Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Children with minimal change nephrotic syndrome can be treated with prednisone

A kidney condition that can arise in children and was until recently believed to disappear after puberty may persist into adulthood and cause significant long-term complications, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN). The findings indicate that better treatment options are needed for children with the disorder, called minimal change nephrotic syndrome.

25 Sep 2009

Computational models form basis to design the device for recreating kidney function

Researchers from Mount Sinai School of Medicine and two other academic institutions have received federal funding to systematically assemble functional human kidney tissue from tissue modeled on a computer. If successful, the research-which ties together several emerging technologies including virtual tissue modeling and nanofabrication-could lead to a more predictable way for researchers to engineer tissue outside the body and, consequently, to screen for new drugs.

24 Sep 2009

VisEn launches new imaging agent for monitoring key hypertension and renal disease biomarker

VisEn Medical Inc., a leader in fluorescence in vivo imaging from research through medicine, announced today the commercial launch of its new ReninSense680(TM) FAST imaging agent for measuring and monitoring a key hypertension and renal disease biomarker in vivo.

24 Sep 2009

Research study links high-fructose diet to increased blood pressure in men

A high-fructose diet raises blood pressure in men, while a drug used to treat gout seems to protect against the blood pressure increase, according to research reported at the American Heart Association's 63rd High Blood Pressure Research Conference.

24 Sep 2009

Researchers visualize vasculature within native liver cyst walls of human ADPKD patients

As part of an effort to develop effective medical therapies that block the progression of liver cyst growth in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), researchers at the University of Colorado Anschutz Medical Center have found that the liver cyst walls develop and maintain a vasculature as they grow out from the body of the liver and that factors released by epithelial cells that line the liver cyst wall lumen can drive the proliferation and development of vascular endothelial cells.

24 Sep 2009

Phase 2 trial results of Bayer's Nexavar in combination with capecitabine announced

Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced the full results from their first collaborative group-sponsored randomized, double-blind, placebo-controlled Phase 2 trial showing that Nexavar(R) (sorafenib) tablets in combination with the oral chemotherapeutic agent, capecitabine, significantly extended progression-free survival in patients with advanced breast cancer.

23 Sep 2009

New drug test promises to yield quick and effective response for cancer therapy

A group of scientists from Hamburg may have taken a big step towards more effective cancer drug development, Europe's largest cancer congress, ECCO 15 - ESMO 34 [1], heard today (Wednesday 23 September). Dr Ilona Schonn, Director of Cell Culture Research at Indivumed GmbH, told the conference that they had developed a preclinical drug test platform that would enable researchers to analyse tumour tissue for individual patient drug responses on the molecular level.

23 Sep 2009

Sorafenib with chemotherapy for breast cancer patients had a 74% percent improvement in the time they lived

One of the first of a series of trials to investigate the use of sorafenib - a targeted anti-cancer drug - for the treatment of advanced breast cancer has found that if it is combined with the chemotherapy drug, capecitabine, it makes a significant difference to the time women live without their disease worsening.

23 Sep 2009

Pros and cons of the estimated Glomerular Filtration Rate

As many as 26 million Americans live with chronic kidney disease (CKD) and according to the National Institutes of Health (NIH), at least 10.4 million (or 40%) don't even know they have it. Enter the estimated Glomerular Filtration Rate (eGFR), which has become the preferred method for identifying people with CKD.

23 Sep 2009

NIH, NephCure Foundation and University of Michigan support study of nephrotic syndrome

University of Michigan Health System researchers will lead a $10.25 million effort to study rare kidney diseases that cause kidney failure and the need for dialysis.

23 Sep 2009

$1.2 million grant to study centrosomes and cilia and their connections to human disease

If you don't know how a human cell is supposed to work, it's hard to offer a good explanation when the cell goes haywire -- as it does in cancer. That's why a Florida State University College of Medicine researcher has been awarded a $1.2 million grant to explore the role of centrosomes and cilia in cell division and development and their connections to human disease.

22 Sep 2009

NIDDK grants HealthPartners Research Foundation $7.3M to study childhood obesity

Three new HealthPartners Research Foundation studies will examine ways to prevent and treat childhood obesity and hypertension. One study will look at interventions to prevent obesity in children ages 5-9, another will focus on obesity prevention in children ages 2-5, while another will examine hypertension in children and adolescents, including the quality and cost of care.

