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Decoding DNA packing: Understanding nucleosomes' role in cellular efficiency

Each cell in our bodies carries about two meters of DNA in its nucleus, packed into a tiny volume of just a few hundred cubic micrometers-about a millionth of a milliliter. The cell manages this by winding the strings of DNA around protein spools. The protein-DNA complexes are called nucleosomes, and they ensure that DNA is safely stored.

28 Jul 2025

Scientists open new atlas of genetic diversity with advanced sequencing

A global team mapped over 100,000 structural variants in human genomes by applying Oxford Nanopore long-read sequencing and a novel graph-based analytical approach to samples from 26 populations. The study reveals the extraordinary complexity and diversity of human DNA, providing an open-access atlas that will accelerate discoveries in genetic disease and human evolution.

24 Jul 2025

Standard DNA tests miss most cases of NUT carcinoma

The diagnosis of a suspected lung, head, and neck cancer called NUT carcinoma should include additional testing capable of detecting gene fusions that are definitive markers of the disease, according to a study by Dana-Farber Cancer Institute investigators.

24 Jul 2025

Automated cage monitoring system reveals behavioral changes in schizophrenia mouse model

Schizophrenia is a serious mental health condition that affects thoughts, moods, perceptions, and behaviors.

24 Jul 2025

Promising therapeutic approach identified for multiple myeloma

Researchers at Uppsala University have identified a promising therapeutic approach for the challenging blood cancer multiple myeloma.

24 Jul 2025

CoVerage outperforms rivals in early detection of COVID mutations

The CoVerage system monitors SARS-CoV-2 evolution, predicting variants and scoring amino acid changes to inform vaccine efficacy and public health strategies.

24 Jul 2025

AI identifies novel gene variants linked to Alzheimer’s risk

This study reveals how machine learning models uncover new genetic variants linked to Alzheimer’s, advancing predictive accuracy in genetic epidemiology.

24 Jul 2025

Reactivating silent genes offers hope for Rett syndrome treatment

Researchers led by UC Davis Health scientist Sanchita Bhatnagar have developed a promising gene therapy that could treat Rett syndrome.

23 Jul 2025

Blocking key host pathways may stop Cryptosporidium infections

Researchers at the Francis Crick Institute have mapped the human metabolic pathways that Cryptosporidium, an intestinal parasite, requires to survive.

23 Jul 2025

New method genetically blocks mosquitoes from transmitting malaria

Mosquitoes kill more people each year than any other animal. In 2023, the blood-sucking insects infected a reported 263 million people with malaria, leading to nearly 600,000 deaths, 80% of which were children.

23 Jul 2025

Insights into antibiotic resistance and virulence of Bordetella hinzii

Announcing a new article publication for Zoonoses journal. This study was aimed at analyzing the pathogenic characteristics of Bordetella hinzii (B. hinzii), and elucidating its antibiotic resistance mechanisms, virulence gene distribution, and vaccine development potential.

23 Jul 2025

Polygenic scores show promise for early obesity prevention

New genetic research reveals polygenic scores can predict obesity risk, offering early prevention insights while raising ethical healthcare access concerns.

23 Jul 2025

New insights reveal how FtsZ and ZapA cooperate during bacterial cell division

Bacterial cell division, a process wherein a single cell divides to form two identical daughter cells, represents one of the most essential biological processes.

22 Jul 2025

New approach doubles chemotherapy effectiveness by targeting cancer cell memory

In a wholly new approach to cancer treatment, Northwestern University biomedical engineers have doubled the effectiveness of chemotherapy in animal experiments.

22 Jul 2025

Radiation primes the immune system to attack lung tumors resistant to immunotherapy

By sparking the immune system into action, radiation therapy makes certain tumors that resist immunotherapy susceptible to the treatment, leading to positive outcomes for patients, according to new research by investigators at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Netherlands Cancer Institute.

22 Jul 2025

AI and wastewater surveillance unite to detect emerging viruses

Wastewater surveillance became a popular choice among public health officials looking to track rapid virus mutations and spread patterns during the COVID-19 pandemic.

21 Jul 2025

UC Riverside scientists develop tool to preserve mitochondrial DNA

When environmental stress harms DNA, it can set off a cascade of failures linked to heart conditions, neurodegeneration, and chronic inflammation.

21 Jul 2025

Blocking a single gene disrupts vitamin D metabolism and cancer pathways in new cell study

Researchers identified SDR42E1 as a key regulator of vitamin D absorption and sterol metabolism in colorectal cancer cells. Disruption of this enzyme altered cancer-related pathways and cell viability, highlighting its potential as a therapeutic target.

21 Jul 2025

Muscle-derived vesicles heal damaged cells and reverse disease in new study

Researchers discovered that mitochondria-rich extracellular vesicles (Ti-mitoEVs) from skeletal muscle can deliver healthy mitochondria to damaged cells, restoring energy and promoting tissue repair in mice. The approach reversed acute muscle injury and chronic kidney disease, offering a promising new regenerative therapy.

21 Jul 2025

Study identifies mechanism that helps prevent cancer, neurodegeneration, and premature aging

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the mechanism by which cells identify and repair a highly toxic form of DNA damage that causes cancer, neurodegeneration, and premature aging.

21 Jul 2025