Inflammation News and Research

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Why does convalescent plasma therapy for severe COVID-19 show mixed success?

A surprising new preprint, released on the medRxiv* server, suggests that the beneficial effects of convalescent plasma (CP) in this disease stem not only from the presence of neutralizing antibodies, but also the immunomodulatory effects of this plasma that shapes the host immune response.

15 Mar 2021

Which biomarkers can help predict severe COVID-19?

The ability to detect potentially fatal illness early on in the course of the disease would enable a swift prioritization of these high-risk individuals for treatment. A new preprint on the medRxiv* server presents an array of biomarkers that may help achieve this laudable goal.

15 Mar 2021

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

In a recent bioRxiv preprint research paper, Botond Z. Igyártó and colleagues from Thomas Jefferson University demonstrated the inflammatory nature of the lipid nanoparticles (LNPs).

15 Mar 2021

Overexpression of signaling protein in heart associated with poor survival after heart attack

About 6.2 million Americans suffer from heart failure, an incurable disease with a staggering mortality rate - some 40 percent of patients die within five years of diagnosis. Heart failure is one form of heart disease, for which new therapies are desperately needed.

13 Mar 2021

Cancer cells may dodge chemotherapy by going into 'active hibernation'

Cancer cells can dodge chemotherapy by entering a state that bears similarity to certain kinds of senescence, a type of "active hibernation" that enables them to weather the stress induced by aggressive treatments aimed at destroying them, according to a new study by scientists at Weill Cornell Medicine.

13 Mar 2021

How common are post-acute sequelae of SARS-CoV-2 infection?

The COVID-19 pandemic has taken a heavy toll on human lives, with over two million casualties so far. Equally devastating has been its economic toll. Now, a new study describes the features and frequency of long-haul symptoms in COVID-19.

12 Mar 2021

Impact of type I interferon (IFN) autoantibodies in critical COVID-19

A new preprint discusses the pathogenesis of this critical COVID-19 with reference to autoimmune phenomena involving the key antiviral type I interferon pathway.

12 Mar 2021

Novel tool can add or remove sugar from proteins

Sugar has been called "evil," "toxic," and "poison." But the body needs sugars, too. Sugar molecules help cells recognize and fight viruses and bacteria, shuttle proteins from cell to cell, and make sure those proteins function.

12 Mar 2021

Exposure to COVID-19 can cause rare but life-threatening pediatric condition

Exposure to SARS-Co-V2, the virus that causes COVID-19, can put otherwise healthy children and adolescents at risk for Multisystem Inflammatory Syndrome in Children (MIS-C), a rare but possibly life-threatening pediatric condition that can cause severe inflammation in organs like the heart, brain, lungs, kidneys and gastrointestinal system.

12 Mar 2021

Researchers discover new protein that may play a key role in atherosclerosis

Atherosclerosis is the underlying condition that causes heart attacks and strokes. Researchers at Radboudumc in the Netherlands have discovered a protein that appears to play an important role in atherosclerosis.

11 Mar 2021

One in four people could face some degree of hearing loss by 2050, WHO report warns

One in four people across the world — nearly 2.5 billion — could face some degree of hearing loss by 2050 with at least 700 million requiring access to treatment and rehabilitation, a WHO report warns.

11 Mar 2021

Electric stimulation increases permeability of the blood vessels to speed wound healing

Electric stimulation may be able to help blood vessels carry white blood cells and oxygen to wounds, speeding healing, a new study suggests.

11 Mar 2021

High obesity rates in Southern states magnify Covid threat

In January, as Mississippi health officials planned for their incoming shipments of covid-19 vaccine, they assessed the state's most vulnerable: health care workers, of course, and elderly people in nursing homes.

11 Mar 2021

SARS-CoV-2 can infect blood monocytes and trigger inflammation, finds study

Researchers found about 10% of blood monocytes in coronavirus disease 2019 (COVID-19) patients are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). These monocytes then die, leading to the release of cytokines – a feature associated with severe and critical COVID-19.

11 Mar 2021

Probiotic supplements increase the diversity of intestinal bacteria in extremely preterm infants

Extremely preterm infants can suffer from a life-threatening inflammation of the gut. A new clinical study has shown that supplements of a lactic acid bacterium may have positive effects by increasing the diversity of intestinal bacteria in these infants.

11 Mar 2021

Study: Graphene nanoparticles interfere with the development of anxiety-related behaviors in vertebrates

New research shows that the nanomaterial acts on the excitatory synapses, interfering with the development of anxiety related behaviors in vertebrates.

11 Mar 2021

SARS-CoV-2 spike S1 subunit induces hypercoagulability

The vascular complications of the condition include a range of various coagulopathies that cause bleeding and thrombocytopenia or a hypercoagulable state. A new preprint research paper posted to the medRxiv server describes the role of a fibrinogen-related protein in inducing these clinical features of COVID-19.

10 Mar 2021

Study examines central nervous system imaging manifestations of COVID-19 in children

While neurological complications of COVID-19 in children are rare, in contrast to adults, an international expert review of positive neuroimaging findings in children with acute and post-infectious COVID-19 found that the most common abnormalities resembled immune-mediated patterns of disease involving the brain, spine, and nerves.

10 Mar 2021

Researchers shed light on T-cell receptor activation in response to infection

Immune cells specialize to ensure the most efficient defense against viruses and other pathogens. Researchers at the University of Basel have shed light on this specialization of T cells and shown that it occurs differently in the context of an acute and a chronic infection.

10 Mar 2021

NTU scientists design new compound that could help reduce overactive immune response

When the body detects a pathogen, such as bacteria or viruses, it mounts an immune system response to fight this invader. In some people, the immune system overreacts, resulting in an overactive immune response that causes the body to injure itself, which may prove fatal in some cases.

10 Mar 2021

Inflammation News and Research

Why does convalescent plasma therapy for severe COVID-19 show mixed success?

Which biomarkers can help predict severe COVID-19?

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

Overexpression of signaling protein in heart associated with poor survival after heart attack

Cancer cells may dodge chemotherapy by going into 'active hibernation'

How common are post-acute sequelae of SARS-CoV-2 infection?

Impact of type I interferon (IFN) autoantibodies in critical COVID-19

Novel tool can add or remove sugar from proteins

Exposure to COVID-19 can cause rare but life-threatening pediatric condition

Researchers discover new protein that may play a key role in atherosclerosis

One in four people could face some degree of hearing loss by 2050, WHO report warns

Electric stimulation increases permeability of the blood vessels to speed wound healing

High obesity rates in Southern states magnify Covid threat

SARS-CoV-2 can infect blood monocytes and trigger inflammation, finds study

Probiotic supplements increase the diversity of intestinal bacteria in extremely preterm infants

Study: Graphene nanoparticles interfere with the development of anxiety-related behaviors in vertebrates

SARS-CoV-2 spike S1 subunit induces hypercoagulability

Study examines central nervous system imaging manifestations of COVID-19 in children

Researchers shed light on T-cell receptor activation in response to infection

NTU scientists design new compound that could help reduce overactive immune response

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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