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Oral targeted therapy shrinks tumors in over 70% of patients with HER2-mutant NSCLC

The oral targeted therapy sevabertinib led to tumor reduction and manageable side effects in patients with HER2-mutant non-small cell lung cancer (NSCLC), according to data from a trial led by researchers at The University of Texas MD Anderson Cancer Center.

22 Oct 2025

Study shows mRNA-based COVID vaccines enhance effectiveness of immune checkpoint therapy

Patients with cancer who received mRNA-based COVID vaccines within 100 days of starting immune checkpoint therapy were twice as likely to be alive three years after beginning treatment, according to a new study led by researchers at The University of Texas MD Anderson Cancer Center.

22 Oct 2025

Can strawberries help prevent diabetes? New trial shows promising results in prediabetic adults

Daily consumption of freeze-dried strawberries for 12 weeks improved antioxidant defense, reduced inflammation, and lowered fasting glucose in adults with prediabetes. The randomized crossover trial highlights strawberries’ potential as a simple, food-based strategy to enhance metabolic and vascular health.

21 Oct 2025

Gut bacteria found to make serotonin and boost intestinal motility

Researchers have identified Limosilactobacillus mucosae and Ligilactobacillus ruminis as human gut bacteria capable of producing serotonin by decarboxylating 5-hydroxytryptophan (5-HTP). Their activity enhances intestinal motility and enteric nerve density, linking microbial serotonin synthesis to gut function and potential IBS mechanisms.

21 Oct 2025

Fortress, filter, and gatekeeper: New insights into how the blood-brain barrier safeguards the brain

Researchers provide a comprehensive overview of the blood-brain barrier (BBB), detailing its cellular architecture, transport mechanisms, and role in protecting the brain from toxins. The paper highlights how BBB dysfunction contributes to neurological diseases and explores emerging technologies to overcome drug delivery challenges.

21 Oct 2025

Epigenetic editing enables safer and more effective T cell therapies

Arc Institute, Gladstone Institutes, and University of California, San Francisco, scientists have developed an epigenetic editing platform that enables safe modification of multiple genes in primary human T cells, addressing a key manufacturing and scalability challenge in next-generation cell therapies.

21 Oct 2025

HCS-3DX platform enables large-scale, high-precision screening of cellular models

The HCS-3DX platform performs automated analysis of three-dimensional cell cultures, known as spheroids.

21 Oct 2025

Researchers develop a novel approach to monitor CD8⁺ T cell activity over time

The ability of immune cells-particularly CD8+ T cells-to launch a rapid burst of proliferation inside tumors is key to the success of modern day cancer immunotherapies.

21 Oct 2025

New discovery could someday help prevent breast cancer recurrence

Know someone who's been diagnosed with breast cancer? There's a good chance that person has received hormone therapy.

21 Oct 2025

Stressful life factors early in life may triple the risk of developing psoriasis later

New longitudinal research reveals that severe stress caused by changes in family structure like divorce or separation experienced during the first year of life may triple the risk of developing psoriasis later in life.

21 Oct 2025

Using placental growth factor to predict preeclampsia risk in pregnant women with sickle cell disease

In pregnant women with sickle cell disease, the risk of developing early-onset preeclampsia can be determined by measuring levels of a protein associated with placental function and development.

21 Oct 2025

New AI-driven approach identifies treatments to reprogram and destroy cancer stem cells

Scientists at University of California San Diego have developed a new approach to destroying cancer stem cells – hard-to-find cells that help cancers spread, come back after treatment and resist therapy.

21 Oct 2025

Corneas from diabetic donors perform well in vision restoring surgeries

Many eye banks won't accept corneas from donors with diabetes, concerned they might be harder to prepare for transplant surgery or are more likely to fail.

21 Oct 2025

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

A large international study involving nearly 700 participants reveals that women with a precursor condition to Parkinson's disease show significantly less brain atrophy—decreased cortical thickness in the brain—than men, despite similar clinical severity.

21 Oct 2025

Study clarifies the complex interaction between gut bacteria and common gastrointestinal disorder

Research from the University of Gothenburg, Sweden, clarifies the complex interaction between gut bacteria and IBS.

21 Oct 2025

Researchers develop a new approach for treating children with neuroblastoma

A research team from the University of Zurich and the University Children's Hospital Zurich has developed a new approach for treating children with malignant tumors of the nervous system.

21 Oct 2025

Study provides a new approach for the treatment of prostate tumors

An international research team led by the Medical University of Vienna has demonstrated for the first time that thyroid hormone plays a key role in the development and progression of prostate cancer.

21 Oct 2025

BMAC treatment accelerates healing for ACL, MCL, and meniscus tears

Bone marrow aspirate concentrate (BMAC) is a common treatment for joint injuries.

21 Oct 2025

AGA updates guidelines for Barrett's Esophagus to catch cancer early

The American Gastroenterological Association (AGA) released a new clinical practice guideline on the surveillance of Barrett's esophagus, the only known precursor to esophageal cancer (adenocarcinoma), a highly lethal cancer whose incidence has risen substantially over recent decades.

21 Oct 2025

Largest trial of adjuvant pembrolizumab in Merkel cell carcinoma reports key benefit

A new cancer clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) shows that a drug that utilizes the body's immune system to target and eliminate cancer cells appeared to reduce the risk of distant metastases for an aggressive form of skin cancer when given immediately after surgery, but did not significantly reduce the overall risk of recurrence, which was a co-primary endpoint of the trial.

21 Oct 2025

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B Cell News and Research

Oral targeted therapy shrinks tumors in over 70% of patients with HER2-mutant NSCLC

Study shows mRNA-based COVID vaccines enhance effectiveness of immune checkpoint therapy

Can strawberries help prevent diabetes? New trial shows promising results in prediabetic adults

Gut bacteria found to make serotonin and boost intestinal motility

Fortress, filter, and gatekeeper: New insights into how the blood-brain barrier safeguards the brain

Epigenetic editing enables safer and more effective T cell therapies

HCS-3DX platform enables large-scale, high-precision screening of cellular models

Researchers develop a novel approach to monitor CD8⁺ T cell activity over time

New discovery could someday help prevent breast cancer recurrence

Stressful life factors early in life may triple the risk of developing psoriasis later

Using placental growth factor to predict preeclampsia risk in pregnant women with sickle cell disease

New AI-driven approach identifies treatments to reprogram and destroy cancer stem cells

Corneas from diabetic donors perform well in vision restoring surgeries

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

Study clarifies the complex interaction between gut bacteria and common gastrointestinal disorder

Researchers develop a new approach for treating children with neuroblastoma

Study provides a new approach for the treatment of prostate tumors

BMAC treatment accelerates healing for ACL, MCL, and meniscus tears

AGA updates guidelines for Barrett's Esophagus to catch cancer early

Largest trial of adjuvant pembrolizumab in Merkel cell carcinoma reports key benefit

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