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The long-term consequences of SARS-CoV-2 infection in people with HIV

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from the United States (US) analyzed a cohort of patients with human immunodeficiency virus (HIV) (PWH) recovering from coronavirus disease 2019 (COVID-19) and characterized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in these patients.

15 Feb 2022

Antiviral potential of N-acylethanolamine acid amide hydrolase against SARS-CoV-2 and Zika virus

A recent study posted to the bioRxiv* pre-print server investigated the antiviral potential of N-acylethanolamine acid amidase (NAAA) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the Zika virus (ZIKV).

14 Feb 2022

Study reveals that 1PBC and niclosamide bind the same drug-binding pocket

Researchers used cryo-EM to demonstrate that 1PBC, and the drug niclosamide, both inhibitors of TMEM16 proteins, have therapeutic potential and may be used for COVID-19 treatment.

14 Feb 2022

Showcasing STEM Women in Medical Science

Every year, the UN celebrates the International Day of Women and Girls in Science. For 2022, the focus is placed on recognizing the role women and girls play in STEM as beneficiaries and as agents of change.

11 Feb 2022

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

The study highlights the significance of mix-and-match vaccine regimens to diversify the immune responses against highly mutated variants of SARS-CoV-2 such as Omicron.

10 Feb 2022

Impact of genetic changes in Omicron variant on an immunodominant T-cell epitope

Researchers describe the impact of changes in the Omicron variant on a uniquely immunodominant spike-encoded CD8+ T-cell epitope.

9 Feb 2022

Colchicine holds promise to reduce the risk of severe COVID-19

A recent article, published in Rheumatology and Therapy, reviews the potent evidence of colchicine against the SARS-CoV-2 infection.

7 Feb 2022

Study links COVID-19 inflammatory manifestations in brain lysates to Alzheimer’s Disease markers

In a new study, researchers investigated a link between the body’s inflammatory response to SARS-CoV-2 infection within the neuropathological pathways and tau hyperphosphorylation.

7 Feb 2022

Innate immune processes involved in SARS-CoV-2 recognition and resultant inflammation

A new article reviewed the innate immune detection and signaling pathways that the host uses against SARS-CoV-2.

7 Feb 2022

Researchers elucidate first 3D structure of regulator protein complex

Proteins are indispensable components in living organisms. They are not only "building material" for the body – they also make molecular communication between cells possible, they are needed for nerve impulses to occur, and they control chemical reactions.

2 Feb 2022

The ability of individuals to cross-recognize the Omicron spike protein following vaccination or prior infection

Scientists studied the ability of T cells to react with the Omicron spike.

2 Feb 2022

MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

Announcing a new review article publication for Acta Materia Medica journal. In this review article, the authors discuss the emerging neuroprotective function of MCL1 and how dysregulation of MCL1 signaling is involved in the pathogenesis of AD.

31 Jan 2022

Study reveals potential mechanism for iron accumulation in the aging brain

Breakdowns in regulatory mechanisms cause iron to build up in the brain as organisms grow older, increasing oxidative stress and causing cellular damage, according to a Northwestern Medicine study published in the journal eLife.

31 Jan 2022

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

In a new study, researchers evaluated SARS-CoV-2 vaccination-induced T cell responses cross-recognition among the early and novel SARS-CoV-2 variants.

26 Jan 2022

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

In a recent study, whole mRNA-seq was used to investigate the global effects of SARS-CoV-2 viral genes Nsp6, Nsp8, and M on the transcriptome of hPSC-CMs.

26 Jan 2022

Intracellular News and Research

The long-term consequences of SARS-CoV-2 infection in people with HIV

Antiviral potential of N-acylethanolamine acid amide hydrolase against SARS-CoV-2 and Zika virus

Study reveals that 1PBC and niclosamide bind the same drug-binding pocket

Showcasing STEM Women in Medical Science

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

Impact of genetic changes in Omicron variant on an immunodominant T-cell epitope

Colchicine holds promise to reduce the risk of severe COVID-19

Study links COVID-19 inflammatory manifestations in brain lysates to Alzheimer’s Disease markers

Innate immune processes involved in SARS-CoV-2 recognition and resultant inflammation

Researchers elucidate first 3D structure of regulator protein complex

The ability of individuals to cross-recognize the Omicron spike protein following vaccination or prior infection

MCL1 regulates neuronal autophagy, cell survival in Alzheimer's disease

Study reveals potential mechanism for iron accumulation in the aging brain

Cross-recognition of SARS-CoV-2 vaccine-elicited T cell responses among different variants

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

Novel gene therapy for diseased muscle fiber repair

Study sheds light on how melanoma primes nearby lymph nodes for tumor metastases

Exploring the potential utility of calcium channel inhibitors in SARS-CoV-2 infection

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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