Efficacy News and Research

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Researchers pioneer new approach to treating life-threatening snake bites

A new approach of treating life-threatening snake bites responsible for around 100,000 deaths globally each year is being pioneered by an international research consortium led by University of Bristol scientists.

5 Nov 2020

Repurposing an anxiety drug to increase the efficacy of therapies for metastatic melanoma

There are times when adding something new to the mix makes it better. Give Popeye some spinach, and you've got a fighting machine. Give Mario a mushroom, and he becomes invincible. Without drinking a potion, Alice in Wonderland would never fit through the door.

5 Nov 2020

Zinc-embedded polyamide fabrics are effective in absorbing and inactivating SARS-CoV-2

An international team of scientists has recently demonstrated that zinc-embedded polyamine fibers can effectively absorb and inactivate human respiratory viruses, including influenza A virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, a face mask or other personal protective equipment (PPE) made from this fiber is expected to provide better protection against viral transmission.

4 Nov 2020

An analysis of genetic diversity of D614G mutation in SARS-CoV-2

A new study published in the preprint server bioRxiv in November 2020 reports that the effect of the mutation is minimal, in terms of pathogenicity or altered response to neutralizing antibodies elicited against the native virus strain.

4 Nov 2020

UH professor is developing a Chinese herbal medicine formula to improve cancer therapy

University of Houston professor of pharmaceutics Ming Hu is developing and testing an ancient Chinese herbal medicine formula, first described in 280 A.D., to improve cancer therapy.

4 Nov 2020

Will an effective COVID-19 vaccine return life to normal in the US?

A new study has shown that the extent to which social distancing restrictions and face mask usage could be relaxed in the United States during the coronavirus disease 2019 (COVID-19) pandemic would greatly depend on how effective a vaccine is and the proportion of the population it covered.

4 Nov 2020

HPV vaccines found to be safe and well-tolerated in males

Human papillomavirus (HPV) is one of the most common sexually transmitted infections and cases various cancers in women and men.

4 Nov 2020

New system wirelessly captures data from pulse oximeters for COVID-19 monitoring

Automating the collection and presentation of healthcare data is crucial in the fight against COVID-19 - it adds capacity to screening efforts by automating routine tasks, thereby allowing frontline staff such as dormitory operators and healthcare workers in community care facilities to focus on more pressing tasks while receiving regular updates on the health status of the individuals under their care.

4 Nov 2020

Discoverey of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376

A team of scientists from the United States has recently revealed that small molecule inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease exhibit potent antiviral activity. These inhibitors show better efficacy when used in combination with antiviral medicine Remdesivir. The study is currently available on the bioRxiv* preprint server.

3 Nov 2020

Key populations need to be prioritized for early COVID-19 immunization in Canada

Canada's National Advisory Committee on Immunization (NACI) recommends vaccinating key populations, such as people at risk of severe illness or death, those at risk of transmitting the virus and essential workers, during the initial rollout of a COVID-19 vaccine in Canada.

3 Nov 2020

New, effective CRISPR-based gene drive approach to control transmission of malaria parasites

Employing a strategy known as "population modification," which involves using a CRISPR-Cas9 gene drive system to introduce genes preventing parasite transmission into mosquito chromosomes, University of California researchers have made a major advance in the use of genetic technologies to control the transmission of malaria parasites.

3 Nov 2020

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Oncotarget recently published "Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer" which reported that the authors investigated whether Trop-2-expression and homologous recombination repair of SN-38-mediated double-strand DNA breaks play a role in the sensitivity of triple-negative breast cancer to SG.

3 Nov 2020

Remdesivir metabolite GS-441524 inhibits SARS CoV-2 in mouse model, finds study

This new study titled, "Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model," was released online as a preprint on the bioRxiv* server, prior to undergoing the peer-review process.

2 Nov 2020

Drug combo for Type 2 diabetes continues to stay effective after two years of treatment

Patients with Type 2 diabetes often take metformin as first-line therapy to help stabilize their blood glucose.

2 Nov 2020

Novel MRI contrast agent offers hope for early detection of Alzheimer’s disease

Hong Kong Baptist University scientists have invented a novel contrast agent for magnetic resonance imaging, which enables real-time visualization and detection of the size and number of amyloid-beta in the brain, a main hallmark of Alzheimer’s disease.

2 Nov 2020

Socks coated in zinc oxide nanoparticles can prevent unpleasant foot odor

New research presented at the 29th EADV Congress, EADV Virtual, shows that socks coated in zinc oxide nanoparticles can prevent bromodosis and pitted keratolysis, reducing the negative impact this embarrassing condition has on quality of life.

2 Nov 2020

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

Now, researchers from the University of California, San Francisco, and Stanford University, California, USA, reported a safe and potent antiseptic for use in humans named ethacridine, which effectively inhibits SARS-CoV-2 even at very low concentrations of EC50 ~ 0.08 µM. Their work has is published on the preprint server bioRxiv*.

1 Nov 2020

Researchers report a novel approach to generate T-cells faster

Adoptively transferred T-cells can prolong survival and sometimes cure patients with advanced solid tumors. While promising, it can take months to generate the necessary T-cells to help these patients. Such slow speed makes this therapy impractical for most patients who need immediate treatment.

30 Oct 2020

Time machine suggests a drug testing approach for pancreatic cancer

Many patients with pancreatic cancer have only about a 10% chance of survival within five years of their diagnosis because they tend to become resistant to chemotherapy, past studies have indicated.

30 Oct 2020

Booster dose enhances immunogenicity of ChAdOx1 SARS-CoV-2 vaccine in aged mice

Now, a new study published on the pre-print server bioRxiv* shows that a single dose of the vaccine has induced cellular and humoral immunity in aged or older mice. A second dosage was needed to enhance the vaccine's immune response, showing that a prime-boost strategy may be an essential step to boost immunogenicity in the elderly.

30 Oct 2020

Efficacy News and Research

Researchers pioneer new approach to treating life-threatening snake bites

Repurposing an anxiety drug to increase the efficacy of therapies for metastatic melanoma

Zinc-embedded polyamide fabrics are effective in absorbing and inactivating SARS-CoV-2

An analysis of genetic diversity of D614G mutation in SARS-CoV-2

UH professor is developing a Chinese herbal medicine formula to improve cancer therapy

Will an effective COVID-19 vaccine return life to normal in the US?

HPV vaccines found to be safe and well-tolerated in males

New system wirelessly captures data from pulse oximeters for COVID-19 monitoring

Discoverey of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376

Key populations need to be prioritized for early COVID-19 immunization in Canada

New, effective CRISPR-based gene drive approach to control transmission of malaria parasites

Biomarkers that are predictive of clinical benefit in Trop-2-expressing triple-negative breast cancer

Remdesivir metabolite GS-441524 inhibits SARS CoV-2 in mouse model, finds study

Drug combo for Type 2 diabetes continues to stay effective after two years of treatment

Novel MRI contrast agent offers hope for early detection of Alzheimer’s disease

Socks coated in zinc oxide nanoparticles can prevent unpleasant foot odor

Ethacridine blocks SARS-CoV-2 with a distinct mode of action

Researchers report a novel approach to generate T-cells faster

Time machine suggests a drug testing approach for pancreatic cancer

Booster dose enhances immunogenicity of ChAdOx1 SARS-CoV-2 vaccine in aged mice

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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