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A subunit SARS-CoV-2 vaccine may offer broader protection against virus

A new study published in the preprint server bioRxiv in September 2020 reports on the structure of this protein, as revealed by cryo-electron microscopy (cryoEM).

23 Sep 2020

Molecular dynamic simulations reveal detailed spike-ACE2 interactions

The current COVID-19 pandemic has spread throughout the world. Caused by a single-stranded RNA betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is closely related to but much more infectious than the earlier highly pathogenic betacoronaviruses SARS and MERS-CoV, has impacted social, economic, and physical health to an unimaginable extent.

23 Sep 2020

Common genetic variants may influence susceptibility to COVID-19

Researchers in the United States and Japan have conducted a study suggesting that a commonly occurring genetic variant influences susceptibility to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19).

23 Sep 2020

Research explains why flu is dangerous for pregnant women

A team of researchers at the Royal Melbourne Institute of Technology (RMIT) University explains why flu can lead to potentially fatal complications during pregnancy, suggesting that the virus does not only stay in the respiratory tract but spreads throughout the body.

22 Sep 2020

Hospitalized COVID-19 patients may face increased risk for kidney injury

Hospitalized patients with COVID-19 may face an increased risk for kidney injury, a dreaded complication for those suffering from infection with the novel 2019 coronavirus, an observational study led by University of Michigan researchers has found.

22 Sep 2020

Acquisition of a natural mutation primes SARS-CoV-2 for neutralization by a cross-reactive antibody

A team of scientists from the United States reveals that the acquisition of a natural mutation makes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptible to neutralization by a cross-reactive SARS-CoV antibody. The study is currently available on the bioRxiv* preprint server.

22 Sep 2020

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Researchers at the University of Cincinnati and UC Health will host a Phase 2 clinical trial (NCT04511650) to examine the effects of a drug that targets blood vessel inflammation and injury in patients with COVID-19.

22 Sep 2020

Exercise hormone could have a therapeutic effect on COVID-19 patients

A study conducted by researchers at São Paulo State University suggests that irisin, a hormone secreted from muscles in response to exercise, could have a therapeutic effect on COVID-19 patients.

22 Sep 2020

Men are dying from COVID-19 at a higher rate than women

A new review article from Beth Israel Deaconess Medical Center shows people who are biologically male are dying from COVID-19 at a higher rate than people who are biologically female.

22 Sep 2020

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

A phase 1 clinical trial of sotorasib (AMG 510) in patients with heavily pretreated advanced solid tumors shows encouraging anti-cancer activity, especially in lung and colorectal cancers, reports a new study led by City of Hope and other renowned comprehensive cancer centers.

22 Sep 2020

Nanoparticle SARS-CoV-2 model could potentially speed the search for drugs

A team of scientists from the National Center for Advancing Translational Sciences and Naval Research Laboratory in Washington, D.C., has developed a new tool that mimics how SARS-CoV-2 -- the virus that causes COVID-19 -- infects a cell, information that could potentially speed the search for treatments against the disease.

22 Sep 2020

A cost-effective scalable production of SARS-CoV-2 RBD in yeast

A new study by the Argentinian AntiCovid Consortium and published in the preprint server bioRxiv* in September 2020 reports on the successful characterization of the conformation and stability of the SARS-CoV-2 spike protein receptor-binding domain (RBD) in two different cell systems. This may help to accelerate the development of vaccines and neutralizing antibodies.

21 Sep 2020

Targeted therapy improves disease-free survival in patients with early-stage NSCLC

According to updated findings led by researchers at Yale Cancer Center, treatment with the targeted therapy osimertinib following surgery continues to significantly improve disease-free survival (DFS) in patients with early-stage, non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) gene mutations.

21 Sep 2020

Research uncovers potential cause of neurotoxicity due to immunotherapy

New research has uncovered the previously unknown presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB).

21 Sep 2020

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

A new study has revealed psoriatic arthritis may be activated by the same trigger in different patients. Researchers from the University of Oxford and the Wellcome Sanger Institute identified high levels of a specific receptor in immune cells from psoriatic arthritis patients, giving the strongest evidence yet of a single cause for the disease

21 Sep 2020

Type 1 diabetes is associated with increased risk of falls

New research presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD), held online this year (21-25 September), shows that having type 1 diabetes (T1D) is associated with a 33% increase in the risk of falls compared with the general population, while having type 2 diabetes (T2D) is associated with a 19% increased risk of falls.

21 Sep 2020

Soluble ACE2 microbody blocks SARS-CoV-2 entry into lung cells

A new study by researchers at NYU Langone Medical Center and Weill Cornell Medical College and published on the preprint server bioRxiv* in September 2020 reports the potential of an angiotensin-converting enzyme 2 (ACE2)-antibody Fc complex in a new format that seems to offer more significant inhibition of SARS-CoV-2.

21 Sep 2020

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, according to results from a study at ESMO 2020.

21 Sep 2020

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

A recent study published on the preprint server bioRxiv* seeks to establish the pattern of antibody reactivity in COVID-19 convalescent plasma (CCP), which is widely being used as a therapy for seriously ill COVID-19 patients.

21 Sep 2020

Researchers try and pop SARS-CoV-2 with an AFM tip - virion surprisingly resilient

Researchers at Semmelweis University and the National Public Health Center in Hungary have conducted an imaging study showing that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for coronavirus disease 2019 (COVID-19), is a highly dynamic and resilient virus

20 Sep 2020

Receptor News and Research

A subunit SARS-CoV-2 vaccine may offer broader protection against virus

Molecular dynamic simulations reveal detailed spike-ACE2 interactions

Common genetic variants may influence susceptibility to COVID-19

Research explains why flu is dangerous for pregnant women

Hospitalized COVID-19 patients may face increased risk for kidney injury

Acquisition of a natural mutation primes SARS-CoV-2 for neutralization by a cross-reactive antibody

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Exercise hormone could have a therapeutic effect on COVID-19 patients

Men are dying from COVID-19 at a higher rate than women

Sotorasib phase 1 trial shows encouraging anti-cancer activity in lung, colorectal cancers

Nanoparticle SARS-CoV-2 model could potentially speed the search for drugs

A cost-effective scalable production of SARS-CoV-2 RBD in yeast

Targeted therapy improves disease-free survival in patients with early-stage NSCLC

Research uncovers potential cause of neurotoxicity due to immunotherapy

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

Type 1 diabetes is associated with increased risk of falls

Soluble ACE2 microbody blocks SARS-CoV-2 entry into lung cells

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

COVAM assay may help select convalescent plasma units for treatment of acute COVID-19

Researchers try and pop SARS-CoV-2 with an AFM tip - virion surprisingly resilient

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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