immunity News and Research

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Alzheimer's risk factors linked to cognition as early as young adulthood

A new study from Columbia University Mailman School of Public Health and the Columbia Butler Aging Center suggests that risk factors and biomarkers related to Alzheimer's disease are associated with cognition much earlier in life than previously recognized.

21 Apr 2025

Vitamin D curbs colorectal cancer by boosting immunity and blocking tumor growth

Review highlights how vitamin D, particularly its active form calcitriol, modulates immune responses, inflammation, and tumor progression to help prevent colorectal cancer (CRC). Evidence suggests adequate vitamin D levels and supplementation reduce CRC risk and improve outcomes.

21 Apr 2025

New therapeutic frontiers in the management of achondroplasia

A recent publication in Genes & Diseases has delivered a compelling synthesis of the latest insights into the cellular mechanisms and therapeutic interventions for achondroplasia, the most common form of genetic dwarfism.

20 Apr 2025

Molecular drivers and emerging treatments in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

20 Apr 2025

GOT2 as a metabolic and immunologic target in pancreatic cancer

A new wave of scientific interest is spotlighting GOT2—glutamic-oxaloacetic transaminase 2—as a compelling therapeutic target in the fight against pancreatic cancer, one of the most lethal and treatment-resistant malignancies.

20 Apr 2025

Reversing adipose tissue fibrosis through targeted microRNA therapies

A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and potentially reversing adipose tissue fibrosis, a condition closely linked to obesity, diabetes, and cardiovascular disease.

20 Apr 2025

Exploring citrullination as a key regulator of gene expression and disease

Citrullination, a transformative protein post-translational modification, is gaining recognition for its wide-ranging impact on cellular function and human disease.

20 Apr 2025

Lipid metabolism as a driver of therapy resistance in triple negative breast cancer

Lipid metabolism has emerged as a central player in the progression and therapy resistance of breast cancer, particularly the aggressive subtype known as triple-negative breast cancer (TNBC).

20 Apr 2025

Redefining cardiovascular medicine through the lens of sncRNAs

In a transformative review, small noncoding RNAs (sncRNAs) have emerged as pivotal regulators in the complex landscape of cardiovascular diseases.

20 Apr 2025

Unmasking Nrf2 as a key driver of treatment resistance in osteosarcoma

A deeper understanding of osteosarcoma, the most common primary malignant bone tumor affecting children and adolescents, is reshaping strategies for overcoming treatment resistance.

20 Apr 2025

Exploring the impact of R-loops on genome integrity and disease

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it.

19 Apr 2025

Study highlights the importance of clean water and sanitation in controlling endemic cholera

Public health strategies, from vaccination to improving sanitary conditions, may have different impacts depending on whether a disease is endemic - persisting in a particular location for an extended period of time - or a new outbreak, because the dominant transmission routes may differ, according to a new study.

18 Apr 2025

Why measles is resurging in vulnerable countries despite global progress

Global measles incidence, mortality, and DALY rates in children under five dropped significantly from 1990 to 2021. However, the COVID-19 pandemic disrupted vaccination efforts, leading to coverage declines and elevated outbreak risks in low-SDI regions.

17 Apr 2025

Calming the brain's immune cells may curb damaging inflammation in Alzheimer's

New research suggests that calming the brain's immune cells might prevent or lessen the damaging inflammation seen in Alzheimer's disease.

17 Apr 2025

Vaccine trial shows promise for saving California condors from bird flu

Researchers evaluated the safety and immune response of a poultry-derived H5N1 avian influenza vaccine in black vultures and critically endangered California condors. The findings support the use of vaccination as a conservation tool against deadly avian flu outbreaks.

17 Apr 2025

Experimental bird flu vaccine offers strong protection in preclinical trials

A vaccine under development at the University at Buffalo has demonstrated complete protection in mice against a deadly variant of the virus that causes bird flu.

17 Apr 2025

The truth about apples, supplements and immunity - What brits get wrong about their health

New research has revealed some of Brits biggest misconceptions when it comes to immune health.

17 Apr 2025

Researchers link 9 blood proteins to breast cancer and suggest 3 drugs for repurposing

Researchers used integrated Mendelian randomization in a cohort of over 247,000 individuals to identify 62 plasma proteins associated with breast cancer risk. Nine high-confidence targets, including ULK3 and CSK, showed potential for drug repurposing and immune pathway regulation.

16 Apr 2025

Gut bacteria turn bile acids into allies against cancer

Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators.

16 Apr 2025

Low vitamin D levels damage erectile health via superoxide surge, study finds

Vitamin D deficiency directly causes erectile dysfunction by increasing superoxide and reducing protective SLPI levels, as shown in human tissue and animal models. This breakthrough reveals why low vitamin D may lead to poor sexual health and resistance to standard ED treatments.

15 Apr 2025