21 Sep 2009

Many Australians at risk of having a heart attack are not receiving the best possible care: Study

The research suggests that GPs are still managing individual risk factors such as blood pressure and cholesterol in isolation of one another, and are not adopting recommendations to treat a patient's overall or absolute risk. Absolute risk management is based on the principle that the major risk factors for cardiovascular disease act together. By taking this approach treatment can be targeted to those most likely to benefit.

21 Sep 2009

Vitae Pharmaceuticals initiates Phase 1 clinical trial of its novel cardiovascular agent

Vitae Pharmaceuticals, Inc., an integrated discovery and development company, today announced that it has initiated a Phase 1 clinical trial of its novel cardiovascular agent, VTP-27999.

21 Sep 2009

The Transcatheter Cardiovascular Therapeutics 2009 to feature PLCs' RenalGuard System

PLC Systems Inc. (OTC Bulletin Board: PLCSF), a company focused on innovative cardiac and vascular medical device-based technologies, today announced that it will demonstrate its RenalGuard System(TM) at Transcatheter Cardiovascular Therapeutics (TCT) 2009, sponsored by the Cardiovascular Research Foundation, September 21 - 25, 2009, in San Francisco, California. More than 11,000 clinicians and professionals are expected to attend this event.

21 Sep 2009

Dialysis patient embarks on "Grandpa's Road Trip" with NxStage System One hemodialysis machine

NxStage Medical, Inc. (Nasdaq: NXTM), a leading manufacturer of innovative dialysis products, today announced that home dialysis patient Harvey Wells, 57, has embarked on his third annual "Grandpa's Road Trip" with the NxStage(R) System One(TM). As a portable home hemodialysis machine, the NxStage System One provides Mr. Wells the opportunity to fit hemodialysis therapy into his own lifestyle and schedule. Mr. Wells is once again celebrating this freedom by traveling the country in his RV and sharing with other patients his experience doing home daily hemodialysis with the NxStage System One.

21 Sep 2009

Program to promote patients’ overall health following kidney transplant surgery

Patient adherence after a kidney transplant, or faithfully following a prescribed medical regimen, is vital to a transplant recipient's health and the survival of their new organ.

19 Sep 2009

Texas attemps to offer access to quality dialysis care

Local officials, physicians and patients in need of local dialysis care expressed encouragement over what appears to be a thawing of a certification logjam of dialysis facilities across the state of Texas, though remain concerned over 38 which still remain idling to many for more than a year – to the detriment of local jobs and patients in dire need of better access to quality dialysis care.

18 Sep 2009

Perot Systems to provide IT outsourcing and EHR implementation for MHC

Max Healthcare (MHC) (www.maxhealthcare.in) and Perot Systems Corporation (NYSE: PER) (www.perotsystems.com) today announced a 10-year agreement in which Perot Systems will provide IT outsourcing (ITO) and electronic health records (EHR) implementation for MHC.

18 Sep 2009

Recipients of 2009 Norman S. Coplon Extramural Grants

Satellite Healthcare, one of the nation's first and leading providers of kidney dialysis services and a major sponsor of nephrology research, today announced the recipients of the 2009 Norman S. Coplon Extramural Grant Program.

18 Sep 2009

Nephrology News and Research

Further Reading

Children with minimal change nephrotic syndrome can be treated with prednisone

Computational models form basis to design the device for recreating kidney function

VisEn launches new imaging agent for monitoring key hypertension and renal disease biomarker

Research study links high-fructose diet to increased blood pressure in men

Researchers visualize vasculature within native liver cyst walls of human ADPKD patients

Phase 2 trial results of Bayer's Nexavar in combination with capecitabine announced

New drug test promises to yield quick and effective response for cancer therapy

Sorafenib with chemotherapy for breast cancer patients had a 74% percent improvement in the time they lived

Pros and cons of the estimated Glomerular Filtration Rate

NIH, NephCure Foundation and University of Michigan support study of nephrotic syndrome

$1.2 million grant to study centrosomes and cilia and their connections to human disease

NIDDK grants HealthPartners Research Foundation $7.3M to study childhood obesity

Many Australians at risk of having a heart attack are not receiving the best possible care: Study

Vitae Pharmaceuticals initiates Phase 1 clinical trial of its novel cardiovascular agent

The Transcatheter Cardiovascular Therapeutics 2009 to feature PLCs' RenalGuard System

Dialysis patient embarks on "Grandpa's Road Trip" with NxStage System One hemodialysis machine

Program to promote patients’ overall health following kidney transplant surgery

Texas attemps to offer access to quality dialysis care

Perot Systems to provide IT outsourcing and EHR implementation for MHC

Recipients of 2009 Norman S. Coplon Extramural Grants

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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