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TET1 identified as key regulator in cancer and chronic disease

Recent findings shed new light on the critical role of TET1, a pivotal player in epigenetic regulation, in the development and progression of various clinical diseases.

25 Jun 2025

Is aspartame safe for blood sugar? Study answers the big question

A major systematic review and meta-analysis found that aspartame has little to no effect on blood glucose, insulin, or appetite-regulating hormones in humans. Evidence certainty is very low, with no significant long-term metabolic impact identified.

25 Jun 2025

Once-monthly obesity injection shows double-digit weight loss in major clinical trial

Researchers found that once-monthly maridebart cafraglutide led to substantial weight loss and improved glycemic control in adults with obesity, with or without diabetes, in a phase 2 randomized trial. The drug demonstrated an acceptable safety profile and supports further study in phase 3 trials.

24 Jun 2025

Stress-activated gene damages insulin-producing cells in type 2 diabetes

Stress does no one - not even your insulin-producing cells - any good.

24 Jun 2025

Fructose consumption increases immune cell sensitivity to bacterial toxins

Despite medical advances, infectious diseases caused by bacteria and viruses are still among the most common causes of death worldwide.

24 Jun 2025

Excess trace metal levels may trigger gestational diabetes

Excess micronutrients in early pregnancy may raise gestational diabetes risks. Study links essential metal levels to GDM onset, urging a rethink on supplements.

24 Jun 2025

New study links social factors to racial disparities in weight loss surgery outcomes

Weight loss surgery has long been an effective treatment for the more than 40 percent of American adults struggling with obesity.

24 Jun 2025

Clinical trial finds new benefits of semaglutide for adults with type 1 diabetes

A new clinical trial found that taking a popular diabetes and weight-loss drug once weekly significantly improves blood sugar and leads to substantial weight loss in adults with Type 1 diabetes who use automated insulin delivery systems.

23 Jun 2025

Cagrilintide and semaglutide together drive record weight loss in global trial

A 68-week phase 3 trial found that coadministered cagrilintide and semaglutide led to significant and clinically meaningful weight loss in adults with obesity but no diabetes. The combination outperformed either drug alone and improved multiple cardiometabolic health markers.

23 Jun 2025

Amycretin delivers unprecedented weight loss in early trial for obesity treatment

Once-weekly amycretin, a novel peptide activating GLP-1, amylin, and calcitonin receptors, produced rapid, substantial, and sustained weight loss in adults with overweight or obesity during a phase 1b/2a trial. The treatment was generally well tolerated, with mostly mild to moderate gastrointestinal side effects, supporting further investigation in larger, longer studies.

23 Jun 2025

Use of sleep heart rate patterns to forecast diabetes risk in pregnancy

This study highlights the potential of heart rate variability as an early indicator of gestational diabetes, facilitating proactive healthcare in pregnancy.

23 Jun 2025

Assessment of insulin resistance using TyG index flags rapid cognitive decline in Alzheimer's patients

Insulin resistance detected by routine triglyceride-glucose (TyG) index can flag people with early Alzheimer's who are four times more likely to present rapid cognitive decline, according to new research presented at the European Academy of Neurology (EAN) Congress 2025.

22 Jun 2025

Men lose more weight than women on the keto diet, new study reveals why

Men lose more weight than women on a ketogenic diet, according to a comprehensive review in Frontiers in Nutrition. Sex differences in hormones, metabolism, and fat distribution influence the effectiveness of the ketogenic diet for obesity.

22 Jun 2025

New 3D immunohistochemistry method enhances deep tissue imaging

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues.

19 Jun 2025

How early-life factors raise lifelong diabetes risks in youth

The surge in diabetes among young people highlights critical gaps in care and the urgent need for comprehensive preventative actions to address this crisis.

19 Jun 2025

Time-restricted feeding restores microbial rhythms and boosts metabolism

The gut microbiome, a vast assortment of bacteria and other microorganisms that inhabit our digestive system, plays a critical role in converting food into energy.

19 Jun 2025

Can salt substitutes lower blood pressure in diabetes? A new Cochrane review aims to find out

Researchers will systematically review whether replacing regular sodium salt with alternatives like potassium or magnesium salts helps lower blood pressure in adults with diabetes. The protocol outlines a rigorous plan to evaluate blood pressure effects, safety, and adherence using data from RCTs and quasi-RCTs.

18 Jun 2025

New data show COVID-19 triggers spike in new diabetes cases

A large cohort study in California state prisons found that COVID-19 infection modestly but significantly increases the risk of developing new-onset diabetes. The elevated risk persists for months after infection, even when accounting for confounding factors and diagnostic intensity.

18 Jun 2025

Oxytocin stimulates pancreatic hormones to improve insulin secretion

A new research paper was published in Aging (Aging-US) Volume 17, Issue 5, on May 1, 2025, titled "Oxytocin modulates insulin and GLP-1 secretion in pancreatic islets."

18 Jun 2025

Gut microbiome resists major changes from a nut-rich diet

The systematic review highlights that while nuts influence gut microbiota, the effects are modest and vary by nut type, warranting further investigation.

18 Jun 2025