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New fluorescent label provides a clearer picture of how DNA architecture is disrupted in cancer cells

Researchers have developed a new fluorescent label that gives a clearer picture of how DNA architecture is disrupted in cancer cells. The findings could improve cancer diagnoses for patients and classification of future cancer risk.

4 Mar 2022

Researchers design a peptide hydrogel for cell spheroids production

This study is led by Prof. Zhimou Yang and Prof. Quan Chen (College of Life Sciences in Nankai University), and Prof. Jianfeng Liu (Institute of Radiation Medicine, Chinese Academy of Medical Sciences). Prof. Zhimou Yang, who is working in the research field of peptide self-assembly biomaterials for more than 15 years, designed the peptide hydrogel for cell spheroids production.

4 Mar 2022

RT-LAMP assay shows promise as point-of-care SARS-CoV-2 detection assay across multiple settings

Researchers evaluate the feasibility and robustness of an optimized RT-LAMP SARS-CoV-2 detection assay across multiple resource-restricted settings.

4 Mar 2022

8G3 broad-spectrum antibody effective against all SARS-CoV-2 variants, including Omicron

Researchers assess the efficacy of 8G3, a B-cell neutralizing antibody against SARS-CoV-2 variants, including the most recent Omicron variant.

3 Mar 2022

World's first Microhub makes spatial context accessible for all

New Mica imaging platform from Leica Microsystems brings previously inaccessible experiments to all life science researchers

From Leica Microsystems GmbH 3 Mar 2022

DeNovix to give away Platinum Edition CellDrop™ Automated Cell Counter in celebration of prestigious award

DeNovix Inc. is giving away a Platinum Edition CellDrop™ Automated Cell Counter to celebrate the instrument’s newly awarded Platinum Seal of Quality from SelectScience.

From DeNovix Inc. 2 Mar 2022

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Researchers used deep mutational scans to measure the effect of each amino-acid mutation in the receptor-binding domain of SARS-CoV-2 Wuhan-Hu-1, Alpha, Beta, Delta, and Eta variants.

1 Mar 2022

Mechanism behind how certain osmolytes cause kidney damage revealed

Researchers from Tokyo Metropolitan University have uncovered the mechanism by which osmolytes used to treat high fluid pressure in the eye and skull can cause kidney damage.

27 Feb 2022

Study reports persistent SARS-CoV-2 lingering within tissues of patients with long COVID

Researchers investigated whether residual SARS-CoV-2 antigens and RNA are present in tissues samples of long COVID-19 patients beyond the convalescent phase of COVID-19.

24 Feb 2022

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

Researchers developed a hybrid assay incorporating immunological antibody-based viral spike protein capture with molecular nucleic acid amplification by qRT-PCR.

24 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

Low-cost, non-invasive device uses light and saliva to quickly test Covid-19 patients

A team of researchers from ICFO and IrsiCaixa report on the development of a low-cost, portable, non-invasive device that uses light and saliva to test Covid-19 patients in less than 30 min.

22 Feb 2022

New method to develop nanoengineered bacteria for photothermal cancer immunotheranostics

There is substantial interest regarding the understanding and designing of nanoengineered bacteria to combat various fatal cancerous diseases.

22 Feb 2022

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Researchers investigate the potential of picolinic acid (PA) as an anti-SARS-CoV-2 treatment option.

21 Feb 2022

Optical genome mapping holds potential to become an important component of leukemia diagnostics

Optical genome mapping involves the extraction of very long DNA molecules, for example routinely collected blood samples or bone marrow material from patients.

17 Feb 2022

Developing nanoplatforms for direct drug delivery to T cells

T cells, also known as lymphocytes, have important roles in various immune reactions. However, there are only a few reports on delivery systems into T cells. Realizing this, it is essential to work and actively contribute in controlling immune systems.

16 Feb 2022

CRISPR-Cas12a assay to diagnose SARS-CoV-2 infection and detect strain-specific SNPs for variant identification

The multiplex detection approach outlined in this study has the potential to address the need to rapidly characterize the phenotype and clinical response to continually emerging SARS-CoV-2 variants as the COVID-19 pandemic continues.

16 Feb 2022

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

In a recent study posted to the medRxiv* preprint server, researchers evaluated the cross-reactivity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant-triggered neutralization and fragment crystallizable (Fc) effector functions between coronavirus disease 2019 (COVID-19)-vaccinated and unvaccinated individuals in South Africa.

16 Feb 2022

Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

In a recent study posted to the bioRxiv* preprint server, the team of researchers explored the protein-protein interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 1 (Nsp1) and host 40S and 43S ribosomal subunits.

15 Feb 2022

Nitazoxanide shows promise for COVID-19 treatment in animal model

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that Nitazoxanide (NTZ), an oral drug, broadly inhibits replication of several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in preclinical models of infection.

13 Feb 2022

Fluorescence News and Research

New fluorescent label provides a clearer picture of how DNA architecture is disrupted in cancer cells

Researchers design a peptide hydrogel for cell spheroids production

RT-LAMP assay shows promise as point-of-care SARS-CoV-2 detection assay across multiple settings

8G3 broad-spectrum antibody effective against all SARS-CoV-2 variants, including Omicron

World's first Microhub makes spatial context accessible for all

DeNovix to give away Platinum Edition CellDrop™ Automated Cell Counter in celebration of prestigious award

Epistatic shifts rationalize mutational constraints of SARS-CoV-2 receptor-binding domain

Mechanism behind how certain osmolytes cause kidney damage revealed

Study reports persistent SARS-CoV-2 lingering within tissues of patients with long COVID

Immunomolecular detection method to rapidly and accurately detect complete SARS-CoV-2 virions

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

Low-cost, non-invasive device uses light and saliva to quickly test Covid-19 patients

New method to develop nanoengineered bacteria for photothermal cancer immunotheranostics

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Optical genome mapping holds potential to become an important component of leukemia diagnostics

Developing nanoplatforms for direct drug delivery to T cells

CRISPR-Cas12a assay to diagnose SARS-CoV-2 infection and detect strain-specific SNPs for variant identification

Superior immune response in vaccinated after infection with Omicron compared to unvaccinated

Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

Nitazoxanide shows promise for COVID-19 treatment in animal model

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Advancing degrader and proximity-based drug development

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Evaluating new approaches for rare disease genomics

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