Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Abnormalities in mitochondrial length promote development of neurodegenerative diseases

Goldilocks was on to something when she preferred everything "just right." Harvard Medical School researchers have found that when it comes to the length of mitochondria, the power-producing organelles, applying the fairy tale's mantra is crucial to the health of a cell. More specifically, abnormalities in mitochondrial length promote the development of neurodegenerative diseases such as Alzheimer's.

24 Aug 2012

New method can differentiate between breast cancer patients with good and poor prognosis

It is now possible to identify aggressive breast cancers by interpreting the mathematical patterns in the cancer genome. Researchers at the University of Oslo, Norway (UiO) have developed a completely new method for differentiating between breast cancer patients with high and low risks of dying from the illness.

24 Aug 2012

LXRbeta may play a role in prevention and treatment of Parkinson's

Scientists at the University of Houston (UH) have discovered what may possibly be a key ingredient in the fight against Parkinson's disease.

24 Aug 2012

S45F mutation may offer identifiable risk factor in recurrent pediatric aggressive fibromatosis

In the case of aggressive fibromatosis, the good news is that it is a slow-growing benign tumor. The bad news is that this abdominal tumor often recurs after surgical removal. This is particularly true among children. While headway has been made in isolating causes of this recurrence in adults, it is less clear in children.

23 Aug 2012

Laminin-111 protein therapy could treat Duchenne muscular dystrophy

A novel treatment in development at the University of Nevada School of Medicine for the most common form of muscular dystrophy is advancing towards human trials with a $308,000 boost from the Muscular Dystrophy Association.

23 Aug 2012

APSSLH and Maney collaborate to launch Speech, Language and Hearing journal

Starting in 2013 Maney will be collaborating with the Asia Pacific Society for the Study of Speech, Language and Hearing (APSSLH) to launch Speech, Language and Hearing. This is a significant development for both Maney and the Society.

23 Aug 2012

Mof protein plays a key role in epigenetics of stem cells

How do stem cells preserve their ability to become any type of cell in the body? And how do they "decide" to give up that magical state and start specializing? If researchers could answer these questions, our ability to harness stem cells to treat disease could explode. Now, a University of Michigan Medical School team has published a key discovery that could help that goal become reality.

22 Aug 2012

VolitionRX to initiate NuQ blood-based tests in colorectal cancer clinical trial

VolitionRX Limited, a life sciences company focused on developing blood-based diagnostic tests, announces that its subsidiary Belgian Volition has signed an agreement with the Biobank of CHU UCL Mont-Godinne, an academic hospital in Yvoir, Belgium.

22 Aug 2012

Kineta receives regulatory clearance to commence ShK-186 Phase I trial in autoimmune disease

Seattle-based biotech company Kineta, Inc. announced today it has received regulatory clearance in the Netherlands to initiate a first-in-human trial of ShK-186, an autoimmune drug candidate that specifically inhibits the Kv1.3 potassium ion channel.

21 Aug 2012

Hemodialysis foot ulcer risk not confined to diabetes

Hemodialysis patients with and without diabetes are at risk for foot ulceration, say UK researchers who believe preventive resources must be directed towards both patient groups.

20 Aug 2012

Parkinson’s disease with dementia falls into two pathologic subgroups

Patients with Parkinson’s disease who also have dementia fall into two main pathologic categories, characterized by neocortical synucleinopathy in isolation and neocortical synucleinopathy with amyloid beta deposition.

20 Aug 2012

Pyruvate kinase M2 fuels tumor growth by influencing H3 histone protein

A metabolic protein that nourishes cancer cells also activates tumor-promoting genes by loosening part of the packaging that entwines DNA to make up chromosomes, a team led by scientists at The University of Texas MD Anderson Cancer Center reports in the Aug. 16 issue of Cell.

17 Aug 2012

U-M, IGC launch new joint venture for personalized medicine

As a key step toward providing patients with treatments based on their own DNA profiles, the University of Michigan and the International Genomics Consortium (IGC) have launched a new joint venture that will help usher in an age of personalized medicine.

17 Aug 2012

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Researchers have discovered molecular and protein signatures that predict rapid onset of liver damage in hepatitis C patients following a liver transplant. The markers appeared soon after transplant and well before clinical evidence of liver damage.

17 Aug 2012

Hemodialysis foot ulcer risk not confined to diabetes

Hemodialysis patients with and without diabetes are at risk for foot ulceration, say UK researchers who believe preventive resources must be directed toward both patient groups.

16 Aug 2012

Researchers discover why people with sickle cell disease get milder cases of malaria

Researchers at Duke University Medical Center may finally have discovered why people with sickle cell disease get milder cases of malaria than individuals who have normal red blood cells.

16 Aug 2012

Scientists devise new fluorescent probes to diagnose neurodegenerative diseases

Sticky plaques of proteins called amyloids mark several different, though related degenerative brain diseases including Alzheimer's, Parkinson's and Creutzfeld-Jacobs. The symptoms of these disorders overlap and methods to diagnose and monitor them are not very advanced.

16 Aug 2012

White matter abnormalities distinguish childhood-onset BD

Increased white matter microstructure abnormalities may differentiate pediatric- from adult-onset bipolar disorder, results from a US study suggest.

15 Aug 2012

Mindfulness meditation prevents feelings of loneliness

Many elderly people spend their last years alone. Spouses pass and children scatter. But being lonely is much more than a silent house and a lack of companionship. Over time, loneliness not only takes a toll on the psyche but can have a serious physical impact as well.

15 Aug 2012

Latrepiridine reduces level of at least two neurodegeneration-related proteins in mice

The second of two studies on latrepirdine, recently published in Molecular Psychiatry, demonstrates new potential for the compound in the treatment of Alzheimer's disease, Parkinson's disease, sleep disorders, and other neurodegenerative conditions.

14 Aug 2012

Pathology News and Research

Further Reading

Abnormalities in mitochondrial length promote development of neurodegenerative diseases

New method can differentiate between breast cancer patients with good and poor prognosis

LXRbeta may play a role in prevention and treatment of Parkinson's

S45F mutation may offer identifiable risk factor in recurrent pediatric aggressive fibromatosis

Laminin-111 protein therapy could treat Duchenne muscular dystrophy

APSSLH and Maney collaborate to launch Speech, Language and Hearing journal

Mof protein plays a key role in epigenetics of stem cells

VolitionRX to initiate NuQ blood-based tests in colorectal cancer clinical trial

Kineta receives regulatory clearance to commence ShK-186 Phase I trial in autoimmune disease

Hemodialysis foot ulcer risk not confined to diabetes

Parkinson’s disease with dementia falls into two pathologic subgroups

Pyruvate kinase M2 fuels tumor growth by influencing H3 histone protein

U-M, IGC launch new joint venture for personalized medicine

Researchers identify molecular and protein signatures that predict HCV virus-induced liver injury

Hemodialysis foot ulcer risk not confined to diabetes

Researchers discover why people with sickle cell disease get milder cases of malaria

Scientists devise new fluorescent probes to diagnose neurodegenerative diseases

White matter abnormalities distinguish childhood-onset BD

Mindfulness meditation prevents feelings of loneliness

Latrepiridine reduces level of at least two neurodegeneration-related proteins in mice

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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