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Study identifies factors that increase risk for breast cancer in young African American women

Black women under the age of 45 are at increased risk for an aggressive form of breast cancer [estrogen receptor (ER) negative] if they experienced a high number of pregnancies, never breast fed, and/or had higher waist-to-hip ratio.

19 Oct 2016

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Domain Therapeutics, a biopharmaceutical company that specializes in the discovery and development of G protein-coupled receptor (GPCR) drugs, today announces the creation of Mavalon Therapeutics, a company focused on stopping the progression of Parkinson’s disease.

19 Oct 2016

Folinic acid treatment could help improve language and communication skills of children with ASD

Prescription doses of folinic acid, which is a reduced form of a B vitamin known as folate, could help improve the language and communication skills of children with autism spectrum disorder (ASD).

18 Oct 2016

MIT neuroscientists identify brain cells that play vital role in controlling appetite

MIT neuroscientists have discovered that brain cells called glial cells play a critical role in controlling appetite and feeding behavior.

18 Oct 2016

NAC improves effectiveness of adoptive cell therapy for treating melanoma

A collaborative team of investigators at the Medical University of South Carolina and Loyola University have demonstrated for the first time that culturing T cells in N-acetyl cysteine (NAC) before they are infused as immunotherapy improves effectiveness and outcomes in a preclinical model of melanoma. These findings were reported in the October 15, 2016 issue of Cancer Research.

17 Oct 2016

Activation of chemical with ER-β may help reduce obesity by converting white fat to brown fat

New research, published online in The FASEB Journal, suggests that activation of a chemical called Beta-LGND2 by the estrogen receptor Beta (ER-Beta) reduces obesity and metabolic diseases in mice by converting bad fat (white fat) to good fat (brown fat).

17 Oct 2016

Long-term clinical data, experience supports effectiveness of PRRT for treating neuroendocrine tumors

More than ten years of published clinical data and personal experience using PRRT-based targeted therapy of neuroendocrine tumors supports the effectiveness of this novel treatment approach and the ability to minimize and manage potential toxic side effects.

17 Oct 2016

Scientists at NIH and Emory University induce sustained remission in SIV-infected monkeys

Scientists at the National Institutes of Health and Emory University have experimentally induced sustained remission of SIV, the simian form of HIV, in infected monkeys.

14 Oct 2016

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and prolonged survival in mouse models.

13 Oct 2016

Scientists develop smart drug that safely removes fat from liver and blood vessels

Scientists from the Technical University of Munich and Helmholtz Zentrum München have developed a ‘smart’ drug that safely clears the liver of fat and prevents blood vessels from clogging up.

13 Oct 2016

Study identifies mechanistic link between maternal obesity and childhood hypertension

Exposure of babies to high levels of the 'fullness' hormone, leptin, in the womb irreversibly activates receptors in the brain that regulate blood pressure, according to a new study by researchers from King's College London, part-funded by the British Heart Foundation.

12 Oct 2016

Research findings provide new avenues to target virus infection

Viral infection is one of the leading medical challenges of the 21st Century, ranging from the Hepatitis C Virus (HCV) epidemic affecting 3% of the global population, to recent outbreaks of West Nile, Zika, and Ebola viruses.

12 Oct 2016

Research on naked mole-rats could pave way for new human pain therapies

In injuries and inflammation, naked mole-rats do not develop normal hypersensitivity to temperature stimuli.

12 Oct 2016

Study to examine efficacy of orally administered medication in treating stuttering

Stuttering, an interruption in the flow of speech, affects about three million Americans. It begins most often in childhood, affecting four men for every woman. A precise cause of this complex communicative disorder is not known.

8 Oct 2016

Researchers describe novel host-oriented therapeutic approach for preventing lethal immune responses

Staphylococcal and streptococcal infections affect millions of individuals each year. They are a leading cause of sepsis and account for many cases of pneumonia and post-surgical infections.

8 Oct 2016

Estrogen receptor degrader increases progression-free survival in advanced breast cancer patients

Fulvestrant significantly increases progression-free survival in women with hormone-receptor-positive advanced breast cancer, particularly those with less aggressive lower-volume disease, researchers reported at the ESMO 2016 Congress in Copenhagen

8 Oct 2016

Combination treatment with CDK4/6 inhibitor improves progression-free survival in HR+ breast cancer patients

The addition of the CDK4/6 inhibitor ribociclib to letrozole therapy significantly improves progression-free survival in postmenopausal women with hormone receptor-positive advanced breast cancer, researchers reported today at the ESMO 2016 Congress in Copenhagen.

8 Oct 2016

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

The first-in-human dose escalation study of the pan-FGFR (fibroblast growth factor receptor) inhibitor BAY 1163877 in patients with treatment-refractory locally advanced or metastatic solid tumours were reported today at the ESMO 2016 Congress in Copenhagen.

8 Oct 2016

Research reveals role of endoglin in shaping blood and cardiac cell fate during early development

New research from the University of Minnesota reveals endoglin as a critical factor in determining the fate of early undifferentiated cells during development.

7 Oct 2016

Researchers explain why explain why some tumors recur after immunotherapy

Immunotherapy is a new and highly promising form of treatment for cancer. In many patients, however, tumors recur after immunotherapy.

7 Oct 2016

Receptor News and Research

Study identifies factors that increase risk for breast cancer in young African American women

Domain Therapeutics and Medicxi partner to launch Mavalon Therapeutics

Folinic acid treatment could help improve language and communication skills of children with ASD

MIT neuroscientists identify brain cells that play vital role in controlling appetite

NAC improves effectiveness of adoptive cell therapy for treating melanoma

Activation of chemical with ER-β may help reduce obesity by converting white fat to brown fat

Long-term clinical data, experience supports effectiveness of PRRT for treating neuroendocrine tumors

Scientists at NIH and Emory University induce sustained remission in SIV-infected monkeys

Depriving deadly brain cancer cells of cholesterol causes tumor regression in mouse models

Scientists develop smart drug that safely removes fat from liver and blood vessels

Study identifies mechanistic link between maternal obesity and childhood hypertension

Research findings provide new avenues to target virus infection

Research on naked mole-rats could pave way for new human pain therapies

Study to examine efficacy of orally administered medication in treating stuttering

Researchers describe novel host-oriented therapeutic approach for preventing lethal immune responses

Estrogen receptor degrader increases progression-free survival in advanced breast cancer patients

Combination treatment with CDK4/6 inhibitor improves progression-free survival in HR+ breast cancer patients

Study of pan-FGFR inhibitor uses mRNA in tumours to identify responders

Research reveals role of endoglin in shaping blood and cardiac cell fate during early development

Researchers explain why explain why some tumors recur after immunotherapy

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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