Therapeutics News and Research

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Understanding post-traumatic vasospasm as a hidden complication of traumatic brain injury

A new review published in the Journal of Intensive Medicine on 25 July, 2025 and led by Dr. Alice Jacquens and Dr. Clara Perrault from Pitié Salpêtrière Hospital, Paris, France, sheds light on an under-recognized complication of traumatic brain injury (TBI): post-traumatic vasospasm (PTV).

17 Oct 2025

LassoESM accelerates discovery of therapeutic peptides

In the hunt for new therapeutics for cancer and infectious diseases, lasso peptides prove to be a catch.

16 Oct 2025

New enzyme offers cleaner route to more stable diabetes and obesity drugs

Chemistry researchers at the University of Utah have uncovered an enzyme, dubbed PapB, that can "tie off" therapeutic peptides-protein-like drugs-into tight rings, a process known as macrocyclization.

16 Oct 2025

MXene materials pave the way for next-generation smart contact lenses

As wearable health technologies evolve, smart contact lenses (SCLs) are emerging as powerful platforms for non-invasive, real-time ocular diagnostics.

16 Oct 2025

Mass General Brigham study shows US obesity could jump from 40% to 70%

The prevalence of obesity in the United States could rise sharply under a new definition of obesity released earlier this year by the Lancet Diabetes and Endocrinology Commission.

16 Oct 2025

New European trial tests subcutaneous EEG technology for people with epilepsy

A new clinical trial co-led by researchers at FutureNeuro and RCSI University of Medicine and Health Sciences is investigating how advanced brain monitoring could improve the diagnosis and management of epilepsy.

16 Oct 2025

Caraway seeds inspire new seizure-fighting medicines

A UNLV-led team of researchers has co-opted a common kitchen spice to create a new class of cannabidiol (CBD)-like medicines that show powerful seizure-reducing effects - offering a safer, more affordable, and more effective treatment for childhood seizure disorders than existing frontline therapies.

15 Oct 2025

CRISPR therapy shows promise against influenza in human lung chips

The Influenza A virus (IAV) has been the cause of six major flu pandemics, responsible for 50 to 100 million deaths globally.

15 Oct 2025

Experimental gene therapy restores immune system function in children with genetic immune disorder

An experimental gene therapy developed by researchers at UCLA, University College London and Great Ormond Street Hospital has restored and maintained immune system function in 59 of 62 children born with ADA-SCID, a rare and deadly genetic immune disorder.

15 Oct 2025

Gene therapy shows long-term success in children with rare immune disorder

Results from the largest cohort of children who received a gene therapy for a rare immunodeficiency condition have shown the long-term safety and efficacy of the curative treatment, in a study led by a UCL researcher.

15 Oct 2025

New AI system connects hidden clues in medical records to transform diagnosis

Doctors often must make critical decisions in minutes, relying on incomplete information. While electronic health records contain vast amounts of patient data, much of it remains difficult to interpret quickly-especially for patients with rare diseases or unusual symptoms.

15 Oct 2025

Psychedelics could alter treatment paradigms for stress-related mental health conditions

A peer-reviewed viewpoint article published today in Psychedelics by Prof. Xiaohui Wang and colleagues examines the therapeutic potential of psychedelic substances for treating stress-related psychiatric disorders through novel neurobiological mechanisms.

14 Oct 2025

Engineered antibody triggers powerful anti-tumor response in advanced cancers

Many advanced cancers develop resistance to treatment and become highly aggressive, often leaving patients with limited treatment options.

13 Oct 2025

Bridging innovation and equity to end cervical cancer worldwide

Each year, more than 340,000 women die from cervical cancer, with the majority of deaths occurring in low- and middle-income countries.

13 Oct 2025

Scalable synthetic biology revolutionizes targeted therapy with logic-gate proteins

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint the exact areas of the body where they're needed - and nowhere they're not - can reduce the medicine dosage and avoid potentially harmful "off target" effects elsewhere in the body.

10 Oct 2025

Breakthrough in cancer therapy targets key protein interaction to suppress tumors

Researchers at the Francis Crick Institute and Vividion Therapeutics have identified chemical compounds that can precisely block the interaction between the major cancer-driving gene RAS, and a key pathway for tumor growth.

9 Oct 2025

First global standard published to measure outcomes in dengue treatment trials

The first global standard which harmonizes what outcomes to measure in dengue treatment trials has been published this week in The Lancet Infectious Diseases. Co-led by researchers at King's and the University of Oxford, this solves a longstanding discrepancy in terms of what is measured in these trials.

9 Oct 2025