25% annual cost-of-living inflator in perpetuity. The result? Employee benefits alone now make up about half of the city's general fund. Health costs have grown by more than 60% since 2008 while the city's pension bill has quadrupled to $200 million.

16 Mar 2012

Women with retinopathy more likely to have cognitive problems

People with mild vascular disease that causes damage to the retina in the eye are more likely to have problems with thinking and memory skills because they may also have vascular disease in the brain, according to a study published in the March 14, 2012, online issue of Neurology, the medical journal of the American Academy of Neurology.

15 Mar 2012

New UCLA Alzheimer's and Dementia Care program for patients, caregivers

Alzheimer's disease affects an estimated 5.4 million people in the U.S., some 480,000 of them in California. Nearly half of all people 85 and older will be stricken with the disease. The overall burden of dementia is still higher, with Alzheimer's accounting for only 60 to 80 percent of dementia cases.

15 Mar 2012

New RAGE inhibitor shows promise against Alzheimer's

Researchers have taken another crack at a promising approach to stopping Alzheimer's disease that encountered a major hurdle last year. In research published this week in the Journal of Clinical Investigation, scientists have developed a compound that targets a molecular actor known as RAGE, which plays a central role in mucking up the brain tissue of people with the disease.

15 Mar 2012

State roundup: Caregivers face 'burnout' threat as need grows, Kansas nursing home staff inadequate?

Long term care advocates say they're concerned about caregiver burnout. And they say Wisconsin may be overestimating projected savings from uncompensated care that relatives provide. State health officials need to find nearly $80 million in savings from a popular program that keeps the elderly and disabled out of nursing homes. The administration wants to know what assistance friends and family are giving so that care isn't replaced by Medicaid services.

15 Mar 2012

Potential new way to treat rare inherited metabolic disorders

A University of Michigan cell biologist and his colleagues have identified a potential drug that speeds up trash removal from the cell's recycling center, the lysosome.

14 Mar 2012

Microbubbles and focused ultrasound help drugs enter the brain

One of the trickiest parts of treating brain conditions is the blood brain barrier, a blockade of cells that prevent both harmful toxins and helpful pharmaceuticals from getting to the body's control center. But, a technique published in JoVE, uses an MRI machine to guide the use of microbubbles and focused ultrasound to help drugs enter the brain, which may open new treatment avenues for devastating conditions like Alzheimer's and brain cancers.

14 Mar 2012

Scientists gain insight into why lithium salts are effective at treating bipolar disorder

Scientists have gained insight into why lithium salts are effective at treating bipolar disorder in what could lead to more targeted therapies with fewer side-effects.

14 Mar 2012

Alzheimer's Disease News and Research

Further Reading

Heptares exercises exclusive option to license new A2A antagonist for CNS disorders

Health must be taken into account in climate change mitigation strategies

Technique developed to identify rogue clustering proteins in brain diseases

Novel technique rapidly identifies and tracks location of diseased proteins inside cells

Merz launches new, once daily Mederma Advanced Scar Gel

Klf4 protein an important regulator of inflammation: HNK study

Pfizer supports First World Congress on Healthy and Active Ageing

SBMT announces 2012 recipients of Pioneers in Medicine, Technology and Healthcare Policy Awards

ApoE4 gene could cause early loss of synapses in Alzheimer's disease

SK Biopharmaceuticals initiates YKP10811 phase 2 trial in chronic constipation

Older women with mild retinopathy more likely to have cognitive decline and related vascular changes

Eight European research institutes partner to provide training on systemic neuroscience

Viewpoints: Health costs crushing Detroit; Military care still faces funding issues; Romneycare scores

Women with retinopathy more likely to have cognitive problems

New UCLA Alzheimer's and Dementia Care program for patients, caregivers

New RAGE inhibitor shows promise against Alzheimer's

State roundup: Caregivers face 'burnout' threat as need grows, Kansas nursing home staff inadequate?

Potential new way to treat rare inherited metabolic disorders

Microbubbles and focused ultrasound help drugs enter the brain

Scientists gain insight into why lithium salts are effective at treating bipolar disorder

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How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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