Organoids News and Research

RSS

Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Gut's immune response to SARS-CoV-2 very different from the lung

Megan L. Stanifer et al. study the immune response in the human gut upon SARS-CoV-2 infection. The study published as a bioRxiv* preprint reveals a robust proinflammatory response: a cell type-specific or a tissue-specific regulation of interferon-mediated signaling during SARS-CoV-2 infection.

27 Oct 2020

Researchers generate a transcriptomic map of the COVID brain

COVID-19 is known to be associated with multiple changes in gene expression, but many of these are also seen in chronic brain conditions as well as in some abnormal mental conditions. A recent study published on the preprint server bioRxiv in October 2020 uncovers the molecular basis of this association.

26 Oct 2020

Researchers develop lab-grown lung model to study SARS-CoV-2 infection

A team of Duke University researchers has developed a lab-grown living lung model that mimics the tiny air sacs of the lungs where coronavirus infection and serious lung damage take place.

23 Oct 2020

'Mini-lungs' can provide important insights into how COVID-19 damages the lungs

'Mini-lungs' grown from tissue donated to Cambridge hospitals has provided a team of scientists from South Korea and the UK with important insights into how COVID-19 damages the lungs.

22 Oct 2020

Chip-based technology can create new options for ultrasound therapy with high resolution and intensity

A chip-based technology that generates sound profiles with high resolution and intensity could create new options for ultrasound therapy, which would become more effective and easier.

20 Oct 2020

Adult stem cell-based lung organoid models emulate host immune response in fatal COVID-19

Recently, a team of researchers from the University of California San Diego and The Scripps Research Institute, CA, USA, showed that an integrated stem cell-based disease modeling and computational approach is crucial for simulating the host immune response in fatal COVID-19 patients.

19 Oct 2020

Synthetic signals could help control tissue regeneration, guide cellular therapies

For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways.

16 Oct 2020

Physically squeezing cells can trigger cells to grow and divide faster

The closer people are physically to one another, the higher the chance for exchange, of things like ideas, information, and even infection.

14 Oct 2020

Researchers develop research model to understand the impact of coronavirus on lungs

Scientists at Boston University's National Emerging Infectious Diseases Laboratories (NEIDL) and the Center for Regenerative Medicine (CReM) joined forces to develop the most relevant research model possible for understanding how the coronavirus virus impacts the lungs, by engineering living, "breathing" human lung cells from stem cells for the task.

30 Sep 2020

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

A multinational research group recently published a paper in the journal Lancet Respiratory Medicine which describes the first patient with a severe form of coronavirus disease (COVID-19) that was successfully treated with human recombinant soluble ACE2.

27 Sep 2020

Researchers discover a hormone that might help tackle malabsorption

Scientists at Cincinnati Children's used human intestinal organoids grown from stem cells to discover how our bodies control the absorption of nutrients from the food we eat.

22 Sep 2020

BU researchers find how SARS-CoV-2 infection may drive deadly lung inflammation

Responding to the COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, requires models that can duplicate disease development in humans, identify potential targets and enable drug testing.

21 Sep 2020

Researchers generate accurate replications of human retinas in a dish

Scientists have generated accurate replications of human retinas in culture that can be used to pinpoint the specific types of cells affected by genetic eye diseases.

21 Sep 2020

New polygenic risk score to help predict the odds of drugs causing liver damage

The ancient Romans studied the livers of sacrificial animals to read omens and make prophesies. Now researchers at Tokyo Medical and Dental University and Takeda-CiRA program along with a world-wide team of collaborators, have devised a polygenic risk score (PRS) based on liver genomics that can predict the likelihood of medications causing liver damage.

19 Sep 2020

Salk institute to establish world-class consortium to study cellular and tissue aging in humans

The Salk Institute will establish a world-class San Diego Nathan Shock Center (SD-NSC), a consortium with Sanford Burnham Prebys Medical Institute (SBP) and the University of California San Diego (UC San Diego), to study cellular and tissue aging in humans.

17 Sep 2020

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Heart development as it happens in vivo, or in a living organism, is a complex process that has traditionally been difficult to mimic in vitro, or in the laboratory.

16 Sep 2020

Researchers identify specific potential therapeutic targets for aggressive form of pancreatic cancer

A team of researchers led by Mayo Clinic and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, has identified specific potential therapeutic targets for the most aggressive and lethal form of pancreatic cancer.

15 Sep 2020

Researchers receive $2.5 million grant to develop and analyze breast tumor organoids

Breast cancer is the second most common cancer diagnosed in women in the United States after skin cancer, and women with comorbidities (the presence of more than one condition/disease) often fare worse in terms of their breast cancer.

14 Sep 2020

Supplements of Human Milk Oligosaccharides may help improve gut health in adults

Supplements of Human Milk Oligosaccharides (HMOs), the sugars found in breast milk, may help improve the gut health of adults, according to new research carried out at the Quadram Institute.

14 Sep 2020

A new approach to study the role of Neandertal DNA during development

Protocols that allow the transformation of human induced pluripotent stem cell (iPSC) lines into organoids have changed the way scientists can study developmental processes and enable them to decipher the interplay between genes and tissue formation, particularly for organs where primary tissue is not available.

11 Sep 2020

Organoids News and Research

Further Reading

Gut's immune response to SARS-CoV-2 very different from the lung

Researchers generate a transcriptomic map of the COVID brain

Researchers develop lab-grown lung model to study SARS-CoV-2 infection

'Mini-lungs' can provide important insights into how COVID-19 damages the lungs

Chip-based technology can create new options for ultrasound therapy with high resolution and intensity

Adult stem cell-based lung organoid models emulate host immune response in fatal COVID-19

Synthetic signals could help control tissue regeneration, guide cellular therapies

Physically squeezing cells can trigger cells to grow and divide faster

Researchers develop research model to understand the impact of coronavirus on lungs

Human recombinant soluble ACE2 successfully used in a patient with severe COVID-19

Researchers discover a hormone that might help tackle malabsorption

BU researchers find how SARS-CoV-2 infection may drive deadly lung inflammation

Researchers generate accurate replications of human retinas in a dish

New polygenic risk score to help predict the odds of drugs causing liver damage

Salk institute to establish world-class consortium to study cellular and tissue aging in humans

Researchers develop 3D functional heart organoids from mouse embryonic stem cells

Researchers identify specific potential therapeutic targets for aggressive form of pancreatic cancer

Researchers receive $2.5 million grant to develop and analyze breast tumor organoids

Supplements of Human Milk Oligosaccharides may help improve gut health in adults

A new approach to study the role of Neandertal DNA during development

Optimizing 3D cryopreservation using Bambanker™ eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo