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Microphysiological systems in drug discovery

NewsMedical speaks with CN Bio about the translatability between in vitro organ-on-a-chip (OOC) models, microphysiological systems, and their in vivo counterparts.

From CN Bio 26 Feb 2025

Lung expansion interventions fail to reduce breathing problems after abdominal surgery

A new study, published today in The Lancet Respiratory Medicine, tested whether a set of interventions to keep lungs expanded before, during, and after abdominal surgery could lower the risk of serious breathing problems in patients compared to the usual care at 17 academic hospitals in the U.S.

25 Feb 2025

Water-only fasting boosts human growth hormone without weight loss

Fasting for 24 hours increases human growth hormone (HGH) levels independently of weight loss, with individuals with lower baseline HGH experiencing the most significant increases. The study suggests metabolic benefits from fasting, particularly for those with lower HGH levels.

25 Feb 2025

Cooling treatment shows no benefits for preterm infants with hypoxic ischemic encephalopathy

Lowering the body temperature of preterm infants (born at 33 to 35 weeks of pregnancy) with hypoxic ischemic encephalopathy (HIE)-a type of brain damage caused by oxygen loss-offers no benefits over standard care, according to a study funded by the National Institutes of Health (NIH).

25 Feb 2025

Advanced MRI uncovers lung abnormalities in children and teens with long COVID

An advanced type of MRI uncovers significant lung abnormalities in children and adolescents with long COVID, according to a new study published today in Radiology, a journal of the Radiological Society of North America .

25 Feb 2025

New mechanism uncovered to combat therapy-resistant cancer cells

One particular challenge in the treatment of cancer is therapy resistance. An international research team has now discovered a mechanism that opens up new treatment strategies for tumors in which conventional chemotherapeutic agents have reached their limits.

25 Feb 2025

Scientists aim to regenerate lungs for premature infants with BPD

Understanding resilience - the ability of injured lung tissue to heal and regenerate - may be key to advancing the treatment and prevention of life-threatening lung disease that occurs in extremely premature babies, a new study suggests.

25 Feb 2025

Understanding the causes and symptoms of obstructive sleep apnea

Do you feel tired or have a headache when you wake up in the morning? Something might be going wrong while you sleep that you don't know about: obstructive sleep apnea (pronounced app-nee-uh).

24 Feb 2025

Why over 5 billion people still lack access to life-saving medical oxygen

The Lancet Global Health Commission highlights severe inequities in medical oxygen access, urging systemic reforms to ensure universal availability and affordability.

23 Feb 2025

ETH Zurich team uncovers mechanism behind microbubble drug delivery

ETH Zurich researchers have investigated how tiny gas bubbles can deliver drugs into cells in a targeted manner using ultrasound.

22 Feb 2025

Engineered blood vessel cells boost islet transplant success in diabetes treatment

Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study led by Weill Cornell Medicine investigators.

21 Feb 2025

Antioxidant-enzyme interactions and their role in non-communicable diseases

Oxidative stress, caused by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a central role in the development of non-communicable diseases (NCDs).

21 Feb 2025

New 3D lung model advances respiratory medicine research

Respiratory diseases are a challenging problem to treat. Inhalable medicines are a promising solution that depend on the ability to deliver tiny particles known as aerosols to the correct location in the lungs at the correct dosage.

20 Feb 2025

Nerinetide shows promise in stroke treatment meta-analysis

The Calgary Stroke Program, a joint University of Calgary and Alberta Health Services initiative at Foothills Medical Centre, has been involved with three papers published this week in The Lancet and Lancet Neurology-the ESCAPE-NEXT trial, the FRONTIER trial, and an individual patient-level meta-analysis across three trials.

19 Feb 2025