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Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Researchers found that KLF15 is crucial for maintaining white adipocyte properties in subcutaneous fat, and its deletion induces beige adipocyte characteristics, suggesting new obesity treatment pathways.

4 Jul 2024

Protein nanocages: A promising frontier in mRNA therapeutics

In recent years, messenger RNA (mRNA) has emerged as a promising avenue for accurate and potent therapeutic interventions. Unlike DNA drugs, mRNA can express genetic information without the risk of integrating into the host genome.

3 Jul 2024

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

Neuroendocrine tumors, including small cell lung cancer and neuroendocrine prostate cancer, are very aggressive with high chances of spreading.

2 Jul 2024

From Africa to Eurasia: Genetic insights into human migration and cold adaptation

"Who are we and where do we come from?" This quintessential question has intrigued humanity for millennia.

2 Jul 2024

Study provides new clues in the understanding of how antibiotic resistance spreads

A study at Umeå University, Sweden, provides new clues in the understanding of how antibiotic resistance spreads.

1 Jul 2024

Pristimerin induces apoptosis in non-small cell lung cancer by targeting thioredoxin reductase

Announcing a new publication for Acta Materia Medica journal. Elevated cellular oxidative stress is a common marker of cancer cell dysregulation caused by malignant transformation.

30 Jun 2024

Dietary fiber intake reshapes tryptophan metabolism, promoting gut health and reducing disease risks

A recent study in Nature Microbiology reveals that increased dietary fiber intake directs microbial tryptophan metabolism, leading to health benefits such as improved gut mucosa integrity and reduced risk of metabolic disorders.

27 Jun 2024

Study identifies key neurons controlling threat response and escape in mice

Neuroscientists have discovered how the brain bidirectionally controls sensitivity to threats to initiate and complete escape behaviour in mice. These findings could help unlock new directions for discovering therapies for anxiety and post-traumatic stress disorder (PTSD).

27 Jun 2024

Adaptive therapy approach can reduce toxicity and drug resistance in ovarian cancer

Ovarian cancer, often diagnosed at an advanced stage, presents significant treatment challenges because patients tend to develop resistance to conventional therapies quickly.

26 Jun 2024

“G900” gene enhancers may play a pivotal role in asthma-associated inflammation

Type-2 helper T (Th2) cells play intricate roles in the inflammatory response underlying asthma. Elevated levels of the protein GATA3 stimulate the maturation of these cells. Consequently, gene regions known as enhancers, which enhance the expression of the GATA3 gene, have been implicated in asthma-associated inflammation.

26 Jun 2024

Designing hybrid antibodies with enhanced mobility and signaling capacity

Antibodies are the body's superheroes, recognizing and eliminating disease-causing substances.

25 Jun 2024

Senecavirus A could be a promising new therapeutic approach for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly aggressive tumor with limited treatment options and high mortality.

25 Jun 2024

Sapio Sciences Introduces Sapio GMP LIMS Offering Unmatched Flexibility for Unique Manufacturing Processes

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From Sapio Sciences 25 Jun 2024

Chimpanzees seek out tree bark and ferns with medicinal benefits, researchers discover

Researchers investigated the behavioral and pharmacological effects of self-medicative plants in the diets of Budongo chimpanzees.

25 Jun 2024

Study links gene regulation to allergic airway inflammation

Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by Type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s). Both Th2 and ILC2 require high amounts of GATA-binding protein 3 (GATA3) for their maturation.

25 Jun 2024

Using microbial community-scale metabolic modeling approach for precision nutrition

Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more.

24 Jun 2024

New study warns of potential pandemic risk from α-H1N2 swine flu virus

The α-H1N2 influenza virus in swine poses a higher pandemic risk due to its ability to evade human immunity and transmit between species, highlighting the need for vigilant monitoring.

23 Jun 2024

Novo Nordisk presents key findings from semaglutide trials at ADA scientific sessions 2024

Novo Nordisk today announced the presentation of 34 abstracts highlighting the breadth of its portfolio at the upcoming 84th Scientific Sessions of the American Diabetes Association (ADA).

22 Jun 2024

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring 'youthful' levels of a specific subunit of the telomerase enzyme can significantly reduce the signs and symptoms of aging in preclinical models.

21 Jun 2024

Study reveals cognitive benefits of ketogenic diet in aged mice

The impact of cyclic ketogenic diet treatments in improving the age-related decline in brain function.

20 Jun 2024

in vivo News and Research

Scientists unveil KLF15 transcription factor's role in white fat cells, opening new paths for obesity therapy

Protein nanocages: A promising frontier in mRNA therapeutics

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

From Africa to Eurasia: Genetic insights into human migration and cold adaptation

Study provides new clues in the understanding of how antibiotic resistance spreads

Pristimerin induces apoptosis in non-small cell lung cancer by targeting thioredoxin reductase

Dietary fiber intake reshapes tryptophan metabolism, promoting gut health and reducing disease risks

Study identifies key neurons controlling threat response and escape in mice

Adaptive therapy approach can reduce toxicity and drug resistance in ovarian cancer

“G900” gene enhancers may play a pivotal role in asthma-associated inflammation

Designing hybrid antibodies with enhanced mobility and signaling capacity

Senecavirus A could be a promising new therapeutic approach for hepatocellular carcinoma

Sapio Sciences Introduces Sapio GMP LIMS Offering Unmatched Flexibility for Unique Manufacturing Processes

Chimpanzees seek out tree bark and ferns with medicinal benefits, researchers discover

Study links gene regulation to allergic airway inflammation

Using microbial community-scale metabolic modeling approach for precision nutrition

New study warns of potential pandemic risk from α-H1N2 swine flu virus

Novo Nordisk presents key findings from semaglutide trials at ADA scientific sessions 2024

Restoring youthful TERT levels reverses aging phenotypes in preclinical models

Study reveals cognitive benefits of ketogenic diet in aged mice

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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