Insulin News and Research

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Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.

Calorie restriction causes temporal changes in the liver and skeletal muscle metabolism

Moderate calorie restriction causes temporal changes in the liver and skeletal muscle metabolism, whereas moderate weight loss affects muscle, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.

4 May 2009

Discovery of possible preventative therapy for type 1 diabetes

Scientists believe they may have found a preventative therapy for type 1 diabetes, by making the body's killer immune cells tolerate the insulin-producing cells they would normally attack and destroy, prior to disease onset.

29 Apr 2009

Even modest exercise improves insulin sensitivity, decreases fat in the liver and inflammation in belly fat

A new University of Illinois study suggests that moderate amounts of exercise alone can reduce the inflammation in visceral fat - belly fat, if you will - that has been linked with metabolic syndrome, a group of risk factors that predict heart disease and Type 2 diabetes.

23 Apr 2009

Mitochondrial peptide Humanin linked to neuronal cell survival and regulation of glucose metabolism

Recent studies have shown that the mitochondrial peptide Humanin (HN) protects against neuronal cell death such as happens in Alzheimer's disease.

22 Apr 2009

Diabetes, obesity and hypertension increase mortality in hepatitis C patients

The specific impact of metabolic syndrome on mortality in hepatitis C patients has been revealed by new research to be presented on Sunday April 26 at EASL 2009, the Annual Meeting of the European Association for the Study of the Liver in Copenhagen, Denmark.

22 Apr 2009

Sleep pattern influences risk of type 2 diabetes

Researchers at University Laval's Faculty of Medicine have found that people who sleep too much or not enough are at greater risk of developing type 2 diabetes or impaired glucose tolerance.

22 Apr 2009

Discovery of agents that speed up destruction of amyloid beta proteins

Taking a new approach to the treatment and prevention of Alzheimer's disease, a research team led by investigators at the Mayo Clinic campus in Florida has shown that druglike compounds can speed up destruction of the amyloid beta (A-beta) proteins that form plaque in the brains of patients with the disorder.

22 Apr 2009

Poor sleep disturbs neuroendocrine control of appetite

Laboratory and epidemiological studies continue to show that sleep curtailment and/or decreased sleep quality can disturb neuroendocrine control of appetite, leading to overeating, and can decrease insulin and/or increase insulin resistance, both steps on the road to Type 2 diabetes.

22 Apr 2009

Too much sugar is bad, but which sugar is worse: Fructose or glucose?

In 2005, the average American consumed 64kg of added sugar, a sizeable proportion of which came through drinking soft drinks.

21 Apr 2009

Psoriasis increases risk for developing diabetes and hypertension in women

Women with psoriasis appear to have an increased risk for developing diabetes and hypertension (high blood pressure), according to a report in the April issue of Archives of Dermatology.

21 Apr 2009

Survival mode that protects cells when oxygen is low also slows aging

A biochemical pathway that helps keep cells alive when oxygen is low also plays a role in longevity and resistance against some diseases of old age, according to a report to be published April 16 in the journal Science.

16 Apr 2009

Type 1 diabetes controlled by stem cell transplants therapy

Scientists in the United States have found that stem cell transplants enabled people with type 1 diabetes to manage for as long as four years without needing insulin injections and to maintain good glycemic control - such patients typically need daily insulin therapy to control their diabetes.

15 Apr 2009

Pancreatic islets show promise in diabetes research, treatments

The use of pancreatic islets (hormone-producing cells) is increasing in diabetes research and may play an important role in future treatments, according to an article in the April 15 issue of JAMA, the Journal of the American Medical Association.

14 Apr 2009

Stem cell transplantation helps patients with diabetes become insulin free

The majority of patients with type 1 diabetes who underwent a certain type of stem cell transplantation became insulin free, several for more than three years, with good glycemic control, and also increased C-peptide levels, an indirect measure of beta-cell function, according to a study in the April 15 issue of JAMA, the Journal of the American Medical Association.

14 Apr 2009

Rockefeller University Hospital opens clinical trial into statin-associated muscle complaints

The most widely prescribed class of drugs in the country, statins have helped millions of people lower their cholesterol and reduce their risk of heart attacks - but their side effects, including muscle pain and cramping, have proven to be something of a sore point for many patients.

14 Apr 2009

New understanding of roles of insulin in obesity or type II diabetes

Researchers have uncovered new evidence suggesting factors other than genes could cause obesity, finding that genetically identical cells store widely differing amounts of fat depending on subtle variations in how cells process insulin.

14 Apr 2009

Experimental insulin-like growth factor receptor inhibitor a clear clinical candidate for pancreatic cancer therapy

Researchers at Amgen are testing a fully human monoclonal antibody that inhibits the activity of insulin-like growth factors (IGF-1 and IGF-2) and appears to reduce pancreatic cancer cells in early testing, according to a report in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research.

14 Apr 2009