Clinical Trial News and Research

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Cancer cells proliferate less when their internal pH is lowered, study shows

A new computational model has allowed researchers to identify new therapeutic targets that can attack cancer cells by lowering their intracellular pH. The study, which is the result of collaboration between IRB Barcelona, the Moffitt Cancer Center, and the University of Maryland, has been published in Nature Communications.

31 Jul 2018

FDA approves first therapy for patients with rare tumors of the adrenal gland

The U.S. Food and Drug Administration today approved Azedra (iobenguane I 131) injection for intravenous use for the treatment of adults and adolescents age 12 and older with rare tumors of the adrenal gland (pheochromocytoma or paraganglioma) that cannot be surgically removed (unresectable), have spread beyond the original tumor site and require systemic anticancer therapy.

31 Jul 2018

Ivosidenib receives FDA approval to treat acute myeloid leukemia patients with IDH1 mutation

Clinical trials at University of Colorado Cancer Center and elsewhere now result in the drug ivosidenib earning approval from the U.S. Food and Drug Administration for the treatment of adult patients with relapsed or refractory acute myeloid leukemia with a susceptible isocitrate dehydrogenase-1 mutation.

30 Jul 2018

BRAF inhibitors may be effective at treating rare ovarian cancer, study shows

New research has shown that ovarian cancer patients with a tumor mutation in the BRAF gene respond exceptionally well to treatment with targeted drugs, known as BRAF inhibitors.

30 Jul 2018

Pairing online patient dashboard with 'nudges' to doctors triples statin prescribing rates

Pairing an online patient dashboard with "nudges" to doctors tripled statin prescribing rates in a clinical trial led by Penn Medicine researchers.

27 Jul 2018

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

OHSU scientists have discovered a naturally occurring disease in monkeys that mimics a deadly childhood neurodegenerative disorder in people - a finding that holds promise for developing new gene therapies to treat Batten disease.

27 Jul 2018

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Novartis today announced the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a positive opinion recommending approval of Tafinlar® in combination with Mekinist® for the adjuvant treatment of adult patients with stage III melanoma with a BRAF V600 mutation, following complete resection.

27 Jul 2018

Therapy with L-Glutamine reduces pain in patients with sickle cell disease

UCSF Benioff Children's Hospital Oakland clinical researchers, in conjunction with other sickle cell centers and scientists at Emmaus Life Sciences, Inc., have demonstrated that therapy with L-Glutamine reduced the frequency of pain episodes in both pediatric and adult patients with sickle cell disease.

27 Jul 2018

Newer version of ALS drug may effectively treat inherited form of the disease

NIH-funded researchers delayed signs of amyotrophic lateral sclerosis in rodents by injecting them with a second-generation drug designed to silence the gene, superoxide dismutase 1.

27 Jul 2018

Brain scan can help select the right Parkinson’s patients for clinical trials

From today forward, researchers and drug companies have a new tool in the search for better treatments for Parkinson’s – a brain scan that can be used to select the right people for clinical trials.

27 Jul 2018

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Certara, the global leader in model-informed drug development, regulatory science, market access and real-world evidence services, announced today that Clinical Pharmacology & Therapeutics has published its "Letter to the Editor" describing the important role that quantitative systems pharmacology can play in defining dosing criteria for first-in-human clinical trials, together with the European Medicines Agency's response.

26 Jul 2018

Study supports clinical role of biomarker test to rule out the need for CT scan in TBI patients

Banyan Biomarkers, Inc., a pioneer in developing biomarkers for traumatic brain injury (TBI), today announced the publication of the results for the ALERT-TBI study, an international, multicenter clinical trial utilizing the Banyan Brain Trauma Indicator.

26 Jul 2018

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

New research gives insights into how the design of clinical trials can improve to address the "critically low" research pipeline and improve the chances of finding effective dementia therapies.

26 Jul 2018

Long-lasting HIV control without antiretroviral therapy is a feasible goal, says expert

Long-lasting control of HIV infection without antiretroviral therapy is a feasible goal that deserves vigorous pursuit, Anthony S. Fauci, M.D., will assert during a lecture on Wednesday, July 25 at the 22nd International AIDS Conference in Amsterdam.

26 Jul 2018

Aggressive lowering of blood pressure reduces MCI risk, study shows

Significant reductions in the risk of mild cognitive impairment (MCI), and the combination of MCI and dementia, have been shown for the first time through aggressive lowering of systolic blood pressure in new research results from the federally-funded SPRINT MIND Study reported at the Alzheimer's Association International Conference 2018 in Chicago.

25 Jul 2018

New data shows that simple blood test accurately diagnoses Peripheral Artery Disease

Prevencio, Inc., announces the publication of data that demonstrates a simple new blood test accurately diagnoses significant Peripheral Artery Disease, a circulatory problem in which plaque-narrowed arteries reduce blood flow to a patient's limbs and kidneys.

25 Jul 2018

Pediatric sepsis care within an hour increases chances of survival, shows study

More than one in 10 children hospitalized with sepsis die, but when a series of clinical treatments and tests is completed within an hour of its detection, the chances of survival increase considerably, according to a new analysis led by the University of Pittsburgh School of Medicine.

25 Jul 2018

Viagra in pregnancy trial stopped after 11 newborn babies died

A Dutch clinical trial was looking at the potential of Sildenafil or impotence drug Viagra to improve the growth in unborn babies of pregnant women. The study had to be stopped prematurely after the death of eleven babies.

25 Jul 2018

Researchers report first randomized trial results of 'kick and kill' approach to treat HIV

Researchers have reported the results of the first randomized clinical trial to test a novel strategy involving waking up and then killing the 'sleeping' HIV that is hiding in the body using an experimental approach known as 'kick and kill'.

24 Jul 2018

People with type 2 diabetes likely to benefit from 5:2 diet, study shows

People with type 2 diabetes are just as likely to lose weight and control their blood glucose levels if they follow a 5:2 diet than an ongoing daily calorie-restricted diet, according to a world-first study by University of South Australia researchers.

24 Jul 2018

Clinical Trial News and Research

Cancer cells proliferate less when their internal pH is lowered, study shows

FDA approves first therapy for patients with rare tumors of the adrenal gland

Ivosidenib receives FDA approval to treat acute myeloid leukemia patients with IDH1 mutation

BRAF inhibitors may be effective at treating rare ovarian cancer, study shows

Pairing online patient dashboard with 'nudges' to doctors triples statin prescribing rates

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

Novartis' new drug combination receives positive CHMP opinion for treating stage III BRAF mutant melanoma

Therapy with L-Glutamine reduces pain in patients with sickle cell disease

Newer version of ALS drug may effectively treat inherited form of the disease

Brain scan can help select the right Parkinson’s patients for clinical trials

Experts describe role of quantitative systems pharmacology in first-in-human clinical trials

Study supports clinical role of biomarker test to rule out the need for CT scan in TBI patients

Study gives insights into how better clinical trials can address ‘critically low’ dementia research

Long-lasting HIV control without antiretroviral therapy is a feasible goal, says expert

Aggressive lowering of blood pressure reduces MCI risk, study shows

New data shows that simple blood test accurately diagnoses Peripheral Artery Disease

Pediatric sepsis care within an hour increases chances of survival, shows study

Viagra in pregnancy trial stopped after 11 newborn babies died

Researchers report first randomized trial results of 'kick and kill' approach to treat HIV

People with type 2 diabetes likely to benefit from 5:2 diet, study shows

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