Clinical Trial News and Research

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Trazodone linked to safer delirium outcomes in older adults

A large U.S. study suggests that older adults hospitalized with delirium may experience better outcomes when treated with trazodone, commonly used to treat depression and sleep problems, rather than commonly used antipsychotic medications.

3 Feb 2026

Lack of pediatric data restricts use of life-saving antibiotics

Life-saving antibiotics that could treat severe infections in babies and children aren't accessible due to a lack of data around safety and dosage, new research shows.

3 Feb 2026

Everday diabetes medicine linked to less progression of age-related macular degeneration

Doctors have found that metformin, an everyday medicine for diabetes, is associated with less progression of age-related macular degeneration (AMD), the commonest cause of blindness in western countries.

3 Feb 2026

Digital therapy significantly improves sexual function in women

Sexual dysfunction is a reality for many women, but the subject remains taboo. A large percentage of women remain untreated, a problem that is exacerbated by the shortage of treatment options for female sexual dysfunction.

3 Feb 2026

Study tests digital energy management tool for Long COVID

The first study to test a digital tool designed to help people with Long COVID manage their energy levels has been developed by a team of researchers.

2 Feb 2026

Diabetes drug use linked to fewer gout treatments

Natalie McCormick, PhD, of the Rheumatology and Allergy Clinical Epidemiology Research (RACER) Center within the Division of Rheumatology in the Mass General Brigham Department of Medicine, is the lead author of a paper published in Diabetes Care, "Gout-Related Medication Use After Initiating Sodium–Glucose Cotransporter 2 Inhibitors in Patients With Gout and Type 2 Diabetes: Population-Based Target Trial Emulation Studies."

2 Feb 2026

Clinical trial launched to test experimental intranasal spray against respiratory viruses

Last year, at least one million people in the U.S. were hospitalized for respiratory virus illnesses like the flu or COVID-19, according to the Centers for Disease Control and Prevention.

2 Feb 2026

Miniaturized ultrasound system may enable earlier detection of breast cancer

For people who are at high risk of developing breast cancer, frequent screenings with ultrasound can help detect tumors early. MIT researchers have now developed a miniaturized ultrasound system that could make it easier for breast ultrasounds to be performed more often, either at home or at a doctor's office.

2 Feb 2026

Targeted therapy for the less impaired arm improves movement for stroke survivors

Traditional stroke rehabilitation therapy focuses on restoring strength and movement to the more impaired side of the body, but a new randomized clinical trial has revealed that targeted therapy for the less impaired arm significantly improved movement and control for stroke survivors.

2 Feb 2026

Oxybutynin shows promise in managing hot flashes for prostate cancer patients

A national clinical trial led by the Alliance for Clinical Trials in Oncology has found that oxybutynin, a drug often used to treat overactive bladder symptoms, reduces hot flashes compared to the placebo in men receiving hormone therapy for prostate cancer.

2 Feb 2026

King’s researchers help transform UK mental health research infrastructure

King’s researchers will help transform mental health data, clinical trials and industry partnerships as part of the UK Government’s Mental Health Goals programme.

30 Jan 2026

Cannabis shows anti-migraine benefits

In a recent study, published in Headache: The Journal of Head and Face Pain, researchers at University of California San Diego School of Medicine demonstrate for the first time in a placebo-controlled clinical trial that cannabis is effective to treat acute migraine.

30 Jan 2026

AI-supported mammography improves early detection of breast cancer

Artificial intelligence (AI)-supported mammography identifies more cancers during screening and reduces the rate of breast cancer diagnosis by 12% in the years following, finds the first randomised controlled trial of its kind involving over 100,000 Swedish women published in The Lancet journal.

30 Jan 2026

Daily coffee intake linked to fewer atrial fibrillation relapses

The study reveals that moderate coffee consumption may lower atrial fibrillation recurrence risk post-cardioversion, highlighting coffee's potential benefits.

30 Jan 2026

Oral cancer pain and opioid tolerance share a common EGFR mechanism

Epidermal growth factor receptor (EGFR) signaling in the tissue around oral cancers both increases nerve sensitivity and makes opioids less effective, according to new research published in Science Signaling.

29 Jan 2026

Treating desmoplastic melanoma with immunotherapy before surgery can shrink or eliminate tumors

New results from a clinical trial co-led by UCLA investigators demonstrate how treating desmoplastic melanoma, a rare and aggressive skin cancer, with immunotherapy before surgery can dramatically shrink or even eliminate tumors, sparing patients from more aggressive surgeries and preserving their quality of life.

29 Jan 2026

Two-pronged therapeutic technology for cancer wins Pfizer Prize for Biomedical Research 2026

Whereas conventional treatments such as chemotherapy and radiotherapy show their limitations in battling certain advanced cancers, immunotherapy and therapeutic vaccines have opened up a new realm of hope for patients.

29 Jan 2026

Wake-promoting drug improves alertness in early morning shift workers

Many more people work very early morning shifts than overnight ones, and a large proportion struggle with excessive sleepiness from shift work disorder, leading to problems with focus, performance and safety.

29 Jan 2026

Poop pills could help cancer patients respond to immunotherapy while reducing toxic side effects

Fecal microbiota transplants (FMT), can dramatically improve cancer treatment, suggest two groundbreaking studies published in the prestigious Nature Medicine journal.

28 Jan 2026

Eating beef as part of a healthy dietary pattern does not impact risk factors for type 2 diabetes

More than 135 million American adults are either living with or at risk for type 2 diabetes (T2D), elevating the need for more evidence-based dietary guidance to help this growing population achieve optimal health and reduce risks for T2D and its complications.

28 Jan 2026

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Clinical Trial News and Research

Trazodone linked to safer delirium outcomes in older adults

Lack of pediatric data restricts use of life-saving antibiotics

Everday diabetes medicine linked to less progression of age-related macular degeneration

Digital therapy significantly improves sexual function in women

Study tests digital energy management tool for Long COVID

Diabetes drug use linked to fewer gout treatments

Clinical trial launched to test experimental intranasal spray against respiratory viruses

Miniaturized ultrasound system may enable earlier detection of breast cancer

Targeted therapy for the less impaired arm improves movement for stroke survivors

Oxybutynin shows promise in managing hot flashes for prostate cancer patients

King’s researchers help transform UK mental health research infrastructure

Cannabis shows anti-migraine benefits

AI-supported mammography improves early detection of breast cancer

Daily coffee intake linked to fewer atrial fibrillation relapses

Oral cancer pain and opioid tolerance share a common EGFR mechanism

Treating desmoplastic melanoma with immunotherapy before surgery can shrink or eliminate tumors

Two-pronged therapeutic technology for cancer wins Pfizer Prize for Biomedical Research 2026

Wake-promoting drug improves alertness in early morning shift workers

Poop pills could help cancer patients respond to immunotherapy while reducing toxic side effects

Eating beef as part of a healthy dietary pattern does not impact risk factors for type 2 diabetes

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