Clinical Trial News and Research

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UNC researchers evaluate investigational medication for treatment of postpartum depression

Researchers at the University of North Carolina School of Medicine announced the publication of results from a multi-site phase 2 clinical trial with brexanolone, an investigational medication, in the treatment of severe postpartum depression.

13 Jun 2017

New treatment strategy may destroy difficult-to-treat brain tumors

A new strategy for treating brain tumors may extend or save the lives of patients diagnosed with one of the deadliest forms of cancer, according to a study from UT Southwestern Medical Center.

13 Jun 2017

Low levels of vitamin A could be strong risk factor for TB

People with low levels of vitamin A living with individuals sick with tuberculosis may be 10 times more likely to develop the disease than people with high levels of the nutrient, according to research led by investigators at Harvard Medical School.

13 Jun 2017

Review suggests need for improved treatment outcome measures in clinical trials for FXS

A group of researchers from several institutions in the USA, including Johns Hopkins Medicine, reports that its review of 22 clinical trials of fragile X syndrome (FXS) suggests the need for a wider use of newer and improved treatment outcome measurement tools for this and other several neurodevelopmental disorders.

13 Jun 2017

Clinical study shows new mechanism that BCG vaccine uses to reverse advanced type 1 diabetes

Interim results from a FDA-approved clinical trial testing the generic vaccine bacillus Calmette-Guérin (BCG) to reverse advanced type 1 diabetes are being presented at the 75th Scientific Sessions of the American Diabetes Association.

12 Jun 2017

New contact lens therapy shows potential to impact rising prevalence of myopia in children

A pioneering contact lens therapy has considerable potential to impact the rising prevalence of myopia (nearsightedness) in children, according to highly-anticipated study outcomes presented today at the British Contact Lens Association Clinical Conference in Liverpool, England.

12 Jun 2017

New trial method could be more efficient way to study stroke treatments

A sequential multiple assignment randomized trial allows researchers to test two hypotheses at once.

9 Jun 2017

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that half of the patients respond to an immunotherapy drug called pembrolizumab.

9 Jun 2017

Text messaging shows great potential to improve management of diabetes

Low-income Hispanics with Type 2 diabetes who received health-related text messages every day for six months saw improvements in their blood sugar levels that equaled those resulting from some glucose-lowering medications, researchers with the Scripps Whittier Diabetes Institute reported today.

9 Jun 2017

Removal of senescent cells could delay onset of age-related pathologies

A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies.

9 Jun 2017

Combination treatment found to effective in patients with tophaceous gout

The drug lesinurad in combination with febuxostat was better at lowering blood levels of urate than febuxostat alone in a phase III clinical trial of 324 patients with tophaceous gout.

9 Jun 2017

Novartis announces data revealing efficacy of new monoclonal antibody therapy in preventing migraine

Novartis today announced that it will present 19 scientific abstracts at the 59th Annual Scientific Meeting of the American Headache Society.

8 Jun 2017

More-is-better approach appears to improve vaccine protection from HIV-like virus in monkeys

Building on insights from an HIV vaccine regimen in humans that had partial success during a phase 3 clinical trial in Thailand, a Duke-led research team used a more-is-better approach in monkeys that appeared to improve vaccine protection from an HIV-like virus.

8 Jun 2017

Researchers find long-lasting benefits of gene therapy in dog model of myotubular myopathy

Researchers who previously showed that a gene therapy treatment could save the lives of dogs with a deadly disease called myotubular myopathy—a type of muscular dystrophy that affects the skeletal muscles—have found that the therapy is long-lasting.

7 Jun 2017

Prebiotics may be new weapon in the fight against childhood obesity

There may soon be a new tool in the fight against childhood obesity. Prebiotics reduce body fat in children who are overweight or obese by altering their gut microbiota, according to new research published in Gastroenterology, the official journal of the American Gastroenterological Association.

7 Jun 2017

Study uses prebiotic fiber to improve intestinal bacteria profile of children

A couple of teaspoons of a fiber supplement, taken daily, has produced some exciting results that will help children with overweight or obesity maintain a healthier weight and prevent many diseases caused by obesity.

7 Jun 2017

Chemotherapy drug effective at preventing breast cancer's return, gives patients a better quality of life

The chemotherapy drug capecitabine gives patients a better quality of life and is as effective at preventing breast cancer from returning as the alternative regimen called CMF, when given following epirubicin.

7 Jun 2017

Combination therapy has complete response rate in children, young adults with Hodgkin lymphoma

New research presented at the American Society of Clinical Oncology 53rd Annual Meeting in Chicago shows that a previously untested combination of a monoclonal antibody-drug conjugate with a common chemotherapy agent has a high complete-response rate in children and young adults with relapsed or refractory Hodgkin lymphoma.

6 Jun 2017

New immunotherapy sends multiple myeloma into remission

Researchers are reporting the impressive results of a new cell and gene therapy that has achieved unprecedented success in treating multiple myeloma patients. Although the study is an early one and the population only included 35 people, every one of the patients responded to the treatment and 33 (94%) were in some degree of clinical remission within two months.

6 Jun 2017

Greater gut bacteria diversity linked to longer progression-free survival in metastatic melanoma patients

The blend of bacteria in the digestive tract of metastatic melanoma patients is associated with disease progression or delay in patients treated with immunotherapy, researchers at The University of Texas MD Anderson Cancer Center report at the 2017 annual meeting of the American Society of Clinical Oncology.

6 Jun 2017

Clinical Trial News and Research

UNC researchers evaluate investigational medication for treatment of postpartum depression

New treatment strategy may destroy difficult-to-treat brain tumors

Low levels of vitamin A could be strong risk factor for TB

Review suggests need for improved treatment outcome measures in clinical trials for FXS

Clinical study shows new mechanism that BCG vaccine uses to reverse advanced type 1 diabetes

New contact lens therapy shows potential to impact rising prevalence of myopia in children

New trial method could be more efficient way to study stroke treatments

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

Text messaging shows great potential to improve management of diabetes

Removal of senescent cells could delay onset of age-related pathologies

Combination treatment found to effective in patients with tophaceous gout

Novartis announces data revealing efficacy of new monoclonal antibody therapy in preventing migraine

More-is-better approach appears to improve vaccine protection from HIV-like virus in monkeys

Researchers find long-lasting benefits of gene therapy in dog model of myotubular myopathy

Prebiotics may be new weapon in the fight against childhood obesity

Study uses prebiotic fiber to improve intestinal bacteria profile of children

Chemotherapy drug effective at preventing breast cancer's return, gives patients a better quality of life

Combination therapy has complete response rate in children, young adults with Hodgkin lymphoma

New immunotherapy sends multiple myeloma into remission

Greater gut bacteria diversity linked to longer progression-free survival in metastatic melanoma patients

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